Co-renitek treatment of patients withmoderate and severe forms of hypertensive disease

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Abstract

Aim. To evaluate efficacy and tolerance of a compound drug co-renitec combining an ACE inhibitor
enalapril maleate and diuretic hydrochlorothiazide co-renitec taken for 16 weeks in essential hypertension (EH).

Material and methods. 28 patients with EH (16 males and 12 females aged 47-74 years) of mean
duration 13.1+1.6 years. Blood pressure (Bp) was monitored for 24 hours with the device SL 90207
(SpaceLabs Medical, USA). Microalbuminuria (MAD) was estimated with the use of immunoturbodimetric test.

Results. By 24-hour monitoring, co-renitec reduced day BP by 14.9/8.9 ± 3/2 mm Hg, nocturnal BP
lowered by 18.6/11.4 ± 3/2 mmHg, pulse pressure also fell. Coefficient T/P was 53.5% for systolic BP
(SBP) and 59.6% for diastolic BP (DBP). The target SBP was reached in 77% patients, target DBP -in 69%.
Co-renitec significantly decreased MAU, albumines excretion normalized in 46% patients.
Conclusion. Co-renitec lowers both day and nocturnal blood pressure, improves 24-h rhythm of BP,
has a positive effect on the kidneys. This allows its recommendation as a first-line drug in patients with
moderate and severe EH.

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