Vascular stiffness and diastolic heart failure


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Abstract

Vascular stiffness is regarded as a result of degenerative processes potentiated by aging, hypertension, and other risk factors. Central hemodynamic changes are one of the serious sequels of high arterial stiffness, which gives rise to a chain of events as a higher postload on the left ventricle, its concentric hypertrophy, diastolic dysfunction and increases the overall risk of cardiovascular events. The purpose of the review is to discuss the mechanisms of vascular stiffness, focusing on the role of this condition in the development of chronic heart failure with retained ejection fraction and its pathogenetic treatment as a future target.

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Жесткость сосудов и диастолическая сердечная недостаточность. - Аннотация. Жесткость сосудов рассматривается как результат дегенеративных процессов, потенцируемых старением, артериальной гипертонией и другими факторами риска. Одно из серьезных последствий высокой жесткости артерий - изменение центральной гемодинамики, что дает начало цепи событий в виде увеличения посленагрузки на левый желудочек, его концентрической гипертрофии, диастолической дисфункции и увеличивает общий риск развития сердечно-сосудистых осложнений. Цель обзора - обсуждение механизмов жесткости сосудов, фокусируя внимание на роль этого состояния в развитии хронической сердечной недостаточности с сохраненной фракцией выброса и в качестве будущей мишени ее патогенетического лечения.
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About the authors

O M Drapkina

Email: drapkina@bk.ru

A N Kaburova

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