Immunological aspects of HCV/HIV coinfection


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Aim. To evaluate effects of HCV/HIV coinfection on blood lymphocyte phenotype including cells CD56+.
Material and methods. We studied standard immunogram, subpopulational composition and functional activity of blood cells CD56+ in 67 patients with verified diagnosis of HIV infection and virus hepatitis C.
Results. We discovered some pathogenetically sound indices of immune status in patients with HCV/ HIV coinfection. Some of the immune shifts detected changed in response to intake of narcotic drugs, antiretroviral treatment, hepatic cirrhosis, pneumonia.
Conclusion. Parameters of subpopulational composition and functional activity of cells CD56+ in the blood of patients with HCV/HIV coinfection elucidate some unknown features of the above infectious process which should be considered in this coinfection treatment and prophylaxis.

About the authors

Nikolay Dmitrievich Yushchuk

Irina Viktorovna Shestakova

Email: shes.irin@mtu-net.ru

Irina Petrovna Balmasova

Email: immunolab@rnail.ru

Mariya Vladimirovna Vysheslavtseva

Email: yyshla@gmail.com

Evgeniya Vasil'evna Shmeleva

Email: sh_mel@rambler.ru

N D Yuschuk

Moscow State Medico-Stomatological University, Moscow

Moscow State Medico-Stomatological University, Moscow

I V Shestakova

Moscow State Medico-Stomatological University, Moscow

Moscow State Medico-Stomatological University, Moscow

I P Balmasova

Laboratory of pathogenesis and methods of infectious diseases treatment of MSMSU, Moscow

Laboratory of pathogenesis and methods of infectious diseases treatment of MSMSU, Moscow

M V Vysheslavtseva

Moscow State Medico-Stomatological University, Moscow

Moscow State Medico-Stomatological University, Moscow

E V Shmeleva

Laboratory of pathogenesis and methods of infectious diseases treatment of MSMSU, Moscow

Laboratory of pathogenesis and methods of infectious diseases treatment of MSMSU, Moscow

References

  1. Ananda S., Shaohua Z., Fan Y., Liang L. HIV-negative drug addict diagnosed with AIDS and tuberculosis at autopsy: A case report and brief review of literature. J. Forens. Leg. Med. 2011; 18 (3): 136-138.
  2. Онищенко Г. Г. Национальный доклад Российской Федерации о ходе выполнения Декларации о приверженности делу борьбы с ВИЧ/СПИДом. принятой в ходе 26-й специальной сессии Генеральной ассамблеи ООН, июнь 2001 г. М.; 2010.
  3. Hirsch J. D., Gonzales M., Rosenquist A. et al. Antiretroviral therapy adherence, medication use and health care costs during 3 years of a community pharmacy medication therapy management program for medical beneficiaries with HIV/ AIDS. J. Manag. Care Pharm. 2011; 17 (3): 213-223.
  4. El-Sadr W. M., Affrunti M., Gamble Т., Zerbe A. Antiretroviral therapy: a promising HIV prevention strategy? J. Acquir Immune Defic. Syndr. 2010; 55 (2): 116-121.
  5. Zoller H., Vogel W. Nanomedicines in the treatment of patients with hepatitis С co-infected with HIV-focus on pegylated interferon-alpha. Int. J. Nanomed. 2006: 1 (4): 399-409.
  6. Alter M. J. Epidemiology of viral hepatitis and HIV co-infection. J. Hepatol. 2006: 44 (1): 6-9.
  7. Kumar R., Singla V., Kacharya S. Impact and management of hepatitis В and hepatitis С virus co-infection in HIV patients. Trop. Gastroenterol. 2008; 29 (3): 136-147.
  8. Matthews G. V., Dore G. J. HIV and hepatitis С coinfection. J. Gastroenterol. Hepatol. 2008; 23 (7, Pt 1): 1000-1008.
  9. Ruiz-Sancho A., Soriano V. HIV and HCV coinfection. Enferm. Infecc. Microbiol. Clin. 2006; 24 (5): 335-345.
  10. Soriano V., Martin-Carbonero L., Maida I. et al. New paradigms in the management of HIV and hepatitis С virus coinfection. Curr. Opin. Infect. Dis. 2005; 18 (6): 550-560.
  11. Rohrbach J., Robinson N., Harcourt G. et al. Cellular immune responses to HCV core increase and HCV RNA levels decrease during successful antiretroviral therapy. Gut 2010; 59 (9): 1252-1258.
  12. Kovacs A., Karim R., Mack W. J. et al. Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis С virus. J. Infect. Dis. 2010; 201 (6): 823-834.
  13. Gonzalez V. D., Landay A. L., Sandberg J. K. Innate immunity and chronic immune activation in HCV/HIV-1 co-infection. Clin. Immunol. 2010; 135 (1): 12-25.
  14. Belmonte L., Parodi C., Bare P. et al. The role of dendritic cells in the infection by HIV and HCV. Medicina (B. Aires) 2007; 67 (1): 63-70.
  15. Lin A. W., Gonzalez S. A., Cunningham-Rundles S. et al. CD56+dim and CD56+bright cell activation and apoptosis in hepatitis С virus infection. Clin. Exp. Immunol. 2004; 137 (2): 408-416.
  16. Сепиашвили Р. И., Балмасова И. П. Физиология естественных киллеров. М.: Медицина-Здоровье; 2005.
  17. Altfeld M., Fadda L., Frleta D., Bhardwaj N. DCs and NK cells: critical effectors in the immune response to HIV-1. Nature Rev. Immunol. 2011: 11 (3): 176-186.
  18. Tudor D., Bomsel M. The broadly neutralizing HIV-1 IgG 2F5 elicits gp41-specific antibody-dependent cell cytotoxicity in a FcγRI-dcpendcnt manner. AIDS 2011: 25 (6): 751-759.
  19. Балмасова И. П., Ющук Н. Д., Знойко О. О. и др. Соотношение субпопуляций ЕК/ЕКТ как прогностический критерий хронического гепатита С. Аллергол. и иммунол. 2009; 10 (3): 340-343.
  20. Малова Е. С., Ющук Н. Д., Балмасова И. П., Шмелева Е. В. CD56+-лимфоциты и иммунопатогенез хронического гепатита С. Иммунология 2010; 31 (6): 310-315.
  21. Oliviero В., Varchetta S., Paudice E. et al. Natural killer cell functional dichotomy in chronic hepatitis В and chronic hepatitis С virus infections. Gastroenterology 2009; 137 (3): 1151- 1160.
  22. Kuylenstierna C., Snyder-Cappione J. E., Loo С. Р. et al. NK cells and CD1d-restricted NKT cells respond in different ways with divergent kinetics to IL-2 treatment in primary HIV-1 inlection. Scand. J. Immunol. 2011; 73 (2): 141-146.
  23. Vasan S., Tsuji M. A double-edged sword: the role of NKT cells in malaria and HIV infection and immunity. Semin. Immunol. 2010; 22 (2): 87-96.
  24. Kanto Т., Hayashi N. Innate immunity in hepatitis С virus infection: Interplay among dendritic cells, natural killer cells and natural killer T cells. Hepatol. Res. 2007; 37 (3): 319-326.

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