The 2015 Federal Clinical Guidelines for Antimicrobial Therapy and Prevention of Infections of the Kidney, Urinary Tract, and Male Genitals


This paper reviews the latest federal guidelines published in 2015. Emphasis is placed on the etiology and pathogenesis of uncomplicated lower urinary tract infection (uLUTI). There are data of the last Russian Darmis-2011 study of urinary tract infection pathogens and their resistance to essential antibiotics. The paper reveals the causes of persistence of uropathogenic Escherichia coli, the main pathogen of uLUTI, and shows the occurrence of intracellular bacterial communities in the superficial layer of the bladder mucosa, which are characteristic of recurrent cystitis. There are justified treatment and prevention regimens using both first-line and alternative drugs for uLUTI and recurrent iLUTI.

About the authors

T S Perepanova


  1. Российские национальные рекомендации «Антимикробная терапия и профилактика инфекций почек, мочевыводящих путей и мужских половых органов». М.; 2012.
  2. Grabe M (Chair), Bartoletti R, Johansen BTE, Çek M, Köves B, Naber KG, Pickard RS, Tenke P, Wagenlehner F, Wullt B. Guidelines on Urological Infections. European Association of Urology; 2015.
  3. Сепсис в начале XXI века. Классификация, клинико-диагностическая концепция и лечение. Патологоанатомическая диагностика: Практическое руководство. Москва: Издательство НЦССХ им. А.Н. Бакулева РАМН; 2004.
  4. U.S. Department of Health and Human Services Public Health Service Agency for Health Care Policy and Research; 1992.
  5. Urogenital infections. Ed. Kurt Naber, Anthony J. Schaeffer, Chris F. Heyns, Tetsuro Matsumoto, Daniel A. Shoskes, T.E. Bjerklund Johansen. Unternational Consultation on Urogenital Infections, Stockholm, Sweden, March 2009; Ed. 2010, EAU.
  6. Kunin CM. Urinary Tract Infections: Detection, Prevention and Management. 5th ed. Williams & Wilkins; 1997.
  7. Escherichia coli. Virulence Mechanisms of a Versatile Pathogen. Ed. by MS Donnenberg. USA: Elsevier Science; 2002.
  8. Roche N, Bergsten G et al. Colonization of mucosal surfaces. ASM press; 2005
  9. Lutay N, Ambite I, Gronberg Hernandez J, Rydstrom G, Ragnarsdottir B, Puthia M et al. Bacterial control of host gene expression through RNA polymerase II. J Clin Investigat. 2013;123(6):2366-2379.
  10. Палагин И.С., Сухорукова М.В., Дехнич А.В., Эйдельштейн М.В., Шевелев А.Н., Гринев А.В., Перепанова Т.С., Козлов Р.С., исследовательская группа «ДАРМИС». Современное состояние антибиотикорезистентности возбудителей внебольничных инфекций мочевых путей в России: результаты исследования «ДАРМИС» (2010—2011). Клиническая микробиология и антимикробная химиотерапия. 2012;14(4):280-302.
  11. Страчунский Л.С., Белоусов Ю.Б., Козлов С.Н. Антибактериальная терапия. Практическое руководство под ред. Л.С. Страчунского, Ю.Б. Белоусова, С.Н. Козлова Москва; 2000
  12. Bacterial pathogenesis: a molecular approach. Wilson BA, Salyers AA, Whitt DiD, Malcolm E. Winkler-3rd ed. 6. USA: ASM press; 2011.
  13. Рациональная фармакотерапия в урологии: Руководство для практикующих врачей. Под ред. Лопаткина Н.А., Перепановой Т.С.. М.: Литтерра; 2012.
  14. Dellit TH, Owens RC, McGowan JE Jr, Gerding DN, Weinstein RA, Burke JP, Huskins WC, Paterson DL, Fishman NO, Carpenter CF, Brennan PJ, Billeter M, Hooton TM. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America Guidelines for Developing an Institutional Program to Enhance Antimicrobial Stewardship. Antimicrobial Stewardship Guidelines CID 2007:44 (15 January) 159.



Abstract: 99

PDF (Russian): 628

Article Metrics

Metrics Loading ...


  • There are currently no refbacks.

Copyright (c) 2020 Perepanova T.S.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Address of the Editorial Office:

  • Novij Zykovskij proezd, 3, 40, Moscow, 125167

Correspondence address:

  • Novoslobodskaya str 31c4., Moscow, 127005, Russian Federation

Managing Editor:


© 2018-2021 "Consilium Medicum" Publishing house

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies