High arterial rigidity is a significant but not obligatory factor of arterial hypertension in persons over 60 years of age
- Authors: Boytsov S.A.1, Rogoza A.N.1, Kanishcheva E.M.1, Luk'yanov M.M.1, Boitsov SA2, Rogoza AN2, Kanischeva EM2, Lukianov MM2
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Affiliations:
- Russian Cardiological Research Center, Moscow
- Issue: Vol 83, No 9 (2011)
- Pages: 5-9
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30883
- ID: 30883
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Abstract
Material and methods. Volume sphygmography (VS) was made in 153 patients aged 60-86 years: 96 patients with untreated AH of degree 1-3 (40 males aged 71.0±7.6 years) and 57 normotensive subjects without cardiovascular symptoms (31 males aged 66.6±6.2 years). VS measured ankle-shoulder velocity of the pulse wave (PWVas) and cardiac-ankle vascular index (CAVI). PWVas > M+STD and CAVI > M+2STD (STD is deviation from mean value) were considered above normal for the age.
Results. Hypertensive patients had significantly higher arterial rigidity than normotensives (PWVas 17.8±3.0 and 15.6 ± 2.3 m/s, respectively, p = 0.00001); CAVI - 9.7±2.1 and 8.6±1.1, respectively, p = 0.0003). Arterial rigidity in hypertensive patients occurred significantly more frequently than in normotensive subjects: by PWVas in 46 and 25% cases (p = 0.01), by CAVI - in 41 and 5% cases (p < 0.0001), respectively. It is essential that arterial rigidity was not increased in 54% hypertensive patients by PWVas and in 75% by CAVI.
Conclusion. PWVas and CAVI were higher in elderly hypertensives than in elderly normotensives but elevated arterial rigidity was not obligatory in hypertensives while 25% elderly normotensives had it. Thus, elevated arterial rigidity is an essential but not obligatory mechanism of AH development in the elderly.
About the authors
Sergey Anatol'evich Boytsov
Email: prof-boytsov@mail.ru
Anatoliy Nikolaevich Rogoza
Elena Mikhaylovna Kanishcheva
Email: louri@mail.ru
Mikhail Mikhaylovich Luk'yanov
S A Boitsov
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
A N Rogoza
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
E M Kanischeva
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
M M Lukianov
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
References
- Liao D., Amett D. K., Tyroler H. A. et al. Arterial Stiffness and the development of hypertension. The ARIC Study. Hypertension 1999; 34: 201-206.
- Franklin S. S. Predominance of isolated systolic hypertension among middle-aged and elderly US hypertensives. Analysis based on National Health and Nutrition Examination Survey (NHANES III). Hypertension 2001; 37: 869-874.
- Benetos A., Adamopoulos C., Bureau J. M. et al. Stiffness in normotensive subjects and in treated hypertensive subjects over a 6-year period. Circulation 2002; 105: 1202-1207.
- Laurent S., Cockcroft J., Van Bortel L. et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006; 27: 2588-2605.
- Mitchell G. F., Lacourciere Y., Ouellet J. P. et al. Determinants of elevated pulse pressure in middle-aged and older subjects with uncomplicated systolic hypertension: the role of proximal aortic diameter and the aortic pressure-flow relationship. Circulation 2003; 108: 1592-1598.
- Vasan R. S., Larson M. G., Levy D. Determinants of echocardiographic aortic root size: the Framingham Heart Study. Circulation 1995; 91: 734-740.
- O'Rourke M. F., Nichols W. W. Aortic diameter, aortic stiffness, and wave reflection increase with age and isolated systolic hypertension. Hypertension 2005; 45 (2): 652-658.
- Hayoz D., Rutschmann B., Perret F. et al. Conduit artery compliance and distensibility are not necessarily reduced in hypertension. Hypertension 1992; 20: 1-6.
- Милягин В. А., Милягина И. В. и др. Новый автоматизированный метод определения скорости распространения пульсовой волны. Функцион. диагн., 2004; 1: 33-39.
- Матросова И. Б., Борисычева Н. В., Олейников В. Э. Сердечно-лодыжечный сосудистый индекс (CAVI) - новый неинвазивный параметр оценки сосудистой ригидности. Изв. высш. учеб. заведений. Поволж. регион. Мед. науки 2009; 2: 90-101.