New aspects of using dihydropyridine calcium antagonists during coronary bypass surgery

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Aim. To study the contractile properties of the human radial artery (RA) and to provide a comparative clinical assessment of the results of autoarterial coronary bypass surgery (AACBS) using calcium antagonists (CA).
Materials and methods. Human RA smooth muscle samples (n = 49) taken at AACBS were experimentally studied. Mechanography was used to record the contractile responses of isolated smooth muscle samples to the contractile properties of a RA segment exposed to the liquid vasodilators nifedipine, papaverine, and sodium nitroprusside. The study enrolled 106 patients who had undergone surgical revascularization applying 2 autoarteries or more. Dihydropyridine CAs, such as adulat, norvask, and felodip, were administered by the developed protocol.
Results. Adalat experimentally showed a pronounced dose-dependence of vasodilation and long-term aftereffects, which allows the CA to be regarded as the most attractive agent for the intraoperative preparation of an autoarterial shunt.
Conclusion. The systemic use of a dihydropyridine CA in a clinical trial could reduce the incidence of early autoarterial conduit dysfunction and improve prognosis in the patients.

About the authors

Yuriy Yur'evich Vecherskiy

Sergey Leonidovich Andreev


Boris Yur'evich Murashev

Yu Yu Vechersky

Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences

Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences

S L Andreyev

Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences

Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences

B Yu Murashev

Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences

Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences


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