Superhigh doses of dexamethasone in the treatment of refractory forms of acute lymphoblast leukemia of adults

Abstract


Aim. Assessment of high-dose dexamethasone efficacy in combination with standard drugs (adriablatin,
vincristin, a-asparaginase) in patients with refractory acute lymphoblastic leukemia (ALE).
Material and methods. A pilot multicenter trial with participation of hematological departments of Hematological
Research Center (Moscow), municipal hospital N 1 (Krasnoyarsk), municipal hospital N\8
(Yaroslavl), Research Institute of Hematology and Blood Transfusion (Kirov) included 34 patients (jtQ
patients with late recurrences, 24 - with primary resistant forms, early and secondary recurrences)
Results. In patients with late ALL recurrences a complete remission (CR) was achieved in 70% cases,
the median being 10 months. In patients with primary resistant ALL, early and secondary recurrences
CR reached 37.5%, the median was 14 months.
Conclusion. The program HiDexa is highly effective : overall complete remission rate reached 47%,
median of complete remission duration was 10 months. Dexamethasone in high doses must be used only
intravenously.

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Copyright (c) 2020 Parovichnikova E.N., Savchenko V.G., Isaev V.G., Sokolov A.N., Moskov V.I., Klyasova G.A., Galtseva I.V., Ustinova E.N., Gribanova E.O., Lapin V.A., Zagoskina T.P.

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