Email this article Efficacy of rifaximine in intestinal bacterial overgrowth syndrome in patients after cholecystectomy
- Authors: Mechetina T.A.1, Il'chenko A.A.1, Mechetina TA2, Ilchenko AA2
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Affiliations:
- Central Research Institute of Gastroenterology, Moscow
- Issue: Vol 83, No 12 (2011)
- Pages: 68-73
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30963
- ID: 30963
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Abstract
Aim. To define frequency of onset of small intestinal bacterial overgrowth syndrome (SIBOGS) in patients with postcholecystomy syndrome (PCS); to substantiate necessity of microflora correction and assess efficacy of rifaximine in the doses 800 and 1200 mg/day.
Material and methods. A breath hydrogen test (BHT) was made in 82 PCS patients. Rifaximine was given to 40 SIBOGS patients: 20 of them received the drug in a dose 800 mg/day and 20 - in a dose 1200 mg/day for 7 days. The efficacy was estimated by attenuation of the clinical symptoms and parameters of BHT.
Results. SIBOGS was detected in 73% of PCS patients. This was an indication for antibacterial treatment. Rifaximine in a dose 800 mg/day failed to attenuate pain and to eliminate dyspeptic syndromes in some patients, BHT in them was not normal. Administration of rifaximine in a dose 1200 mg/day normalized BHT in 90% patients and eliminated clinical symptoms in most of the patients. Conclusion. Rifaximine in a dose 1200 mg/day vs 800 mg/day in PCS patients with SIBOGS is more effective as it eliminates clinical symptoms and normalizes BHT.
Material and methods. A breath hydrogen test (BHT) was made in 82 PCS patients. Rifaximine was given to 40 SIBOGS patients: 20 of them received the drug in a dose 800 mg/day and 20 - in a dose 1200 mg/day for 7 days. The efficacy was estimated by attenuation of the clinical symptoms and parameters of BHT.
Results. SIBOGS was detected in 73% of PCS patients. This was an indication for antibacterial treatment. Rifaximine in a dose 800 mg/day failed to attenuate pain and to eliminate dyspeptic syndromes in some patients, BHT in them was not normal. Administration of rifaximine in a dose 1200 mg/day normalized BHT in 90% patients and eliminated clinical symptoms in most of the patients. Conclusion. Rifaximine in a dose 1200 mg/day vs 800 mg/day in PCS patients with SIBOGS is more effective as it eliminates clinical symptoms and normalizes BHT.
About the authors
Tat'yana Anatol'evna Mechetina
Email: tatyana22_82@mail.ru
Anatoliy Afanas'evich Il'chenko
T A Mechetina
Central Research Institute of Gastroenterology, MoscowCentral Research Institute of Gastroenterology, Moscow
A A Ilchenko
Central Research Institute of Gastroenterology, MoscowCentral Research Institute of Gastroenterology, Moscow
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