Email this article Prevalence of gluten-sensitive celiac disease in women with reproductive dysfunction
- Authors: Bykova S.V.1, Parfenov A.I.1, Tetruashvili N.K.1, Sabel'nikova E.A.1, Gudkova R.B.1, Krums LM1, Vorob'eva N.N.1, Repina E.A.1, Vityazeva I.I.1, Petukhova G.S.1, Bykova SV2, Parfenov AI2, Tetruashvili NK3, Sabelnikova EA2, Gudkova RB2, Krums LM2, Vorobyeva NN2, Repina EA4, Vityazeva IN4, Petukhova GS5
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Affiliations:
- Central Research Institute of Gastroenterology, Moscow
- Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Moscow
- Research Center for Endocrinology, Moscow
- Moscow Reproduction Center, Moscow
- Issue: Vol 84, No 2 (2012)
- Pages: 31-36
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30983
- ID: 30983
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Abstract
Material and methods. Tests for blood serum antibodies to tissue transglutaminase (ABtTG) of IgA class were made in 217 women with RD. Tests for antibodies to gliadin (ABG) were performed in 180 of them. Esophagogastroduodenoscopy (EGDS) with biopsy to verify GSCD was conducted in patients with elevated ABtTG. The control group consisted of 15 healthy females of a reproductive age.
Results. The examinees exhibited IgA ABtTG in the range 1 to 280 IU/ml, while 16 of them had elevated level - 50.2 ± 194 IU/ml, on the average. The controls had 0-10 IU/ml level of ABtTG, mean level 4.3±1.5 IU/ml. EGDS with duodenobiopsy was performed in 14 women. The examination of biopsies from small intestinal mucosa has detected pathohistological signs of celiac disease in 7 of 14 women. At the moment of the study two women with a history of spontaneous abortion were pregnant. Their ABtTG was 21.7 and 15.9 IU/mg, respectively, EGDS was not performed because of potential pregnancy complication but in view of possible celiac disease they received recommendations on aglutenic diet.
Conclusion. Incidence rate of GSCD in women with RD is 4,1%. Aglutenic diet in GSCD women with RD contributes to reproductive function recovery and normal outcome of pregnancy. Elevation of ABtTG titers in women with RD is an indication to histological examination of small intestinal mucosa to detect GSCD.
About the authors
Svetlana Vladimirovna Bykova
Email: svetfox@yandex.ru
Asfol'd Ivanovich Parfenov
Email: asfold@mail.ru
Nana Kartlosovna Tetruashvili
Email: tetrauly@mail.ru
Elena Anatol'evna Sabel'nikova
Raisa Borisovna Gudkova
L M Krums
Natal'ya Nikolaevna Vorob'eva
Ekaterina Aleksandrovna Repina
Irina Ivanovna Vityazeva
Galina Stefanovna Petukhova
S V Bykova
Central Research Institute of Gastroenterology, MoscowCentral Research Institute of Gastroenterology, Moscow
A I Parfenov
Central Research Institute of Gastroenterology, MoscowCentral Research Institute of Gastroenterology, Moscow
N K Tetruashvili
Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, MoscowAcad. V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Moscow
E A Sabelnikova
Central Research Institute of Gastroenterology, MoscowCentral Research Institute of Gastroenterology, Moscow
R B Gudkova
Central Research Institute of Gastroenterology, MoscowCentral Research Institute of Gastroenterology, Moscow
L M Krums
Central Research Institute of Gastroenterology, MoscowCentral Research Institute of Gastroenterology, Moscow
N N Vorobyeva
Central Research Institute of Gastroenterology, MoscowCentral Research Institute of Gastroenterology, Moscow
E A Repina
Research Center for Endocrinology, MoscowResearch Center for Endocrinology, Moscow
I N Vityazeva
Research Center for Endocrinology, MoscowResearch Center for Endocrinology, Moscow
G S Petukhova
Moscow Reproduction Center, MoscowMoscow Reproduction Center, Moscow
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