Calcium channels blocker felodipin: perspectives in the treatment of arterial hypertension and chronic cardiac failure with normal ejection fraction

Cite item

Full Text


The article is devoted to issues of clinical diagnosis and treatment of patients with chronic cardiac failure and normal ejection fraction (CCF-NEF). Original clinical trials of felodipin efficacy designed to be maximally close to every-day clinical practice in Russia included hypertensive patients with CCF-NEF. The results of these trials bring about the conclusion that felodipin not only maintain blood pressure at the target level but also improves diastolic function of the myocardium.

About the authors

Oksana Mikhaylovna Drapkina

Yaroslav Igorevich Ashikhmin

O M Drapkina

I. M. Sechenov First Moscow State Medical University, Moscow

I. M. Sechenov First Moscow State Medical University, Moscow

Ya I Ashikhmin

I. M. Sechenov First Moscow State Medical University, Moscow

I. M. Sechenov First Moscow State Medical University, Moscow


  1. Maeder M. T., Kaye D. M. Heart failure with normal left ventricular ejection fraction. J. Am. Coll. Cardiol. 2009; 53: 905- 918.
  2. Драпкина О. М., Ашихмин Я. И. Хроническая сердечная недостаточность с сохраненной фракцией выброса: патофизиология, диагностика, стратегии лечения. Кардиология 2009; 49 (9): 90-95.
  3. Боткин С. П. Курс клиники внутренних болезней. СПб.; 1899.
  4. Nakajima Y., Kane G. C., McCully R. B. et al. Left ventricular diastolic filling pressures during dobutamine stress echocardiography: relationship to symptoms and ischemia. J. Am. Soc. Echocardiogr. 2009; 22 (8): 947-953.
  5. Ланг Г. Ф. Гипертоническая болезнь. М.; 1950.
  6. Lam С. S. P., Roger V. L., Rodeheffer R. J. et al. Pulmonary hypertension in heart failure with preserved ejection fraction. J. Am. Coll. Cardiol. 2009; 53: 1119-1126.
  7. Harrison's principles of internal medicine. 7-th ed. New York; 2008.
  8. Siegenthaler's differential diagnosis in internal medicine. Thieme; 2007.
  9. Drapkina O. M., Smirnova V. N., Ashikhmin Y. I. Severe non-adherence to treatment phenomena in Russian patients with advanced atherosclerosis. In: 18-th European congress of psychiatry Accepted for publication.
  10. МакДермотт М. Т. Секреты эндокринологии. М.: Бином; 2001.
  11. Схиртладзе М. Р., Драпкина О. М. Оценка трофологического статуса у больных хронической сердечной недостаточностью. Рос. мед. вести 2009; 2: 44-52.
  12. Zipes A. et al. Braunwald's heart disease. 8-th ed. New York; 2007.
  13. Pasha S. M., Klok F. A., Snoep J. D. et al. Safety of excluding acute pulmonary embolism based on an unlikely clinical probability by the Wells rule and normal D-dimer concentration: A meta-analysis. Thromb. Res. 2009; 1: 1-10.
  14. Little W. C. Heart failure with a normal left ventricular ejection fraction: diastolic heart failure. Trans. Am. Clin. Climatol. Assoc. 2008; 19: 93-102.
  15. Paulus W. J., Carsten T., Sanderson J. E. et al. How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. Eur. Heart J. 2007; 28: 2539-2550.
  16. Lenzen M., Scholte op Reimer W., Boersma E. et al. Differences between patients with a preserved and a depressed left ventricular function: a report from the EuroHeart Failure Survey. Eur. Heart. J. 2004; 25: 1214-1220.
  17. Cleland J. G. F., Tendera M., Adamus J. et al. The perindopril in elderly people with chronic heart failure (PEP-CHF) study. Eur. Heart J. 2006; 27: 2338-2345.
  18. Aronow W., Kronzon I. Effect of enalapril on congestive heart failure treated with diuretics in elderly patients with prior myocardial infarction and normal left ventricular ejection fraction. Am. J. Cardiol. 1993; 71: 602-604.
  19. Carson P., Johnson G., Fletcher R. et al. Mild systolic dysfunction in heart failure: baseline characteristics, prognosis and response to therapy in the Vasodilatator in Heart Failure Trials (V-HeFT). J. Am. Coll. Cardiol. 1996; 27: 642-649.
  20. Yusuf S., Pfeffer M., Swedberg K. et al. Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved trial. Lancet 2003; 362: 777-781.
  21. Massie В. М., Carson Р. Е., McMurray J. J. et al. Irbesartan in patients with heart failure and preserved ejection fraction. N. Engl. J. Med. 2008; 359: 2456-2467.
  22. The Digitalis Investigation Group. The effect of digoxin on mortality and morbidity in patients with heart failure. N. Engl. J. Med. 1997; 336: 525-533.
  23. Flather M., Shibata M., Coats A. et al. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur. Heart J. 2005; 26: 215-225.
  24. Ghio S., Magrini G., Serio A. et al. Effect of nebivolol in elderly heart failure patients with or without systolic left ventricular dysfunction: results of the SENIORS echocardiographic substudy. Eur. Heart J. 2006; 27: 562-568.
  25. Smiseth O. A., Tendera M. Diastolic heart failure. London: Springer-Verlag; 2008.
  26. Bergstrom A., Andersson B., Edner M. et al. Carvedilol improves diastolic function in patients with diastolic heart failure. Circulation 2001; 104 (Suppl. II): II7.
  27. Bi X. P., Tan H. W., Xing S. S. et al. Felodipine downregulates serum interleukin-18 levels in rats with fructose-induced metabolic syndrome. Endocrinol. Invest. 2009; 32 (4): 303-307.
  28. Tan H. W., Xing S. S., Bi X. P. et al. Felodipine attenuates vascular inflammation in a fructose-induced rat model of metabolic syndrome via the inhibition of NF-kappaB activation. Acta Pharmacol. Sin. 2008; 29 (9): 1051-1059.
  29. Xing S. S., Tan H. W., Bi X. P. et al. Felodipine reduces cardiac expression of IL-18 and perivascular fibrosis in fructose-fed rats. Mol. Med. 2008; 14 (7-8): 395-402.
  30. Yao R., Cheng X., Liao Y. H. et al. Molecular mechanisms of felodipine suppressing atherosclerosis in high-cholesterol-diet apolipoprotein E-knockout mice. J. Cardiovasc. Pharmacol. 2008; 51 (2): 188-195.
  31. Relaxin 2008. Proceedings of the Relaxin and Related Peptides 5th International Conference, May 18-23, 2008, Maui, Hawaii, USA. Ann. N. Y. Acad. Sci. 2009; 1160.

Copyright (c) 2011 Drapkina O.M., Ashikhmin Y.I., Drapkina O.M., Ashikhmin Y.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Address of the Editorial Office:

  • Novij Zykovskij proezd, 3, 40, Moscow, 125167

Correspondence address:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Managing Editor:


© 2018-2021 "Consilium Medicum" Publishing house

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies