Nine-year experience in the treatment of patients with diffuse large B-cell lymphosarcoma

Aminat Umaraskhabovna Magomedova; Магомедова Аминат Умарасхабовна; S K Kravchenko; Кравченко С К; A M Kremenetskaya; Кременецкая A M; E A Zvonkov; Звонков Е А; E A Baryakh; Барях Е А; Ya K Mangasarova; Мангасарова Я К; I B Kaplanskaya; Капланская И Б; R S Samoylova; Самойлова Р С; I A Vorob'ev; Воробьев И А; T N Obukhova; Обухова Т Н; S R Karagyulyan; Карагюлян С Р; E M Shulutko; Шулутко Е М; G M Galstyan; Галстян Г М; D S Mar'in; Марьин Д С; N G Gabeeva; Габеева Н Г; A I Vorob'ev; Воробьев А И; A U Magomedova; Magomedova A U; S K Kravchenko; Kravchenko S K; A M Kremenetskaya; Kremenetskaya A M; E A Zvonkov; Zvonkov E A; E A Baryakh; Baryakh E A; Ya K Mangasarova; Mangasarova Ya K; I B Kaplanskaya; Kaplanskaya I B; R S Samoilova; Samoilova R S; I A Vorobiev; Vorobiev I A; T N Obukhova; Obukhova T N; S R Karagyulyan; Karagyulyan S R; E M Shulutko; Shulutko E M; G M Galstyan; Galstyan G M; D S Maryin; Maryin D S; N G Gabeeva; Gabeeva N G; A I Vorobiev; Vorobiev A I

Nine-year experience in the treatment of patients with diffuse large B-cell lymphosarcoma

Authors: Magomedova A.U.¹, Kravchenko SK¹, Kremenetskaya AM¹, Zvonkov EA¹, Baryakh EA¹, Mangasarova Y.K¹, Kaplanskaya IB¹, Samoylova RS¹, Vorob'ev IA¹, Obukhova TN¹, Karagyulyan SR¹, Shulutko EM¹, Galstyan GM¹, Mar'in DS¹, Gabeeva NG¹, Vorob'ev AI¹, Magomedova AU², Kravchenko SK², Kremenetskaya AM², Zvonkov EA², Baryakh EA², Mangasarova Y.K², Kaplanskaya IB², Samoilova RS², Vorobiev IA², Obukhova TN², Karagyulyan SR², Shulutko EM², Galstyan GM², Maryin DS², Gabeeva NG², Vorobiev AI²
Affiliations:
2. Hematological Research Center, Moscow
Issue: Vol 83, No 7 (2011)
Pages: 5-10
Section: Editorial
URL: https://ter-arkhiv.ru/0040-3660/article/view/30846
ID: 30846

Cite item

Abstract

Aim. To ascertain indications to standard (CHOP-21/R-CHOP-21) and intensive (mNHL-BFM-90) treatment in patients with diffuse large B-cell lymphosarcoma (DLBCL) with involvement of lymphoid organs.
Material and methods. The trial, performed from January 2002 to December 2010, enrolled 139 DLBCL patients with affected lymph nodes (LN), tonsils, spleen, bone marrow (BM). The diagnosis was made according to WHO criteria. The patients were examined according to the protocol of lymphoproliferative diseases. Biopsy material from all 139 patients was studied immunohistochemically on paraffin blocks (LN, tonsils, spleen, BM) using a wide panel of antibodies. The same examinations of BM were made in all 18 cases of BM involvement. Cytogenetic examination was performed in 106 patients: 48 standard cytogenetic tests, 139 - FISH for t (14;18) as well as rearrangement of locus 3q27. Patients with a poor prognosis (n = 86, 61.8%) received intensive therapy according to mNHL-BFM-90 program. The signs of a poor prognosis were the following: massive tumor (tumor size more than 7.5 cm), invasion into the adjacent organs or tissues, stage III-IV disease by Enn-Erbor, high concentration of LDG. Patients without a poor prognosis (n = 53, 38.2%) received standard treatment CHOP-21 (n = 28) or R-CHOP-21 (n = 25).
Results. A complete remission without recurrences was achieved in all 53 patients without signs of unfavourable prognosis (100%). Overall 5-year survival was 96%, 2 patients died in remission of other causes. Of 86 patients with a poor prognosis a complete remission was achieved in 64 (74.4%) patients. Overall and recurrence-free 5-year survival was 65 and 86%, respectively.
Conclusion. Standard treatment provided long-term complete remission in all the patients without poor prognosis. Intensive (mNHL-BFM-90) treatment produced the best results in generalized lesion without BM involvement. Overall 5-year survival was 84% in these patients and 12% in patients with BM involvement.

Keywords

R-CHOP-21, mNHL-BFM-90, diffuse large B-cell lymphoma, CHOP-21, R-CHOP-21, mNHL-BFM-90

References

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Nine-year experience in the treatment of patients with diffuse large B-cell lymphosarcoma

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