Melatonin and metabolic syndrome: Is there their association?


The basis for the current view of the mechanisms for regulating metabolic processes is the hypothesis proposed by the United Kingdom scientists E. Scott and P. Grant that evolutionary fixed adaptation to seasonal environmental changes is impaired. Under the hypothesis, impairment in seasonal and circadian rhythms is the key condition for the occurrence of obesity, arterial hypertension (AH), and type 2 diabetes mellitus. The diseases of civilization, namely obesity, insulin resistance, and AH, are a direct result of chronic metabolic disturbance due to light pollution.

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Мелатонин и метаболический синдром: существует ли связь?. - Аннотация. В основе современного взгляда на механизмы регуляции метаболических процессов лежит гипотеза о нарушении эволюционно закрепленной адаптации к сезонным изменениям окружающей среды, предложенная английскими учеными E. Scott и P. Grant. Согласно гипотезе нарушение сезонных и суточных ритмов является основным условием для возникновения ожирения, артериальной гипертонии (АГ) и сахарного диабета 2-го типа. "Болезни цивилизации" - ожирение, инсулинорезистентность и АГ - являются прямым следствием хронического нарушения метаболизма в результате "световой загрязненности".


  1. Физиология человека. Руководство в 4 томах. Под ред. R.S. Schidt, G. Thew. Т.1. M: Мир 1985: 232-234.
  2. Lincoln G.A., Richardson M. Photo-neuroendocrine control of seasonal cycles in body weight, pelage growth and reproduction: lessons from the HPD sheep model. Comp Biochem Physiol Cl Pharmacol Toxicol Endocrinol 1998; 119 (3): 283-294.
  3. Дедов И.И., Дедов В.И. Биоритмы гормонов. М: Медицина 1992; 255.
  4. Ferrari E., Fraschini F., Brambilla F. Hormonal circadian rhythms in eating disorders. Biol Psychiatr1990; 27 (9): 1007-1020.
  5. Morgan L., Hampton S., Gibbs M., Arendt J. Circadian aspects of postprandial metabolism. Chronobiol Int 2003; 20 (5): 795-808.
  6. Lundi J., Arendt J., Hampton S.M. et al. Postprandial hormone and metabolic responses amongst shift workers in Antarctica. J Endocrinol 2001; 171 (3): 557-564.
  7. Nussey S., Whitehead S. An Integrated Approach. Endocrinology. Oxford: BIOS Scientific Publishers Limited 2001.
  8. Wehr T.A. Photoperiodism in humans and other primates: evidence and implications. J Biol Rhythms 2001; 16: 348-364.
  9. Ando H., Yanagihara H., Hayashi Y. et al. Rhythmic mRNA expression of clock genes and adipocytokines in mouse visceral adipose tissue. Endocrinology 2005; 146 (12): 5631-5636.
  10. Macchi M.M., Bruce J.N. Human pineal physiology and functional significance of melatonin. Front Neuroendocrinol 2004; 25 (3-4): 177-195.
  11. Anton M. Jetten Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl Recept Signal 2009; 7: e003.
  12. Maenura K., Taceda N., Nagai R. Circardian Rhythms in CNS and Peripheral Clock Disorders: Role of the Biological Clock in cardiovascular diseases. J Farmocol Science 2007; 103: 134-138.
  13. Anhě G.F., Caperuto L.C., Pereira-Da-Silva M. et al. In vivo activation of insulin receptor tyrosine kinase by melatonin in the rat hypothalamus. J Neurochem 2004; 90 (3): 559-566.
  14. Mühlbauer E., Gross E., Labucay K. et al. Loss of melatonin signaling and its impact on circadian rhythms in mouse organs regulalating blood glucose. Eur J Pharmacol 2009; 606 (1-3): 61-71.
  15. Palatini P. Non-dipping in hypertension: still a challenging problem. J Hypertens 2004; 22: 2269-72.
  16. Reiter R.J., Tan D.X., Korkmaz A. The circadian melatonin rhythm and its modulation: possible impact on hypertension. J Hypertens 2009; 27 (Suppl. 6): 17-20.
  17. Wolden-Hanson T., Mitton D.R., McCants R.L. et al. Daily melatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat. Endocrinology 2000; 141 (2): 487-497.
  18. Millar-Craig M.W., Bishop C.N., Raftery E.B. Circadian variation of blood-pressure. Lancet 1978; 1: 795-797.
  19. Kotsis V., Stabouli S., Bouldin M. et al. Impact of obesity on 24-hour ambulatory blood pressure and hypertension. Hypertension 2005; 45 (4): 602-607.
  20. Anan F., Takahashi N., Ooie T. et al. Role of insulin resistance in non-dipper essential hypertensive patients. Hypertens Res 2003; 26 (9): 669-676.
  21. Мелатонин в норме и патологии. Под ред. Ф.И. Комарова. М: Медпрактика 2004; 308.
  22. Simko F., Paulis L. Melatonin as a potential antihypertensive treatment. J Pineal Res 2007; 42: 319-322.
  23. Kawashima K., Nagakura A., Wurzburger R.J., Spector S. Melatonin in serum and the pineal of spontaneously hypertensive rats. Clin Exp Hypertens A 1984; 6 (8): 1517-1528.
  24. Kawashima K., Miwa Y., Fujimoto K. et al. Antihypertensive action of melatonin in the spontaneously hypertensive rat. Clin Exp Hypertens A 1987; 9 (7): 1121-1131.
  25. Jonas M., Garfinkel D., Zisapel N. et al. Impaired nocturnal melatonin secretion in non-dipper hypertensive patients. Blood Press 2003; 12 (1): 19-24.
  26. Заславская Р.М., Логвиненко С.И., Лилица Г.В., Щербань Э.А. Мелатонин в комплексной терапии сердечно-сосудистых заболеваний. Клин мед 2010; 3: 26-30.
  27. Физиология человека. Руководство в 4 томах. Под ред. R.S. Schidt, G. Thew. Т.1. M: Мир 1985; 266.
  28. Klein D.C., Moore R.Y., Reppert S.M. Suprachiasmatic Nucleus: The Mind's Clock. New York: Oxford University Press 1991; 467.
  29. Berson D.M., Dunn F.A., Takao M. Phototransduction by retinal ganglion cells that set the circadian clock. Science 2002; 295: 1070-1073.
  30. Turek F.W., Joshu C., Kohsaka A. et al. Obesity and metabolic syndrome in circadian Clock mutant mice. Science 2005; 308 (5724): 1043-1045.
  31. Shimba S., Ishii N., Ohta Y. et al. Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis. Proc Natl Acad Sci U.S.A. 2005; 102: 12 071-12 076.
  32. Reiter R.J., Tan D.X., Manchester L.C. et al. Medical implications of melatonin: receptor-mediated and receptor-independent actions. Adv Med Sci 2007; 52: 11-28.
  33. Witz P.H., Bärtschi C., Spillmann M. et al. Effect of oral melatonin on procoagulant response to acute psychosocial stress in healthy men a randomized placebo-controlled study. J Pineal Res 2008; 44 (4): 358-365.
  34. Kreier F., Yilmaz A., Kalsbeek A. et al. Hypothesis: shifting the equilibrium from activity to food leads to autonomic unbalance and metabolic syndrome. Diabetes. 2003; 52: 2652-2656.



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