New aspects of using dihydropyridine calcium antagonists during coronary bypass surgery


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Abstract

Aim. To study the contractile properties of the human radial artery (RA) and to provide a comparative clinical assessment of the results of autoarterial coronary bypass surgery (AACBS) using calcium antagonists (CA).
Materials and methods. Human RA smooth muscle samples (n = 49) taken at AACBS were experimentally studied. Mechanography was used to record the contractile responses of isolated smooth muscle samples to the contractile properties of a RA segment exposed to the liquid vasodilators nifedipine, papaverine, and sodium nitroprusside. The study enrolled 106 patients who had undergone surgical revascularization applying 2 autoarteries or more. Dihydropyridine CAs, such as adulat, norvask, and felodip, were administered by the developed protocol.
Results. Adalat experimentally showed a pronounced dose-dependence of vasodilation and long-term aftereffects, which allows the CA to be regarded as the most attractive agent for the intraoperative preparation of an autoarterial shunt.
Conclusion. The systemic use of a dihydropyridine CA in a clinical trial could reduce the incidence of early autoarterial conduit dysfunction and improve prognosis in the patients.

About the authors

Yuriy Yur'evich Vecherskiy

Sergey Leonidovich Andreev

Email: anselen@rambler.ru

Boris Yur'evich Murashev

Yu Yu Vechersky

Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences

Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences

S L Andreyev

Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences

Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences

B Yu Murashev

Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences

Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences

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Copyright (c) 2010 Vecherskiy Y.Y., Andreev S.L., Murashev B.Y., Vechersky Y.Y., Andreyev S.L., Murashev B.Y.

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