Email this article Arterial stiffness in patients with systemic sclerosis
- Authors: Karoli N.A.1, Rebrov A.P.1, Karoli NA2, Rebrov AP2
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Affiliations:
- V.I. Razumovsky State Medical University, Saratov
- Issue: Vol 83, No 5 (2011)
- Pages: 38-41
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30842
- ID: 30842
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Abstract
Aim. To study arterial stiffness (AS) in patients with systemic sclerosis (SS).
Material and methods. A total of 38 SS patients (36 females and 2 males over 40 years of age) entered the study. They met the following criteria: clinical symptoms of coronary heart disease, atherosclerosis of peripheral vessels, other severe chronic diseases in exacerbation. The control group consisted of 28 healthy matched volunteers. AS was measured with Tensioclinic (Tensiomed, Hungary) arteriograph which demonstrated changes in arterial bed in SS patients.
Results. Arterial overrigidity and accelerated reflection of the pulse wave have a strong impact on elevation of the central arterial pressure. High blood pressure in the ascending aorta overloads the left ventricle and promotes development of its hypertrophy, deteriorates diastolic relaxation and, finally, damages pump function of the heart. Moreover, chronic elevation of the central arterial pressure is the end component in formation of the vicious circle of a further increase of the cardiovascular risk and the marker of target organ affection.
Conclusion. Increased vascular stiffness in SS patients suggests increased cardiovascular risk in these patients. Prospective studies of this risk are needed.
Material and methods. A total of 38 SS patients (36 females and 2 males over 40 years of age) entered the study. They met the following criteria: clinical symptoms of coronary heart disease, atherosclerosis of peripheral vessels, other severe chronic diseases in exacerbation. The control group consisted of 28 healthy matched volunteers. AS was measured with Tensioclinic (Tensiomed, Hungary) arteriograph which demonstrated changes in arterial bed in SS patients.
Results. Arterial overrigidity and accelerated reflection of the pulse wave have a strong impact on elevation of the central arterial pressure. High blood pressure in the ascending aorta overloads the left ventricle and promotes development of its hypertrophy, deteriorates diastolic relaxation and, finally, damages pump function of the heart. Moreover, chronic elevation of the central arterial pressure is the end component in formation of the vicious circle of a further increase of the cardiovascular risk and the marker of target organ affection.
Conclusion. Increased vascular stiffness in SS patients suggests increased cardiovascular risk in these patients. Prospective studies of this risk are needed.
Keywords
About the authors
Nina Anatol'evna Karoli
Andrey Petrovich Rebrov
Email: rebrov@sgu.ru
N A Karoli
V.I. Razumovsky State Medical University, SaratovV.I. Razumovsky State Medical University, Saratov
A P Rebrov
V.I. Razumovsky State Medical University, SaratovV.I. Razumovsky State Medical University, Saratov
References
- Arnett D. K., Evans G. W., Riley W. A. Arterial stiffness: a new cardiovascular risk factor? Am. J. Epidemiol. 1994; 140: 669- 682.
- Laurent S., Cockcroft J., Van Bortel L. et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur. Heart J. 2006; 27: 2588-2605.
- Орлова Я. А., Агеев Ф. Т. Жесткость артерий как интегральный показатель сердечно-сосудистого риска: физиология, методы оценки и медикаментозной коррекции. Сердце 2006; 5 (2): 65-69.
- Nürnberger J., Keflioglu-Scheibera A., Opazo Saezb A. M. et al. Augmentation index is associated with cardiovascular risk. J. Hypertens. 2002; 20: 2407-2414.
- Алекперов Р. Т., Вышлова М. А., Балабанова Р. М. и др. Нарушения реологических свойств крови при системной склеродермии. Тер. арх. 2002; 5: 43-47.
- Hebbar M., Peyrat J.-P., Hornez L. et al. Increased concentrations of the circulating angiogenesis inhibitor endostatin in patients with systemic sclerosis. Arthr. and Rheum. 2000; 43: 889-893.
- Sheja A., Eskilsson J., Akesson A. et al. Inverse relation between plasma concentration of von Willebrand factor and CrEDTA clearance in systemic sclerosis. J. Rheumatol. 1994; 21(4): 639-642.
- Hettema M. E., Bootsma H., Kallenberg C. G. M. Macrovascular disease and atherosclerosis in SSc. Rheumatology 2008; 47: 578-583.
- Tsifetaki N., Georgiadis A. N., Alamanos U. et al. Subclinical atherosclerosis in scleroderma patients. Scand. J. Rheumathol. 2010; 39 (4): 326-329.
- Ребров А. П., Никитина Н. М., Кароли Н. А. и др. Жесткость артерий в зависимости от наличия факторов риска сердечно-сосудистых заболеваний. Тер. арх. 2009; 3: 54- 58.
- Кароли Н. А., Орлова Е. Е., Ребров А. П. Эндотелиальная дисфункция у больных системной склеродермией. Клин. мед. 2006; 7: 28-32.
- Cypiene A., Laucevicius F., Vemalis D. et al. The impact of systemic sclerosis on arterial wall stiffness parameters and endothelial function. Clin. Rheum. 2008; 27(12): 1517-1522.
- Timar O., Soltesz P., Szamosi S. et al. Increased arterial stiffness as the marker of vascular involvement in systemic sclerosis. J. Rheumatol. 2008; 35(7): 1329-1333.
- Гельцер Б. И., Бродская Т. А., Невзорова В. А., Моткина Е. В. Оценка центрального артериального давления у больных бронхиальной астмой. Пульмонология 2008; 3: 15-19.
- Moyssakis I., Gialafos E., Vassiliou V. et al. Aortic stiffness in systemic sclerosis is increased independently of the extent of skin involvement. Rheumatology 2004; 44(2): 251-254.
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