Email this article Gastric and duodenal secretory and motor-evacuatory activity in patients with gastroesophageal reflux disease associated with different types of reflux
- Authors: Dzhulay GS1, Sekareva EV1
-
Affiliations:
- Issue: Vol 88, No 2 (2016)
- Pages: 16-20
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/31906
- ID: 31906
Cite item
Full Text
Abstract
Aim. To estimate esophageal and gastric pH values on an empty stomach and after stimulation of gastric secretion and gastric and duodenal motor-evacuatory activity in patients with gastroesophageal reflux disease (GERD) associated with pathological refluxes, such as gastroesophageal reflux (GER) and duodenogastroesophageal reflux (DGER). Subjects and methods. The observational cross-sectional study was conducted to investigate and compare the parameters of intraesophageal and intragastric pH metry and peripheral electrogastroenterography in 103 GERD patients with endoscopically positive distal reflux esophagitis in GER and DGER. Results. The patients with GERD developed pathological esophageal refluxes (both GER and DGER) in various degrees of impaired gastric production, from anacidity to hyperacidity. The patients with predominant DGER were found to have gastric hyperacidity and normal acidity slightly less frequently than those with predominant GER. The patients with GERD developing in the presence of predominant GER had moderate gastric stasis with discoordinated antroduodenal propulsion resulting from hypomotor dyskinesia of the stomach and duodenum. When DGER was predominant in the patients with GERD, the signs of gastric stasis and duodenal hyperkinesia were concurrent with discoordinated antroduodenal and duodenojejunal propulsion. Conclusion. The specific features of the esophagogastroduodenal secretory and motor evacuatory disorders found create conditions for the pathological refluxes into the esophagus, which differ in the composition of refluxate.
References
- Dent J. From 1906 to 2006 — a сentury of major evolution of understanding of gastro-oesophageal refluxe disease: review article. Aliment Pharmacol Ther. 2006;24(9):1269-1281.
- Лазебник Л.Б. Изжога и гастроэзофагеальная рефлюксная болезнь: проблемы и решения. Терапевтический архив. 2008;2:5-11.
- Savarino E, Gemignani L, Pohl D, Zentilin P, Dulbecco P, Assandri L, Marabotto E, Savarino V. Oesophageal motility and bolus transit abnormalities in parallel with severity of gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2011;34(4):476-486.
- Van Rensburg K. Gastro-oesophageal reflux disease (GORD). SAPharmaceutical J. 2010;77(10):34-37.
- Dominigues GR, Winograd R, Lemme EM, Lammert F, Silny J, Matern S, Nguyen HN. Characteristics of oesophageal bolus transport in patients with mild oesophagitis. Eur J Gastroenterol Hepatol. 2005;17(3):323-332.
- Becher A, Dent J. Systematic review: Ageing and gastro-oesophageal reflux disease symptoms, oesophageal function and reflux oesophagitis. Aliment Pharmacol Ther. 2011;33(4):442-454.
- Penagini R, Bravi I. The role of delayed gastric emptying and impaired oesophageal body motility. Best Practice and Research: Clin Gastroenterol. 2010;24(6):831-845.
- Brilliantino A, Monaco L, Schettino M, Torelli F, Izzo G, Cosenza A, Marano L, Di Martino N. Prevalence of pathological duodenogastric and duodenogastrooesophageal reflux in chronic gastrooesophageal reflux disease. Eur J Gastroenterol Hepatol. 2008; 20(12):1136-1143.
- Ивашкин В.Т., Трухманов А.С. Холинергическая регуляция: ее роль в осуществлении двигательной функции пищевода и клиренса при гастроэзофагеальной рефлюксной болезни. Клинические перспективы гастроэнтерологии, гепатологии. 2011;4:3-8.
- Джулай Г.С., Секарева Е.В., Курицын В.М., Джулай Т.Е. Клинико-патогенетические варианты гастроэзофагеальной рефлюксной болезни: факторы риска и предикторы развития. Терапевтический архив. 2013;85(2):8-12.
- Оседло Г.В., Радушинская М.В. Роль вегетативной дисфункции и ее коррекции при гастроэзофагеальной рефлюксной болезни. Гастроентерологiя. 2014;2(52):13-16.
- Погромов А.П., Дрокова Г.М., Рыкова С.М., Вейн А.М. Психовегетативные аспекты у больных гастроэзофагеальной рефлюксной болезнью и функциональными расстройствами желудка. Клиническая медицина. 2005;83(12):41-44.
Supplementary files
