Metabolic syndrome and insulin resistance in patients with chronic hepatitis C


Aim. To estimate the incidence and clinical value of metabolic syndrome, insulin resistance, and steatosis in patients with chronic hepatitis C (CHC) caused by its virus genotype 1.
Subjects and methods. One hundred and fourteen patients (67 men and 47 women; mean age 44.9±13.3 years) were examined.
Results. There were high incidence rates of metabolic syndrome (47.2%) and insulin resistance (50%), in the genesis of which the host-virus interaction is discussed. There was an independent correlation of the insulin resistance and elevated leptin levels with abdominal obesity and hepatic steatosis; however, these indicators did not correlate with the stage of fibrosis. At the same time hepatic steatosis (found in 38% of the patients) and its degree correlated with the stage of fibrosis. Thirty-four of 66 (54.5%) patients receiving antiviral therapy achieved a stable virological response.
Conclusion. Obesity, hyperglycemia, and significant insulin resistance along with the stage of hepatic cirrhosis are independent cofactors that determine no treatment response.

About the authors

Zhazira Zhanbulatovna Bayzhanova


Tat'yana Mikhaylovna Ignatova


Tat'yana Petrovna Nekrasova


Zh Zh Baizhanova

T M Ignatova

T P Nekrasova


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