IgG4-related disease and clonal B-cell lymphoid proliferation: Description of two clinical cases and a review of literature


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Abstract

IgG4-related disease (IgG4-RD) is a systemic immune-related disease that may involve the pancreas, liver, retroperitoneal space, biliary tract, salivary and lacrimal glands, eye socket, lung, and kidney. In term of pathomorphogenesis, it is a fibroinflammatory disease manifesting as a tumor-like lesion of organs, elevated serum IgG4 levels, and a morphofunctional substrate – the development of marked fibrosis and lymphoplasmacytic infiltration in the tissues with the high content of IgG4-positive plasma cells. The detection of a tumor-like nodule frequently leads to that the patients with IgG4-RD undergo major traumatic surgery for presumed cancer. At the same time, a number of investigations show the association of IgG4-RD with the development of cancer and lymphoproliferative diseases. The paper describes two clinical cases: Russia’s first diagnosis of MALT lymphoma of the lacrimal gland, IgG4-positive and IgG4-RD with a rare onset with a destruction focus in the cervical vertebrae, multiple organ dysfunction, B-cell clonality in salivary gland tissue and PIgMκ secretion. It also reviews world literature on the development of lymphoproliferative diseases in the presence of IgG4-RD.

References

  1. Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Yoshino T, Nakamura S, Kawa S, Hamano H, Kamisawa T, Shimosegawa T, Shimatsu A, Nakamura S, Ito T, Notohara K, Sumida T, Tanaka Y, Mimori T, Chiba T, Mishima M, Hibi T, Tsubouchi H, Inui K, Ohara H. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod Rheumatol. 2012;22(1):21-30. doi: 10.1007/s10165-011-0571-z.
  2. Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, Klöppel G, Heathcote JG, Khosroshahi A, Ferry JA, Aalberse RC, Bloch DB, Brugge WR, Bateman AC, Carruthers MN, Chari ST, Cheuk W, Cornell LD, Fernandez-Del Castillo C, Forcione DG, Hamilos DL, Kamisawa T, Kasashima S, Kawa S, Kawano M, Lauwers GY, Masaki Y, Nakanuma Y, Notohara K, Okazaki K, Ryu JK, Saeki T, Sahani DV, Smyrk TC, Stone JR, Takahira M, Webster GJ, Yamamoto M, Zamboni G, Umehara H, Stone JH. Consensus statement on the pathology of IgG4-related disease. Modern Pathol. 2012;25(9):1181-1192. doi: 10.1038/modpathol.2012.72.
  3. Yamamoto M, Takahashi H, Tabeya T et al. Risk of malignancies in IgG4-related disease. Mod Rheumatol. 2012;22(3):414-418.
  4. Kermani TA, Crowson CS, Achenbach SJ et al. Idiopathic retroperitoneal fibrosis: a retrospective review of clinical presentation, treatment, and outcomes. Mayo Clin Proc. 2011;86(4):297-303.
  5. Smedby KE, Baecklund E, Askling J. Malignant lymphomas in autoimmunity and inflammation: a review of risks, risk factors, and lymphoma characteristics. Cancer Epidemiol Biomarkers Prev. 2006;15:2069-2077.
  6. Baecklund E, Smedby KE, Sutton LA et al. Lymphoma development in patients with autoimmune and inflammatory disorders — what are the driving forces? Semin Cancer Biol. 2014;24:61-70.
  7. Smedby KE, Vajdic CM, Falster M, Engels EA, Martínez-Maza O, Turner J, Hjalgrim H, Vineis P, Seniori Costantini A, Bracci PM, Holly EA, Willett E, Spinelli JJ, La Vecchia C, Zheng T, Becker N, De Sanjosé S, Chiu BC, Dal Maso L, Cocco P, Maynadié M, Foretova L, Staines A, Brennan P, Davis S, Severson R, Cerhan JR, Breen EC, Birmann B, Grulich AE, Cozen W. Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium. Blood. 2008;111(8):4029-4038. doi: 10.1182/blood-2007-10-119974.
  8. Vaillo A, Gutierrer-Martin A, Ballestin C. Marginal zone B cell lymphoma of the parotid gland associated with epitelioid granulomas. Report of a case with fine needle aspiration. Acta Cytol. 2004;48(3):420-424.
  9. Сидорова Ю.В., Рыжикова Н.В., Смирнова С.Б. и др. Определение В-клеточной клональности при лимфоме Ходжкина. Клиническая онкогематология. 2014;7(1):63-66.
  10. Мационис А.Э., Повилайтите П.Е., Петров А.В. Молекулярно-генетическое исследование клональности В- и Т-лимфо­цитов в диагностике неходжкинских лимфом. Архив патологии. 2012;4:57-62.
  11. Langerak AW, Groenen PJ, van Krieken JH et al. Immunoglobulin/T-cell receptor clonality diagnostics. Expert Opin Med Diagn. 2007;1(4):451-461.
  12. Svachova M, Tichy M. PCR analysis of immunoglobulin heavy chain and TCR gene rearrangements in diagnosis of lymphoproliferative disorders on formalin-fixed, paraffin-embedded tissues. Neoplasma. 2008;55(1):36-41.
  13. Ochoa ER, Harris NL, Pilch BZ. Marginal zone B-cell lymphoma of the salivary gland arising in chronic sclerosing sialadenitis (Küttner tumor). Am J Surg Pathol. 2001;25:1546-1550.
  14. Cheuk W, Yuen HK, Chan AC et al. Ocular adnexal lymphoma associated with IgG4+ chronic sclerosing dacryoadenitis: a previously undescribed complication of IgG4-related sclerosing disease. Am J Surg Pathol. 2008;32:1159-1167.
  15. Oyama T, Takizawa J, Nakamura N et al. Multifocal mucosa-associated lymphoid tissue lymphoma associated with IgG4-related disease: a case report. Jpn J Ophthalmol. 2011;55(3):304-306. doi: 10.1007/s10384-011-0003-9.
  16. Naresh KN, Barwick T, Karadimitris A. IgG4 positive mucosa associated lymphoid tissue lymphomas of the orbit — lesson of the month. Histopathology. 2014;65(5):718-721.
  17. Ferry JA, ed. Extranodal lymphomas. Elsevier Saunders; 2011.
  18. Kim T, Grobmyer SR, Dixon LR et al. Autoimmune pancreatitis and concurrent small lymphocytic lymphoma: not just a coincidence? J Gastrointest Surg. 2008;12:1566-1170. http://dx.doi.org/10.1007/s11605-008-0543-6.
  19. Takahashi N, Ghazale AH, Smyrk NC et al. Possible association between IgG4-associated systemic disease with or without autoimmune pancreatitis and non-Hodgkin lymphoma. Pancreas. 2009;38:523-526. http://dx.doi.org/10.1097/mpa.0b013e31819d73ca
  20. Kermani TA, Crowson CS, Achenbach SJ et al. Idiopathic retroperitoneal fibrosis: a retrospective review of clinical presentation, treatment, and outcomes. Mayo Clin Proc. 2011;86(4):297-303.
  21. Lightfoot N, Kalnins R. Diffuse large B-cell lymphoma/follicular lymphoma arising in a background of IgG4-related pachymeningitis. Pathology. 2013;45(7):696-698.
  22. Kanda G, Ryu T, Shirai N et al. Peripheral T-cell lymphoma that developed during the follow-up of IgG4-related disease. Intern Med. 2011;50:155-160.
  23. Cheuk W, Tam FK, Chan AN et al. Idiopathic cervical fibrosis — a new member of IgG4-relsted sclerosing disease: report of 4 cases, 1 complicated by composite lymphoma. Am J Pathol. 2010;34:1678-1685. http://dx.doi.org/10/1097/pas.0b013e3181f12c85
  24. Hamano H, Kawa S, Horiuchi A et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med. 2001;344:732-738.
  25. Sato Y, Oshima K, Ichimura K et al. Ocular adnexal IgG4-related disease has uniform clinicopathology. Pathol Int. 2008;58:465-470.
  26. <http://dx.doi.org/10.1111/j.1440-1827.2008.02257.x. PIN2257> [pii].
  27. Ferry J, Deshpande V. IgG4-related disease in head and neck. Seminars in Diagnostic Pathology. 2012;29:235-244.
  28. Matsuo T, Ichimura K, Yoshiko T et al. Local recurrence as immunoglobulin G4 (IgG4)-related disease 10 years after radiotherapy to ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. J Clin Exp Hematol. 2011;51:125-133. JST.JSTAGE/jslrt/51.125 [pii]
  29. Yamamoto M, Takahashi H, Tabeya T et al. Risk of malignancies in IgG4-related diseases. Mod Rheumatol. 2012;22(3):414-418.
  30. Ferry J. IgG4-related lymphadenopathy and IgG4-related lymphoma: moving tergets. Diagnostic Histopathology. 2013;19(4):128-139. doi: 10.1016/j.mpdhp.2013.01.005.
  31. Venkataraman G, Rizzo KA, Chavez JJ et al. Marginal zone lymphomas involving meningeal dura: possible link to IgG4-related diseases. Mod Pathol. 2011;24:355-366.
  32. Sato Y, Takata K, Ichimura K et al. IgG4-producing marginal zone B-cell lymphoma. Int J Hematol. 2008;88:428-433.
  33. Ferry J, Fung CY, Zukerberg L et al. Lymphoma of the ocular adnexa: a study of 353 cases. Am J Surg Pathol. 2007;31:170-184.

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