Successful treatment for cryptococcal meningoencephalitis complicated by cerebral salt-wasting syndrome in a patient with chronic lymphocytic leukemia: A clinical case


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Abstract

Cryptococcus neoformans is a common agent of fungal meningoencephalitis in immunocompromised patients. Cerebral salt-wasting syndrome is one of the rare causes of severe hyponatremia in patients with CNS diseases. The paper describes the first clinical case of a patient, whose onset of chronic lymphocytic leukemia was complicated by cryptococcal meningoencephalitis presenting with mental disorders and severe electrolytic imbalance. Antifungal treatment with amphotericin B and fluconazole could alleviate an infectious process and metabolic disturbances.

References

  1. Климко Н.Н. Микозы: диагностика и лечение. 2-е изд. перераб и доп. М.: Ви Джи Групп; 2008.
  2. Liu TB, Perlin DS, Xue C. Molecular mechanisms of cryptococcal meningitis. Virulence. 2012;3(2):173-181.
  3. Perfect JR, Dismukes WE, Dromer F. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of America. Clin Infect Dis. 2010;50(3):291-322.
  4. Ramos-e-Silva M, Lima CM, Schechtman RC, Trope BM, Carneiro S. Systemic mycoses in immunodepressed patients (AIDS). Clin Dermatol. 2012;30(6):616-627.
  5. Laniado-Laborín R, Cabrales-Vargas MN. Amphotericin B: side effects and toxicity. Rev Iberoam Micol. 2009;26(4):223-227.
  6. Albanese A, Hindmarsh P, Stanhope R. Management of hyponatraemia in patients with acute cerebral insults. Arch Dis Child. 2001;85(3):246-251.
  7. Swerdlow SH, Campo E, Harris NL. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue. IARC: Lyon; 2008.
  8. Ходунова Е.Е., Фролова И.Н., Паровичникова Е.Н. Криптококкоз в гематологической практике. Терапевтический архив. 2013;11:41-46.
  9. Momi J, Tang C, Abcar AC, Kujubu DA, Sim JJ. Hyponatremia in a patient with cryptococcal meningitis: syndrome of inappropriate antidiuretic hormone (SIADH) or cerebral salt wasting (CSW)? J Hosp Med. 2010;5(3):193-195.
  10. Harrigan MR. Cerebral salt wast ing syndrome: a review. Neurosurgery. 1996;38(1):152-160.
  11. Izumi Y, Sakaguchi K, Udaka F, Tsujimura T, Kameyama M. A patient with meningeal carcinomatosis accompanied by a small pituitary metastatic lesion from gastric cancer who developed cerebral salt wasting syndrome. Nihon Ronen Igakkai Zasshi. 1999;36(9):657-662.
  12. Khostelidi SN, Sorokina MM, BorzovaYV. Cryptococcosis of lungs in patients without HIV-infection. Case report and review of literature. Problems in medical mycology. 2013;15(2):18-24.
  13. Haddow LJ, Colebunders R, Meintjes G. Cryptococcal immune reconstitution inflammatory syndrome in HIV-1-infected individuals: proposed clinical case definitions. Lancet Infect Dis. 2010;10(11):791-802.

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