The course of parvovirus B19 infection during pregnancy after kidney transplantation


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Abstract

Having a tropism for erythroid progenitor cells, parvovirus B19 may cause partial red cell aplasia and thrombocytopenia. Early diagnosis of parvovirus B19 infection in immunocompromised patients is needed for timely antiviral therapy. A high-risk group for parvovirus B19 infection includes patients with blood diseases who receive multiple transfusions of blood components; those who have undergone donor organ transplantation and are long taking immunosuppressive drugs; and pregnant women. These patients require careful virological monitoring for major blood-borne viral infections. This paper describes a clinical case of parvovirus B19 infection in a pregnant woman who has undergone kidney transplantation and is continuously taking immunosuppressive medications. Identification of the cause of severe anemia and timely adequate therapy could lead to the recovery of effective erythropoiesis in the patient.

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Особенности течения инфекции парвовируса В19 во время беременности после трансплантации почки. - Аннотация. Парвовирус В19 (PV B19), обладая тропизмом к клеткам-предшественницам эритропоэза, может быть причиной развития парциальной красноклеточной аплазии с тромбоцитопенией. Ранняя диагностика инфицирования парвовирусом В19 больных с нарушениями иммунитета необходима для своевременного проведения противовирусной терапии. К группе высокого риска инфицирования парвовирусом В19 относятся больные с заболеваниями системы крови, получающие многочисленные трансфузии компонентов крови; больные, перенесшие трансплантацию донорских органов и длительное время принимающие иммуносупрессивные препараты, а также беременные. Эти пациенты нуждаются в тщательном мониторинге вирусологического статуса по основным гемотрансмиссивным вирусным инфекциям. В данной работе описан клинический случай инфицирования парвовирусом В19 беременной, перенесшей трансплантацию почки и постоянно получающей иммуносупрессивные препараты. Выявление причины тяжелой анемии и своевременная адекватная терапия позволили добиться у больной восстановления эффективного эритропоэза.
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