Increased serum concentrations of inflammatory cytokines in type 2 diabetic patients with chronic kidney disease


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Abstract

Aim. To study the relationship between serum inflammatory cytokine levels in chronic kidney disease patients with type 2 diabetes. Subjects and methods. Sixty-four patients aged 43 to 70 years with a glomerular filtration rate (GFR) of >30 ml/min/1.73 m2 were examined. A control group consisted of 15 healthy individuals. The serum concentration of macrophage colony-stimulating factor (M-CSF), macrophage inflammatory protein 1α (MIP-1α), macrophage migration inhibitory factor (MIF), interleukin 6 (IL-6), as well as the urinary excretion of albumin and type IV collagen was determined by enzyme immunoassay. Results. In patients with a GFR of >60 ml/min/1.73 m2, M-CSF and MIF concentrations proved to be significantly higher than those in the control group (p=0.0003 and p=0.001, respectively). In those with a GFR of 30-59 ml/min/1.73 m2, there was an increase in the levels of M-CSF (p<0.0001), MIP-1α (p=0.002), MIF (p=0.02), and IL-6 (p=0.02). The decline in GFR was associated with the higher levels of M-CSF (p=0.02) and MIP-1α (p=0.02) and with the higher urinary excretion of type IV collagen (p=0.01). M-CSF, MIP-1α, and IL-6 correlated positively with the urinary excretion of albumin (r=0.34, r=0.28, and r=0.28, respectively; all p<0.05) and type IV collagen (r=0.31, r=0.4, and r=0.43, respectively; all p<0.05). Conclusion. The findings confirm the concept that chronic inflammation is involved in the development of diabetic kidney disease.

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