Thrombin-activated inhibitor of fibrinolysis and efficacy and safety of long-term warfarin treatment in patients with venous thromboembolic complications
- Authors: Vorob'eva N.M.1, Panchenko E.P.1, Dobrovol'skiy A.B.1, Titaeva E.V.1, Ermolina OV1, Balakhonova TV1, Khasanova Z.B.1, Postnov A.Y.1, Kirienko A.I.1, Vorobyeva NM2, Panchenko EP2, Dobrovolsky AB2, Titaeva EV2, Ermolina OV2, Balakhonova TV2, Khasanova ZB2, Postnov AY.2, Kirienko AI3
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Affiliations:
- Russian Research Cardiology Center, Moscow
- N. I. Pirogov Russian State Moscow University, Moscow
- Issue: Vol 83, No 12 (2011)
- Pages: 43-48
- Section: Editorial
- Submitted: 10.04.2020
- Published: 15.12.2011
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30947
- ID: 30947
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Abstract
Results. A TAFI level varied from 50 to 217% (median 106%, interquartile rage 90-133%). TAFI concentration positively correlated with fibrinogen and thromb size. The patients were divided into two groups depending on TAFI content: group 1 patients had low TAFI (under 25th percentile; < 90%); patients of group 2 had high TAFI (above 25th percentile; > 90%). Group 1 patients were characterized by less stable anticoagulation. This association did not depend on genetic characteristics which determine sensitivity to warfarin (CYP2C9 and VKORC1). Low TAFI was associated with reduced risk of DVT for 18 months and higher probability of complete lysis of the thrombi after 12 months of anticoagulant therapy compared to VTEC patients with high TAFI. No differences were found by TAFI level in patients with HC and without HC, but in HC patients low TAFI was associated with spontaneous hemorrhages and bleeding in therapeutic INR values.
Conclusion. The results of this pilot study evidence that a TAFI level can be one of the factors influencing efficacy and safety of long-term anticoagulant therapy in patients with VTEC on warfarin treatment.
About the authors
Natal'ya Mikhaylovna Vorob'eva
Email: natalyavorobjeva@mail.ru
Elizaveta Pavlovna Panchenko
Email: lizapanchenko@mail.ru
Anatoliy Borisovich Dobrovol'skiy
Email: abdobrovolsky@inbox.ru
Elena Vladimirovna Titaeva
Email: evlti@mail.ru
O V Ermolina
T V Balakhonova
Zukhra Bilyalovna Khasanova
Email: khasanova@mail.ru
Anton Yuvenal'evich Postnov
Email: anton-5@mail.ru
Aleksandr Ivanovich Kirienko
Email: phlebo-union@mtu-net.ru
N M Vorobyeva
Russian Research Cardiology Center, MoscowRussian Research Cardiology Center, Moscow
E P Panchenko
Russian Research Cardiology Center, MoscowRussian Research Cardiology Center, Moscow
A B Dobrovolsky
Russian Research Cardiology Center, MoscowRussian Research Cardiology Center, Moscow
E V Titaeva
Russian Research Cardiology Center, MoscowRussian Research Cardiology Center, Moscow
O V Ermolina
Russian Research Cardiology Center, MoscowRussian Research Cardiology Center, Moscow
T V Balakhonova
Russian Research Cardiology Center, MoscowRussian Research Cardiology Center, Moscow
Z B Khasanova
Russian Research Cardiology Center, MoscowRussian Research Cardiology Center, Moscow
A Yu Postnov
Russian Research Cardiology Center, MoscowRussian Research Cardiology Center, Moscow
A I Kirienko
N. I. Pirogov Russian State Moscow University, MoscowN. I. Pirogov Russian State Moscow University, Moscow
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