Single-photon emission computed tomography in the diagnosis of myocardial perfusion abnormalities in patients with rheumatoid arthritis: Preliminary data


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Abstract

Increased cardiovascular morbidity and mortality in patients with rheumatoid arthritis (RA) may be attributed to the fact that a systemic inflammation existing in this disease may trigger the development of atherosclerosis. 99mTc-MIBI (4,2-methoxyisobutyl isonitrile) is a compound that permits myocardial perfusion to be visualized and has been proposed for the evaluation of the latter in patients with RA. Analysis of the results of the studies revealed transient myocardial ischemia areas in patients who did not take methotrexate while those who used it were found to have diminished perfusion areas that were, however, clinical insignificant.

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Однофотонная эмиссионная компьютерная томография в диагностике нарушений перфузии миокарда у больных ревматоидным артритом (предварительные данные). - Аннотация. Повышение сердечно-сосудистой заболеваемости и смертности у пациентов с ревматоидным артритом (РА) может быть объяснено тем, что системное воспаление, имеющееся при этом заболевании, может ускорять развитие атеросклероза. 99mTc-МИБИ (4,2-метоксиизобутилизонитрила) является соединением, позволяющим визуализировать перфузию миокарда, и был предложен для оценки состояния перфузии миокарда у пациентов с РА. В ходе анализа результатов проведенных исследований выявлены участки преходящей ишемии миокарда у пациентов, которые не принимали метотрексат, в то время как у пациентов, принимавших этот препарат, также были выявлены участки снижения перфузии, однако клинически незначимые.
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References

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