Association of Т174М polymorphism of the angiotensinogen gene with the higher risk of cerebral stroke in women
- Authors: Stetskaia TA1, Bushueva OI.1, Bulgakova IV1, Vialykh EK1, Shuteeva TV1, Biriukov AE1, Ivanov VP1, Polonikov AV1
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Affiliations:
- Issue: Vol 86, No 12 (2014)
- Pages: 66-71
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/31624
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Abstract
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Ассоциация полиморфизма Т174М гена ангиотензиногена с повышенным риском развития мозгового инсульта у женщин. - Резюме. Цель исследования. Изучение ассоциации полиморфизмов M235T (rs699) и T174M (rs4762) гена ангиотензиногена (AGT) с риском развития мозгового инсульта (МИ) у русских жителей Центрального Черноземья. Материалы и методы. Исследовали 638 образцов ДНК 353 пациентов с МИ и 285 здоровых индивидуумов соответствующего пола и возраста. Генотипирование полиморфизмов проводили методами полимеразной цепной реакции (T174M) и аллельной дискриминации с помощью TaqMan-зондов (M235T). Результаты. Выявлено, что у носителей гетерозиготного генотипа 174TM гена AGT повышен риск развития МИ (отношение шансов - ОШ - 1,52 при 95% доверительном интервале - ДИ - от 1,08 до 2,15; р=0,02). Стратифицированный анализ по полу показал, что мутантный аллель 174M (ОШ 1,86 при 95% ДИ от 1,14 до 3,03; р=0,01), а также вариантные генотипы 174TM и 174MM (ОШ 1,86 при 95% ДИ от 1,09 до 3,20; р=0,02) ассоциированы с повышенным риском развития МИ у женщин. Заключение. Впервые обнаружена связь полиморфизма T174M гена AGT с риском развития МИ, но повышенный риск развития заболевания у носителей вариантных аллелей и генотипов наблюдается только у женщин.About the authors
T A Stetskaia
O Iu Bushueva
Email: olga.bushueva@inbox.ru
I V Bulgakova
E K Vialykh
T V Shuteeva
A E Biriukov
V P Ivanov
A V Polonikov
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