Sepsis: a new look at the problem


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Abstract

The recent proceedings of congresses and forums on sepsis were used to write this review. The available definitions of sepsis and ideas on its etiology and pathogenesis are critically analyzed. There is information on new concepts of sepsis and data on a search for new targets, diagnostic and therapeutic approaches, and biomarkers. It is hypothesized that there is a mechanism of action of bacteria on mitochondrial dysfunction and human hormonal regulation with low-molecular weight exometabolites, namely aromatic microbial metabolites.

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Сепсис: новый взгляд на проблему. - Аннотация. При написании обзора использовались материалы конгрессов и форумов по вопросам сепсиса, полученные в последние годы. Проведен критический анализ существующих определений сепсиса и представлений о его этиологии и патогенезе. Дана информация о новых концепциях сепсиса, приведены данные о поиске новых мишеней, диагностических и лечебных подходах, биомаркерах. Выдвинута гипотеза о механизме влияния бактерий на дисфункцию митохондрий и гормональную регуляцию в организме человека посредством низкомолекулярных экзометаболитов, а именно ароматических микробных метаболитов.
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About the authors

N V Beloborodova

Email: nvbeloborodova@yandex.ru

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