Email this article Component-resolved diagnosis is a new era in clinical allergology
- Authors: Mokronosova MA1, Korovkina ES1
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Affiliations:
- Issue: Vol 85, No 10 (2013)
- Pages: 4-8
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/31309
- ID: 31309
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Abstract
The paper describes the fundamentals and benefits of a new allergy diagnostic technique based on recent advances in molecular biology and biotechnology. Component-resolved diagnosis allows IgE antibodies against purified molecules (individual allergen components) to be revealed. Microanalysis is made using microarrays with applied molecules (allergen components) obtained in a recombinant fashion or extracted from natural raw materials. The authors present a current classification of animal and plant allergens and show the value of component-resolved diagnosis in clinical practice, by using specific clinical examples.
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Компонентная диагностика - новая эра в клинической аллергологии. - Аннотация. В статье описаны основы и преимущества нового метода аллергодиагностики, базирующегося на современных достижениях молекулярной биологии и биотехнологии. Метод компонентной диагностики позволяет выявлять наличие антител класса иммуноглобулина E к очищенным молекулам (отдельным компонентам аллергенов). Микроанализ проводят с применением биочипов с нанесенными на них молекулами (компонентами аллергенов), полученными рекомбинантным путем или выделенными из натурального сырья. Приведена современная классификация аллергенов животного и растительного происхождения и показано значение компонентной диагностики в клинической практике на конкретных клинических примерах.×
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