Pain treatment in patients with hemophilia


Cite item

Full Text

Abstract

Pain in patients with hemophilia is an urgent problem. The possibilities of using analgesic drugs are interesting by virtue of the specific features of pain syndrome and the problems of treatment in these patients. Foreign and Russian trials using current analgesics are analyzed; difficulties in choosing analgesic therapy and in performing anesthesia mode in patients with congenital hypocoagulation and hyperalgesia are discussed.

Full Text

Лечение боли у пациентов с гемофилией. - Аннотация. Боль у пациентов с гемофилией является актуальной проблемой. Интересны возможности применения анальгетических препаратов ввиду особенностей болевого синдрома и проблем лечения у этих больных. Представлены анализ зарубежных и российских исследований по применению современных анальгетиков, обсуждаются трудности подбора обезболивающей терапии и проведения анестезиологического пособия у пациентов с врожденной гипокоагуляцией и гипералгезией.
×

About the authors

O K Levchenko

References

  1. Elander J., Barry T. Analgesic use and pain coping among patients with haemophilia. Haemophilia 2003; 9 (2): 202-213.
  2. Плющ О.П., Копылов К.Г. Амбулаторное лечение больных гемофилией и болезнью Виллебранда. Гематол и трансфузиол 2002; 3: 30-34.
  3. Андреев Ю.Н. Многоликая гемофилия. М: Ньюдиамед; 2006.
  4. Polomano R., Dunwoody C., Krenzischer D. Perspective on pain management in the 21st century. Pain Management Nurs 2008; 9: 3-10.
  5. Witkop M., Lambing A., Divine G. et al. A national study of pain in the bleeding disorders community: a description of haemophilia pain. Haemophilia 2012; 18 (3): 115-119.
  6. Wheeler M., Oderda G.M., Ashburn M.A. et al. Adverse events associated with postoperative opioid analgesia: a systematic review. Pain 2002; 3 (3): 159-180.
  7. Rundshagen I. Drug addiction and anaesthesia: most popular recreational drugs in Germany and anaesthesiological management of drug addicts. Anasthesiol Intensivmed Notfallmed Schmerzther 2010; 45 (5): 304-313.
  8. Овечкин А.М., Ефременко И.В. Фармакотерапия острой послеоперационной боли, основанная на применении препаратов, воздействующих на NMDA-рецепторный комплекс. Анестезиол и реаниматол 2013; 3: 63-69.
  9. Peng P.W., Wijeysundera D.N., Li C.C. Use of gabapentin for perioperative pain control - a meta-analysis. Pain Res Manag 2007; 12 (2): 85-92.
  10. Блажиевич И.А., Поспелова Т.И. Терапевтические проблемы больных гемофилией. Бюл сиб мед 2008; приложение 2: 9-10.
  11. Massó González E.L., Patrignani P., Tacconelli S. et al. Variability among nonsteroidal antiinflammatory drugs in risk of upper gastrointestinal bleeding. Arthritis Rheum 2010; 62 (6): 1592-1601.
  12. Inwood M.J., Killackey B., Startup S.J. The use and safety of Ibuprofen in the hemophiliac. Blood 1983; 61 (4): 709-711.
  13. Rattray B., Nugent D.J., Young G. Rofecoxib as adjunctive therapy for haemophilic arthropathy. Haemophilia 2005; 11 (3): 240-244.
  14. Rattray B., Nugent D.J., Young G. Celecoxib in the treatment of haemophilic synovitis, target joints, and pain in adults and children with haemophilia. Haemophilia 2006; 12: 514-517.
  15. Srivastava A., Brewer K., Mauser-Bunschoten E.P. et al. Guidelines for the management of hemophilia. Haemophilia 2013; 19 (1): 1-47.
  16. Rumack B.H. Acetaminophen hepatoxicity: the first 35 years. J Toxicol Clin Toxicol 2002; 40: 3-20.
  17. VanVeen J.J., Gleeson D.C., Makris M. Рaracetamol/acetaminophen usage in haemophilia: more caution needed? Haemophilia 2008; 14 (3): 434-435.
  18. Grady J.G. Droadening the view of acetaminophen hepatotoxicity. Hepatology 2005; 42: 1252-1254.
  19. Barbaro G., Di Lorenzo G., Soldini M. et al. Hepatic glutathione deficiency in chronic hepatitis C quantitative evaluation in patients who are HIV positive and HIV negative and correlations with plasmatic and lymphocytic concentrations and with the activity of the liver disease. Am J Gastroenterol 1996; 91: 2569-2573.
  20. Kuffner E.K., Temple A.R., Cooper K.M. et al. Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials. Curr Med Res Opin 2006; 22: 2137-2148.
  21. Снегирева-Давыденко И.Б., Плющ О.П. Парентеральные вирусные гепатиты B, C, G и ТТ у больных гемофилией широта распространения, особенности течения и терапии. Гематол и трансфузиол 2002; 3: 20-23.
  22. DuManoir B., Aubrun F., Langlois M. Randomized prospective study of the analgesic effect of nefopam after orthopaedic surgery. Br J Anaesth 2003; 91: 836-841.
  23. Delage N., Maaliki H., Beloeil H. Median effective dose (ED50) of nefopam and ketoprofen in postoperative patients. Anesthesiology 2005; 102: 1211-1216.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2014 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 

Address of the Editorial Office:

  • Novij Zykovskij proezd, 3, 40, Moscow, 125167

Correspondence address:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Managing Editor:

  • Tel.: +7 (926) 905-41-26
  • E-mail: e.gorbacheva@ter-arkhiv.ru

 

© 2018-2021 "Consilium Medicum" Publishing house


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies