Successful use of vemurafenib in a patient with resistant hairy cell leukemia

Abstract

The paper describes a case of a patient with refractory hairy cell leukemia. In spite of the absence of CD25 expression, the disease was classified as a classical form according to the WHO classification (2008), as also confirmed by the detection of BRAFV600E mutation. The disease was characterized by resistance to all lines of therapy (interferon-α, splenectomy, cladribin). Clinical and hematological remission was achieved within 2 months of administration of the BRAF kinase inhibitor vemurafenib.

Full Text

Успешное применение вемурафениба у больного с резистентной формой волосатоклеточного лейкоза. - Аннотация. Представлено наблюдение за пациентом с рефрактерным течением волосатоклеточного лейкоза. Несмотря на отсутствие экспрессии СD25, в соответствии с классификацией ВОЗ (2008) заболевание отнесено к классической форме, что также подтверждено выявлением мутации BRAFV600E. Течение заболевания характеризовалось резистентностью к терапии всех линий (интерферон-α, спленэктомия, кладрибин). В результате применения ингибитора BRAF-киназы вемурафениба в течение 2 мес достигнута клинико-гематологическая ремиссия заболевания.
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Copyright (c) 2013 Urnova E.S., Al'-Radi L.S., Kuz'mina L.A., Kariakina A.A., Kovrigina A.M., Dvirnyk V.N., Iakutik I.A., Sudarikov A.B., Parovichnikova E.N., Savchenko V.G.

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