Modern conceptions of an uric acid role in development of essential hypertension


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Abstract

The article deals with current studies on the role of uric acid (UA) in development of cardiovascular diseases. The results of large prospective trials are presented which have revealed a pathogenetic role of UA in development of essential hypertension. Clinical trials demonstrated elevated concentrations of UA in hypertensive patients. Experimental evidence suggests UA involvement in the processes of nonspecific inflammation, oxidant stress, endothelial dysfunction. It is shown that elevated UA levels in blood serum lead to affection of target organs.

About the authors

Ol'ga Vasil'evna Polovitkina

Elena Vladimirovna Oshchepkova

Viktor Aleksandrovich Dmitriev

Email: vicdmi@mail.ru

Vladimir Nikolaevich Titov

O V Polovitkina

Russian Research Cardiological Center, Moscow

Russian Research Cardiological Center, Moscow

E V Oschepkova

Russian Research Cardiological Center, Moscow

Russian Research Cardiological Center, Moscow

V A Dmitriev

Russian Research Cardiological Center, Moscow

Russian Research Cardiological Center, Moscow

V N Titov

Russian Research Cardiological Center, Moscow

Russian Research Cardiological Center, Moscow

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