Significance of surfactant proteins in the diagnosis of therapeutic diseases


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Abstract

The lung provides not only respiration, but also the functioning of innate immunity mechanisms. The hydrophilic proteins SP-A and SP-D are responsible for the regulation of the latter. In the literature, there is evidence for elevated serum SP-A and SP-D levels in respiratory diseases accompanied by enhanced mucosal inflammation of the lung or its parenchymal injury and their association with age and cardiovascular diseases has been recently found. Studies of the efficiency of using SP-A and SP-D as specific markers for inflammatory lung diseases are presently worthwhile.

References

  1. Микеров А.Н. Роль сурфактантного белка А в иммунной защите легких. Фунд исследования 2012; 2: 204-207.
  2. Chroneos Z.C., Sever-Chroneos Z., Shepherd V.L. Pulmonary surfactant: an immunological perspective. Cell Physiol Biochem 2010; 25: 13-26.
  3. Wu H., Kuzmenko A., Wan S. et al. Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability. J Clin Invest 2003; 111: 1589-1602.
  4. Brinker K.G., Garner H., Wright J.R. Surfactant protein A modulates the differentiation of murine bone marrow-derived dendritic cells. Am J Physiol Lung Cell Mol Physiol 2003; 284: L232-241.
  5. Wright J.R., Youmans D.C. Pulmonary surfactant protein A stimulates chemotaxis of alveolar macrophage. Am J Physiol Lung Cell Mol Physiol 1993; 264: L338-344.
  6. Borron P., McIntosh J.C., Korfhagen T.R. et al. Surfactant-associated protein A inhibits LPS-induced cytokine and nitric oxide production in vivo. Am J Physiol Lung Cell Mol Physiol 2000; 278: L840-847.
  7. Kremlev S.G., Phelps D.S. Surfactant protein A stimulation of inflammatory cytokine and immunoglobulin production. Am J Physiol Lung Cell Mol Physiol 1994; 267: L712-719.
  8. Van Iwaarden F., Welmers B., Verhoef J. et al. Pulmonary surfactant protein а enhances the host-defense mechanism of rat alveolar macrophages. Am J Respir Сell Mol Biol 1990; 2: 91-98.
  9. Hickman-Davis J.M., Gibbs-Erwin J., Lindsey J.R., Matalon S. Role of surfactant protein-A in nitric oxide production and mycoplasma killing in congenic C57BL/6 mice. Am J Respir Сell Mol Biol 2004; 30: 319-325.
  10. Schagat T.L., Wofford J.A., Wright J.R. Surfactant protein A enhances alveolar macrophage phagocytosis of apoptotic neutrophils. J Immunol 2001; 166: 2727-2733.
  11. Hickman-Davis J.M., O'Reilly P., Davis I.C. et al. Killing of Klebsiella pneumoniae by human alveolar macrophages. Am J Physiol Lung Cell Mol Physiol 2002; 282: L944-956.
  12. Mikerov A.N., Umstead T.M., Huang W. et al. SP-A1 and SP-A2 variants differentially enhance association of Pseudomonas aeruginosa with rat alveolar macrophages. Am J Physiol Lung Cell Mol Physiol 2005; 288: L150-158.
  13. Voss T., Melchers K., Scheirle G., Schafer K.P. Structural comparison of recombinant pulmonary surfactant protein SP-A derived from two human coding sequences: implications for the chain composition of natural human SP-A. Am J Respir Сell Mol Biol 1991; 4: 88-94.
  14. Mikerov A.N., Wang G., Umstead T.M. et al. Surfactant protein A2 (SP-A2) variants expressed in CHO cells stimulate phagocytosis of Pseudomonas aeruginosa more than Do SP-A1 variants. Infect Immun 2007; 75: 1403-1412.
  15. Wang G., Bates-Kenney S.R., Tao J.Q. et al. Differences in biochemical properties and in biological function between human SP-A1 and SP-A2 variants, and the impact of ozone-induced oxidation. Biochemistry 2004; 43: 4227-4239.
  16. Wang G., Phelps D.S., Umstead T.M., Floros J. Human SP-A protein variants derived from one or both genes stimulate TNF-alpha production in the THP-1 cell line. Am J Physiol Lung Cell Mol Physiol 2000; 278: L946-954.
  17. Gardai S.J., Xiao Y.-Q., Dickinson M. et al. By binding SIRP-alpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell 2003; 115:13-23.
  18. Phelps D.S. Surfactant regulation of host defense function in the lung: a question of balance. Pediatr Pathol Mol Med 2001; 20: 269-292.
  19. Guo C.J., Atochina-Vasserman E.N., Abramova H. et al. S-Nitrosylation of surfactant protein-D controls inflammatory function. PLoS Biology, 2004; 6 (11): 266.
  20. Atochina E.N., Beck J.M., Scanlon S.T. et al. Pneumocystis carinii pneumonia alters expression and distribution of lung collectins SP-A and SP-D. J Lab Clin Med 2001; 137: 429-439.
  21. Atochina E.N., Beers M.F., Hawgood S. et al. Surfactant protein-D, a mediator of innate lung immunity, alters the products of nitric oxide metabolism. Am J Respir Cell Mol Biol 2004; 30: 271-279.
  22. Малышев И.Ю., Лямина С.В., Шимшелашвили Ш.Л., Вассерман Е.Н. Функциональные ответы альвеолярных макрофагов, сурфактантный белок D и заболевания легких. Пульмонология 2011; 3: 101-107.
  23. Wert S. E., Yoshida M., LeVine A.M. et al. Proc Natl Acad Sci USA 2000; 97: 5972-5977.
  24. Botas C., Poulain F., Akiyama J. et al. Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D Proc Natl Acad Sci USA 1998; 95:11 869-11 874.
  25. Fujita M., Shannon J.M., Ouchi H. et al. Serum surfactant protein D is increased in acute and chronic inflammation in mice. Cytokine 2005; 31: 25-33.
  26. Fisher J.H., Larson J., Cool C., Dow S.W. Lymphocyte activation in the lungs of SP-D null mice. Am J Respir Cell Mol Biol 2002; 27: 24-33.
  27. LeVine A.M., Whitsett J.A., Gwozdz J.A. et al. Distinct effects of surfactant protein A or D deficiency during bacterial infection on the lung. J Immunol 2000; 165: 3934-3940.
  28. Gordon S. The macrophage: Past, present and future. Eur J Immunol 2007; 37: 9- 11.
  29. Kuan S., Rust K., Crouch E. Interactions of surfactant protein D with bacterial lipopolysaccharides. J Clin Invest 1992; 90: 97-106.
  30. McCormack F.X., Whitsett J.A. The pulmonary collectins, SP-A and SP-D, orchestrate innate immunity in the lung. J Clin Invest 2002; 109 (6): 707-712.
  31. Sin D.D., Pahlavan P.S., Man P.S.P. Surfactant protein D: A lung specific biomarker in COPD?: Potential biological roles of SP-D in COPD. Ther Adv Respir Dis 2008; 2 (2): 65-74.
  32. Eisner M.D., Parsons P., Matthay M.A. et al. Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury. Thorax 2003; 58: 983-988.
  33. Sorensen GL., Husby S., Holmskov U. Surfactant protein A and surfactant protein D variation in pulmonary disease. Immunobiology 2007; 212: 381-416.
  34. Mikerov A.N., Haque R., Gan X. et al. Ablation of SP-A has a negative impact on the susceptibility of mice to Klebsiella pneumoniae infection after ozone exposure: sex differences. Respir Res 2008; 9: 77.
  35. LeVine A.M., Bruno M.D., Huelsman K.M. et al. Surfactant protein A-deficient mice are susceptible to group B streptococcal infection. J Immunol 1997; 158: 4336-4340.
  36. LeVine A.M., Kurak K.E., Bruno M.D. et al. Surfactant protein-A-deficient mice are susceptible to Pseudomonas aeruginosa infection. Am J Respir Сell Mol Вiol 1998; 19: 700-708.
  37. LeVine A.M., Whitsett J.A., Gwozdz J.A. et al. Distinct effects of surfactant protein A or D deficiency during bacterial infection on the lung. J Immunol 2000; 165: 3934-3940.
  38. Linke M.J., Harris C.E., Korfhagen T.R. et al. Immunosuppressed surfactant protein A-deficient mice have increased susceptibility to Pneumocystis carinii infection. J Infect Dis 2001; 183: 943-952.
  39. Crouch E.C. Structure, biologic properties and expression of surfactant protein D. Biochim Biophys Acta 1998; 1408: 278-289.
  40. Gold J.A, Hoshino Y., Tanaka N. et al. Surfactant protein A modulates the inflammatory response in macrophages during tuberculosis. Infect Immun 2004; 72 (2): 645-650.
  41. Hu H., Teng G.L., Gai L.Z. et al. Clinical value of surfactant protein-A in serum and sputum for pulmonary tuberculosis diagnosis. Genet Mol Res 2013; 12 (4): 4918-4924.
  42. Hull J., South M., Phelan P., Grimwood K. Surfactant composition in infants and young children with cystic fibrosis. Am J Respir Crit Care Med 1997; 156: 161-165.
  43. Meyer K.C., Sharma A., Brown R. et al. Function and composition of pulmonary surfactant and surfactant-derived fatty acid profiles are altered in young adults with cystic fibrosis. Chest 2000; 118: 164-174.
  44. Kotecha S., Doull I., Davies P. et al. Functional heterogeneity of pulmonary surfactant protein-D in cystic fibrosis. Biochim Biophys Acta 2013; 1832(12): 2391-2400.
  45. Кrane M., Griese M. Surfactant protein D in serum from patients with allergic bronchopulmonary aspergillosis. Eur Respir J 2003; 22: 592-595.
  46. Behera D., Balamugesh T., Venkateswarlu D. et al. Serum surfactant protein-A levels in chronic bronchitis and its relation to smoking. Indian J Chest Dis Allied Sci 2005; 47: 13-17.
  47. Berthoin K., Broeckaert F., Robin M. et al. Serum pneumoproteins and biomarkers of exposure to urban air pollution: a cross-sectional comparison of policemen and foresters. Biomarkers 2004; 9: 341-352.
  48. Mutti A., Corradi M., Goldoni M. et al. Exhaled metallic elements and serum pneumoproteins in asymptomatic smokers and patients with COPD or asthma. Chest 2006; 129: 1288-1297.
  49. Sorensen G.L., Madsen J., Kejling K. et al. Surfactant protein D is proatherogenic in mice. Am J Physiol Heart Circ Physiol 2006; 290: H2286-H2294.
  50. Sin D.D., Leung R., Gan W.Q et al. Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study. BMC Pulmonary Med 2007; 7: 13.
  51. Ozyurek B.A., Ulasli S.S., Bozbas S.S. Value of serum and induced sputum surfactant protein-D in chronic obstructive pulmonary disease. Multidisciplinary Respir Med 2013; 8: 36.
  52. Cheng G., Ueda T., Numao T. et al. Increased levels of surfactant protein A and D in bronchoalveolar lavage fluids in patients with bronchial asthma. Eur Respir J 2000; 16: 831-835.
  53. Koopmans J.G., van der Zee, Krop J.S. et al. Serum surfactant protein D is elevated in allergic patients. Clin Exp Allergy 2004; 34: 1827-1833.
  54. Inase N., Ohtani Y., Sumi Y. et al. A clinical study of hypersensitivity pneumonitis presumably caused by feather duvets. Ann Allergy Asthma Immunol 2006; 96: 98-104.
  55. Cheng I.W., Ware L.B., Greene K.E. et al. Prognostic value of surfactant proteins A and D in patients with acute lung injury. Crit Care Med 2003; 31: 20-27.
  56. Лямина С.В., Веденикин Т.Ю., Малышев И.Ю. Современный подход к анализу иммунного ответа при заболеваниях легких: сурфактантный белок D и его роль. Современные проблемы науки и образования; URL: www.science-education.ru/98-4717 (дата обращения: 12.02.2014).
  57. Madan T., Kishore U., Singh M. et al. Surfactant proteins A and D protect mice against pulmonary hypersensitivity induced by Aspergillus fumigatus antigens and allergens. J Clin Invest 2001; 107: 467-475.
  58. Huang H., Peng X., Nakajima J. Advances in the study of biomarkers of idiopathic pulmonary fibrosis in Japan. Biosci Trends 2013; 7 (4): 172-177.
  59. Baughman R.P., Sternberg R.I., Hull W. Decreased surfactant protein A in patients with bacterial pneumonia. Am Rev Respir Dis 1993; 147 (3): 653-657.
  60. Yamaya Y., Suzuki K., Watari T., Asano R. Bronchoalveolar Lavage Fluid and Serum Canine Surfactant Protein A Concentrations in Dogs with Chronic Cough by Bronchial and Interstitial Lung Diseases. URL: www.ncbi.nlm.nih.gov/pubmed/24366151 (дата обращения 02.02.2014).
  61. Kunitake R., Kuwano K., Yoshida K. et al. KL-6, surfactant protein A and D in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis. Respiration 2001; 68: 488-495.
  62. Korfhagen T.R., Sheftelyevich V., Burhans M.S. et al. Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo. J Biol Chem 1998; 273: 28 438-28 443.
  63. Janssen R., Sato H., Grutters J.C. et al. Study of Clara cell 16, KL-6, and surfactant protein-D in serum as disease markers in pulmonary sarcoidosis. Chest 2003; 124: 2119-2125.
  64. Yao H.Y., Wang W., Zhang P.H. et al. Determination and clinical significance of serum surfactant proteins A and D in children with bronchiolitis. Zhongguo Dang Dai Er Ke Za Zhi 2013;15 (11): 987-989.
  65. Betsuyaku T., Kuroki Y., Nagai K. et al. Effects of ageing and smoking on SP-A and SP-D levels in bronchoalveolar lavage fluid. Eur Respir J 2004; 24: 964-970.
  66. Wulf-Johansson H., Thinggaard M., Tan Q. et al. Circulating surfactant protein D is associated to mortality in elderly women: A twin study Original Research. Immunobiology 2013; 218 (5): 712-717.
  67. Hill J., Heslop C., Man S.F. et al. Circulating surfactant protein-D and the risk of cardiovascular morbidity and mortality. Eur Heart J 2011; 32: 1918-1925.

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