Mini-invasive methods for diagnosis of diffuse interstitial lung disease

Cite item

Full Text


The paper specifies a place of various invasive diagnostic methods in suspected diffuse interstitial lung disease. It considers the problems associated with transbronchial, video-assisted thoracoscopic, and open biopsy of lung tissue and intrathoracic lymph nodes in this pathology and analyzes the informative value and safety of these methods, as well as indications for and contraindications to their use.

About the authors

Stanislav Anatol'evich Terpigorev


S A Terpigorev

M. F. Vladimirovsky Moscow Regional Research Clinical Institute

M. F. Vladimirovsky Moscow Regional Research Clinical Institute


  1. Fan L. L., Kozinetz C. A., Wojtczak H. A. Diagnostic value of trasbronchial, thoracoscopic, and open lung biopsy in immunocompetent children with chronic interstitial lung disease. J. Pediatr. 1997; 131: 565-569.
  2. Rothenberg S. S. Thoracoscopic lung resection in children. J. Pediatr. Surg. 2000; 35: 271-274.
  3. Rothenberg S. S. Thoracoscopy in infants and children. Semin. Pediatr. Surg. 1998; 7: 194-201.
  4. Kirschner P. A. Cervical mediastinoscopy. Chest Surg. Clin. N. Am. 1996; 6: 1-20.
  5. Annema J. T., Veselic M., Rabe K. F. Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of sarcoidosis. Eur. Respir. J. 2005; 25: 405-409.
  6. Webster A. D. Humoral immunodeficiency and the lung. Eur. Respir. Mon. 2006; 34: 220-233.
  7. British Thoracic Society. The diagnosis, assessment and treatment of diffuse parenhymal lung disease in adults. Thorax 1999; 54: i1-i21.
  8. Andersen H. A. Transbronchial lung biopsy for diffuse pulmonary disease. Results in 939 patients. Chest 1978; 73: 734- 736.
  9. Ensminger S. A., Prakash U. B. Is bronchoscopic lung biopsy helpful in the management of patients with diffuse lung disease? Eur. Respir. J. 2006; 28: 1081-1084.
  10. Prakash U. B. Bronchoscopy. In: Mason R. J., Broaddus V. C., Murray J. F., Nadel J. A., eds. Murray and Nadel's textbook respiratory medicine. 4-th ed. Philadelphia: Elsevier Saunders; 2005. 1617-1650.
  11. Popovich J. Jr., Kvale P. A., Eichenhorn M. S. et al. Diagnostic accuracy of multiple biopsies from flexible fiberoptic bronchoscopy. Am. Rev. Respir. Dis. 1982; 125: 521-523.
  12. Descombes E., Gardiol D., Leuenberger P. H. Transbronchial lung biopsy: an analysis of 530 cases with reference to the number of samples. Monaldi Arch. Chest Dis. 1997; 52: 324- 329.
  13. Meyer K. C. The role of bronchoalveolar lavage in interstitial lung disease. Clin. Chest Med. 2004; 25: 637-649.
  14. Klech H., Pohl W. Technical recommendations and guideline for broncho-alveolar lavage (BAL). Report of the European Society of Pnemonology Task Group on BAL. Eur. Respir. J. 1989; 2: 561-568.
  15. Niklinski J., Chyczewska E., Furman M. et al. Uscfulness of a multiple biomarker assay in bronchoalveolar lavage (BAL) and serum for the diagnosis of small cell lung cancer. Neoplasma 1993; 40: 305-308.
  16. Koontz C. H., Joyner L. R., Nelson R. A. Transbronchial lung biopsy via the fiberoptic bronchoscope in sarcoidosis. Ann. Intern. Med. 1976; 85: 64-66.
  17. Roette R., Byrd B., Hafermann D. Transbronchoscopic lung biopsy in sarcoidosis. Optimal number and sites for diagnosis. Chest 1980; 77: 400-402.
  18. Flint A., Martinez F., Young M. Influence of sample number and biopsy site on the histologic diagnosis of diffuse lung disease. Ann. Thorac. Surg. 1995; 60: 1605-1607.
  19. Vansteenkiste J., Verbeken E., Thomeer M. Medical thoracoscopic lung biopsy in interstitial lung disease: a prospective study of biopsy quality. Eur. Respir. J. 1999; 14: 585-590.
  20. Allen M., Champ De C., Jones D. et al. Video-assisted thoracic surgical procedures: the Mayo experience. Mayo Clin. Proc. 1996; 71: 351-359.
  21. Al-Kattan K. Thoracoscopic surgery: indications and outcome. Ann. Saudi Med. 2000; 20: 119-121.
  22. Shennib H. A., Landreneau R. J., Nulder D. S., Mack M. Video-assisted thoracoscopic wedge resection of T1 lung cancer in high-risk patients. Ann. Surg. 1993; 218: 555-560.
  23. Halkos M. E., Gal A. A., Kerendi F. et al. Role of thoracic surgeons in the diagnosis of idiopathic interstitial lung disease. Ann. Thorac. Surg. 2005; 79: 2172-2179.
  24. Ayed A. K. Video-assisted thoracoscopic lung biopsy in the diagnosis of diffuse interstitial lung disease. A prospective study. J. Cardiovasc. Surg. (Torino) 2003; 44: 115-118.
  25. Ayed A. K., Raghunathan R. Thoracoscopy versus open lung biopsy in the diagnosis of interstitial lung disease: a randomized controlled trial. J. Roy. Coll. Surg. Edinb. 2000; 45: 159-163.
  26. Koizumi K., Haraguchi S., Hirata T. et al. Thoracoscopic surgery in children. J. Nippon Med. Sch. 2005; 72: 34-43.
  27. Buchanan D. R., Neville E. Thoracoscopy for physicians. A practical guide. London: Arnold; 2004.
  28. Riantawan P., Koanantakool T., Chotivatanapong T. Video thoracoscopic lung biopsy in diffuse interstitial lung diseases. J. Med. Assoc. Thailand 1998; 81: 688-692.
  29. Du Bois R., King T. Challenges in pulmonary fibrosis. The NSIP/UIP debate. Thorax 2007; 62: 1008-1012.
  30. Colby T. V. Pathologic aspects of bronchiolitis obliterans organizing pneumonia. Chest 1992; 102: 38-43.
  31. Tiitto L., Heiskanen U., Bloigu R. et al. Thoracoscopic lung biopsy is a safe procedure in diagnosing usual interstitial pneumonia. Chest 2005; 128: 2375-2380.
  32. Zaraca F., Ebner H. Video-assisted thoracoscopic biopsy in the diagnosis of idiopathic interstitial lung disease. Chir. Ital. 2006; 58: 569-576.
  33. Ferson P. F., Landreneau R. J., Dowling R. D. et al. Comparison of open versus thoracoscopic lung biopsy for diffuse infiltrative pulmonary disease. Thorac. Cardiovasc. Surg. 1993; 106: 194-199.
  34. Qureshi R. A., Soorae A. A. Efficacy of thoracoscopic lung biopsy in interstitial lung diseases: comparison with open lung biopsy. J. Coll. Physicians Surg. Pak. 2003; 13: 600-603.
  35. Carnochan F. M., Walker W. S., Cameron E. W. Efficacy of video assisted thoracoscopic lung biopsy: an historical comparison with open lung biopsy. Thorax 1994; 49: 361-363.
  36. Atkins B., Harpole D., Mangum J. et al. Pulmonary segmentectomy by thoracotomy or thoracoscopy: reduced hospital length of stay with a minimally-invasive approach. Ann. Thorac. Surg. 2007; 84: 1107-1113.
  37. Miller J. D., Urschel J. D., Cox G. et al. A randomized, controlled trial comparing thoracoscopy and limited thoracotomy for lung biopsy in interstitial lung disease. Ann. Thorac. Surg. 2000; 70: 647-650.
  38. Martin T., Larraga R., Badorrey I. Videothoracoscopy versus thoracotomy in the diagnosis of diffuse interstitial disease. Arch. Bronconeumol. 1997; 33: 341-345.
  39. Landreneau R., Hazelrigg S., Mack M. et al. Postoperative pain-related morbidity: video-assisted thoracic surgery versus thoracotomy. Ann. Thorac. Surg. 1993; 56: 1285-1289.
  40. Giudicelli R., Thomas P., Lonjon T. et al. Video-assisted minithoracotomy versus muscle-sparing thoracotomy for performing lobectomy. Ann. Thorac. Surg. 1994; 58: 712-717.
  41. Hazelrigg S. R., Landreneau R. J., Boley T. M. et al. The effect of muscle-sparing versus standard posterolateral thoracotomy on pulmonary function, muscle strength, and postoperative pain. J. Thorac. Cardiovasc. Surg. 1991; 101: 394-400.
  42. Passlick B., Born Ch., Sienel W., Thetter O. Incidence of chronic pain after minimal-invasive surgery for spontaneous pneumothorax. Eur. J. Cardiothorac. Surg. 2001; 19: 355-359.
  43. Cano I., Antön-Pacheco J., Garcia A., Rotheberg S. Video-assisted thoracoscopic lobectomy in infants. Eur. J. Cardiothorac. Surg. 2006; 29: 997-1000.
  44. Furrer M., Rechsteiner R., Eigenmann V. et al. Thoracotomy and thoracoscopy: postoperative pulmonary function, pain and chest wall complaints. Eur. J. Cardiothorac. Surg. 1997; 12: 82-87.
  45. Kirby T. J., Mack M. J., Landreneau R. J., Rice T. W. Lobectomy - video-assisted thoracic surgery versus muscle-sparing thoracotomy. A randomized trial. J. Thorac. Cardiovasc. Surg. 1995; 109: 997-1001.
  46. Jutley R., Khalil M., Rocco G. Uniportal vs standard three-port VATS technique for spontaneous pneumothorax: comparison of post-operative pain and residual paraesthesia. Eur. J. Cardiothorac. Surg. 2005; 28: 43-46.
  47. Deterding R. Evaluating infants and children with interstitial lung disease. Semin. Respir. Crit. Care Med. 2007; 28: 333- 341.
  48. Blewett C. J., Bennett W. F., Miller J. D., Urschel J. D. Open lung biopsy as an outpatient procedure. Ann. Thorac. Surg. 2001; 71: 1113-1115.
  49. Ершова К. И., Кузмичев В. А., Прищепо М. И. и др. Укрепление механического шва с помощью прокладок "Seamguard" при диагностической биопсии легкого. В кн.: Сборник трудов VIII Национального конгресса по болезням органов дыхания. Екатеринбург; 2008. 182.
  50. Lee P., Colt H. Using diagnostic thoracoscopy to optimal effect: technical know-how is key. J. Crit. Ill. 2003; 18: 255- 260.
  51. Boutin C., Astoul P. Diagnostic thoracoscopy. Clin. Chest Med. 1998; 19: 295-309.
  52. Utz J. P., Ryu J. H., Douglas W. W. et al. High short-term mortality following lung biopsy for usual interstitial pneumonia. Eur. Respir. J. 2001; 17: 175-179.
  53. Caples S. M., Ulz J. P., Allen M. S., Ryu J. H. Thoracic surgical procedures in patients with rheumatoid arthritis. J. Rheumatol. 2004; 31: 2136-2141.
  54. Jinbo M., Kaneda Y., Ueda K. et al. Thoracoscopic lung biopsy in the diagnosis of diffuse lung disease. Kyobu Geka 2004; 57: 1103-1105.
  55. Harris R. J., Kavuru M. S., Rice T. W. et al. The diagnostic and therapeutic utility of thoracoscopy. Chest 1995; 108: 828- 841.
  56. Ершова К. И., Кузмичев В. А. Применение видеоторакоскопической хирургии в диагностике саркоидоза легких и внутригрудных лимфоузлов. В кн.: Материалы Первой Международной конф. по торакоабдоминальной хирургии. М.; 2008. 274.
  57. Bottaro L., Calderan L., Dibilio D. et al. Pulmonary sarcoidosis: atypical HRCT features and differential diagnostic problem. Radiol. Med. 2004; 107: 273-285.

Copyright (c) 2010 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Address of the Editorial Office:

  • Novij Zykovskij proezd, 3, 40, Moscow, 125167

Correspondence address:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Managing Editor:

  • Tel.: +7 (926) 905-41-26
  • E-mail:


© 2018-2021 "Consilium Medicum" Publishing house

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies