Sexual dysfunction induced by antidepressants and antipsychotics


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Abstract

The interest in sexual dysfunction induced by psychotropic drugs has increased considerably in recent years because of the new-generation antidepressants (AD) and antipsychotics (AP) being put into medical practice. These drugs are widely used to treat not only depression and schizophrenia, but also anxiety and affective disorders. Other, additional indications for the use of antidepressants are appetite disorders, premenstrual syndrome, chronic pain, etc. Neuroleptics are administered to treat resistant depressions, aggressiveness, impulsivity, and alcoholism. Impaired sexual functioning due to AD and AP lowers quality of life in patients and increases the risk of their refusing treatment, the result of which is a phenomenon associated with the occurrence of recurrent mental illnesses. There are few scientific data on the nature and prevalence of sexual dysfunctions induced by these medications. This topic is universally underestimated as it is rarely touched upon by specialists during their consultations. The aim of the review is to show the side effects of AP and AD on the sexual sphere, to compare different classes of the drugs, and to propose possible management strategies to correct these undesirable effects.

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Нарушения половой функции, индуцированные антидепрессантами и антипсихотическими средствами. - Аннотация. Внимание к нарушениям половой функции как следствиям применения психотропных средств значительно выросло за последнее время в связи с введением антидепрессантов и нейролептиков нового поколения в медицинскую практику. Эти препараты широко используются для лечения не только депрессии, шизофрении, но и тревожных и аффективных расстройств. Другие дополнительные показания к применению антидепрессантов - нарушения аппетита, предменструальный синдром, хроническая боль и др. Нейролептики в свою очередь используются для лечения резистентных депрессий, агрессивного поведения, импульсивности, алкоголизма. Нарушения половой функции, индуцированные антидепрессантами и антипсихотическими средствами, снижают качество жизни пациентов и повышают риск отказа их от лечения, результатом чего является феномен, ассоциированный с проблемой рецидивов психических заболеваний. Существует не много научных данных о природе и распространенности половых дисфункций, индуцированных этими лекарственными препаратами. Эта тема повсеместно недооценивается, так как редко затрагивается специалистами на консультации. Цель обзора - показать побочные влияния на половую сферу антидепрессантов и антипсихотических средств, сравнить различные классы препаратов и предложить возможные тактики лечения, корректирующие эти нежелательные эффекты.
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References

  1. Baldwin D.S. Depression and sexual dysfunction. Br Med Bul 2001; 57: 81-99.
  2. Segraves R.T. Dealing with sexual side effects. Harv Ment Health Lett 2008; 2 4 (11): 6-14.
  3. Spector I.P., Carey M.P. Incidence and prevalence of the sexual dysfunction: a critical review of the empirical literature. Arch Sex Behav 1990; 19: 389-408.
  4. Clayton A.H., McGarvey E.L., Clavet G.J. The Changes in Sexual Functioning Questionnaire (CSFQ): Development, Reliability, and Validity. Psychopharmacol Bul 1997; 33 (4): 731-745.
  5. McGahuey C.A., Gelenberg A.J., Laukes C.A. et al. The Arizona sexual experience scale (ASEX): validity and reliability. J Sex Marital Ther 2000; 26: 25-40.
  6. Serretti A., Chiesa A. Sexual side effects of pharmacological treatment of psychiatric diseases. Clin Pharmacol Ther 2011; 89: 142-147.
  7. Casper R.C., Redmond E., Katz M.M., Schaffer C.B. Somatic symptoms in primary affective disorders: presence and relationship to the classification of depression. Arch Gen Psychiatry 1985; 42: 1098-1104.
  8. Baggaley M. Sexual dysfunction in schizophrenia: focus on recent evidence. Hum Psychopharmacol Clin Exp 2008; 23: 201-209.
  9. Montejo-Gonzalez A.L., Liorca G., Isquierdo J.A. et al. SSRI-induced sexual-dysfunction: fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. J Sex Marital Ther 1997; 23: 176-194.
  10. Balon R., Segraves R.T. Clinical Manual of Sexual Disordres. American Psychiatric Publishing, Inc. Washington, DC London, England 2009: 95-115.
  11. American Psychiatric Association. DSM-IV-TR. Manuel diagnostique et statistique des troubles mentaux: Texte révisié [Broché] Masson 2003; 617-675.
  12. Montejo A.L., Riesgo Y., Luque J. et al. Observational, open-label, prospective multicenter study of sexual function in patients starting treatment with aripiprazole. Actas Esp Psiquiat 2010; 38 (1): 13-21.
  13. Segraves R.T., Balon R. Sexual Pharmacology. Fast Facts. New York, London: W.W. Norton & Company 2003: 29-72.
  14. Bymaster F.P., Dreshfield-Ahmad L.J., Threlkeld P.G. et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo , human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology 2001; 25: 871-880.
  15. Licitsyna O., Ansseau M., Pitchot W. Dysfonctions sexuelles et antidépresseurs. Rev Med Liége 2011; 66 (2): 69-74.
  16. Kennedy S.H. Treating each and every depressed patient. J Psychopharmacology 2008; 22 (Suppl 7): 19-23.
  17. Kennedy S.H. Sexual Dysfunction, Depression, and the impact of antidepressants. J Clin Psychopharmacol 2009; 29: 157-164.
  18. Balon R. SSRI-Associated Sexual Dysfunction. Am J Psychiatry 2006; 163 (9): 1504-1509.
  19. Zajecka J.M. Augmentation strategies to increase antidepressant Tolerability. J Clin Psychiatry 2007; 68 (Suppl 10): 23-27.
  20. Werneke U., Northey S., Bhugra D. Antidepressants and sexual dysfunction. Acta Psychiatr Scand 2006; 114: 384-397.
  21. Taylor M.J., Rudkin L., Hawton K. Strategies for managing antidepressant-induced sexual dysfunction. Systematic review of randomized controlled trials. J Affective Disorders 2005; 88: 241-254.
  22. Segraves R.T. Sexual dysfunction associated with antidepressant. Ther Urol Clin North Am 2007; 34: 575-579.
  23. Serretti A., Chiesa A. A meta-analysis of sexual dysfunction in psychiatric patients taking antipsychotics. Intern Clin Psychopharmacol 2011; 26 (3): 130-140.
  24. Martin-Du Pan R., Baumann P. Dysfunctions sexuelles induites par les antidépresseurs et les antipsychotiques et leurs traitements. Revue Médicale Suisse 2008; 4: 758-762.
  25. Williams V.S., Edin H.M., Hogue S.L. et al. Prevalence and impact of antidepressant-associated sexual dysfunction in the three European countries: replication in a cross-sectional patient survey. J Psychopharmacol 2010; 24 (4): 489-496.

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