Specific dynamic action of food in patients with chronic pancreatitis accompanied with metabolic syndrome

Full Text


Aim. To study hormone component of food specific dynamic action (FSDA) in chronic pancreatitis (CP) accompanied with metabolic syndrome (MS).
Material and methods. A total of 60 patients were examined: 30 patients with CP and 30 patients with CP accompanied with MS. The study of fasting levels of thyrotrophic hormone, thyroxin, cortisol, insulin, C-peptide was conducted as well as one and two hours after carbohydrate breakfast to assess development of FSDA.
Results. The study revealed that development of FSDA is characterized by systemic reaction, including changes in multiple hormonal parameters. However, patients with CP accompanied with MS demonstrated abnormal basal secretion and postprandial secretory responses of the above hormones. The absence of hormonal responses to food intake impairs FSDA and thus is involved in pathogenesis of metabolic disorders in patients with CP accompanied with MS.
Conclusion. The study of the development of FSDA brings valuable information that can be used in clinical practice for studying mechanisms of metabolic disorders in various pathological conditions.

About the authors

Yakov Maksimovich Vakhrushev

Anna Aleksandrovna Volkova

Email: annalogi@mail.ru

Ya M Vakhrushev

State Medical Academy, Izhevsk

State Medical Academy, Izhevsk

A A Volkova

State Medical Academy, Izhevsk

State Medical Academy, Izhevsk


  1. Егорова Е. Г., Звенигородская Л. А., Лазебник Л. Б. Метаболический синдром с позиции гастроэнтеролога. Рус. мед. журн. 2005; 13 (26): 1706-1712.
  2. Корочина И. Э. Гастроэнтерологические аспекты метаболического синдрома. Рос. журн. гастроэнтерол., гепатол., колопроктол. 2008; 18 (1): 26-34.
  3. Христич Т. Н., Кендзерская Т. Б. Поджелудочная железа при метаболическом синдроме. Экспер. и клин. гастроэнтерология 2010; 8: 83-91.
  4. Лазебник Л. Б., Звенигородская Л. А. Метаболический синдром и органы пищеварения. М.: Анахарсис; 2009.
  5. Вахрушев Я. М. Специфическое динамическое действие пищи. Ижевск: Экспертиза; 1996.
  6. Уголев А. М. Энтериновая (кишечная гормональная) система. Л.: Наука; 1978.
  7. Рекомендации экспертов ВНОК по диагностике и лечению метаболического синдрома / Чазова И. Е., Мычка В. Б., Кисляк О. А. и др. Второй пересмотр. М.; 2009.
  8. Reaven G. M. Insulin resistance and compensatory hyperinsulinemia role in hypertension, dyslipidemia and coronary heart disease. Am. Heart J. 1991; 1: 1283-1288.
  9. Reaven G. M. The metabolic syndrome: is this diagnosis necessary? Am. J. Clin. Nutr. 2006; 83 (6): 1237-1247.
  10. Чазова И. Е., Мычка В. Б. Метаболический синдром. М.: Медиа Медика; 2008.
  11. Yu Chin Cheng, Hua Hsu Ai, Qin Alex, Tong Chin. Neuroendocrine mechanisms in the pathophysiology of obesity. J. Psychiatr. Biol. Ther. 1990; 36: 26-33.



Abstract: 173

Article Metrics

Metrics Loading ...


  • There are currently no refbacks.

Copyright (c) 2012 Vakhrushev Y.M., Volkova A.A., Vakhrushev Y.M., Volkova A.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Address of the Editorial Office:

  • Novij Zykovskij proezd, 3, 40, Moscow, 125167

Correspondence address:

  • Novoslobodskaya str 31c4., Moscow, 127005, Russian Federation

Managing Editor:


© 2018-2021 "Consilium Medicum" Publishing house

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies