Use of anti-B-cell therapy in case of antisynthetase syndrome as the severest subtype of polymyositis/dermatomyositis


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Abstract

Antisynthetase syndrome encompassing a symptom complex with severe interstitial lung disease is the severest subtype of polymyositis and dermatomyositis. The characteristic feature of antisynthetase syndrome is the insufficient efficiency of traditional therapy with glucocorticosteroids and cytostatics, which determines the prognosis of the disease and the need for new therapeutic approaches to treating these patients.

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Применение анти-В-клеточной терапии при антисинтетазном синдроме как наиболее тяжелом подтипе полимиозита/дерматомиозита. - Аннотация. Наиболее тяжелым подтипом полимиозита и дерматомиозита является антисинтетазный синдром, включающий симптомокомплекс с тяжелым интерстициальным поражением легких. Характерная особенность антисинтетазного синдрома заключается в недостаточной эффективности традиционной терапии глюкокортикостероидами и цитостатиками, что определяет прогноз болезни и обусловливает необходимость поиска новых терапевтических подходов к лечению этих пациентов.
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