Email this article Current possibilities of correcting subchondral bone resorption as a major pathogenetic factor for progressive osteoarthrosis
- Authors: Naumov AV1
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Affiliations:
- Issue: Vol 86, No 1 (2014)
- Pages: 60-65
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/31434
- ID: 31434
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Abstract
The paper considers the current pathogenesis, by choosing the actual targets of pharmacotherapy with available drugs. It reflects the cytokine mechanisms responsible for lesion of the synovial membranes, cartilage, and subchondral bone. Particular emphasis is laid on the role of chondroitin sulfate, glucosamine, vitamin D3 as drugs that affect the key components of pathogenesis, including the volume of resorptive cavities in the subchondral bone.
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Современные возможности коррекции резорбции субхондральной кости как главного патогенетического фактора прогрессирования остеоартроза. - Аннотация. В статье рассматривается современный патогенез остеоартроза с точки зрения выбора актуальных мишеней фармакотерапии доступными лекарственными средствами. Отражены цитокиновые механизмы повреждения синовиальной оболочки, хряща и субхондральной кости. Особое внимание уделено роли резорбции субхондральной кости в патогенезе остеоартроза. Представлена роль хондроитина сульфата, глюкозамина и витамина D3 как препаратов, влияющих на ключевые звенья патогенеза, в том числе на объем резорбтивных полостей в субхондральной кости.×
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