Positron emission tomography in the diagnosis of atherosclerotic plaques in cancer patients
- Authors: Sergienko V.B.1, Panchkovskaya E.V.1, Manukova V.A.1, Rudas M.S.1, Sergienko VB2, Panchkovsky EV3, Manukova VA3, Rudas MS3
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Affiliations:
- Russian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies, Ministry of Health and Social Development of the Russian Federation
- Central Clinical Hospital with Polyclinic, Department for Presidential Affairs of the Russian Federation
- Issue: Vol 82, No 4 (2010)
- Pages: 45-48
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30588
Cite item
Full Text
Abstract
Materials and methods. 18F-fluorodeoxyglucose positron emission tomography (PET) was used to image unstable atherosclerotic plaques in the aorta and great vessels. Whole-body radiodiagnostic studies were retrospectively analyzed in 500 cancer patients of different ages and with different forms of neoplasms.
Results. Tomographic images showed atherosclerotic plaques in 21% of the patients with the verified diagnosis of coronary heart disease (CHD) and in 17% without its clinical manifestations.
Conclusion. The study showed it possible to identify a cardiovascular risk in cancer patients
About the authors
Vladimir Borisovich Sergienko
Ekaterina Valer'evna Panchkovskaya
Veronika Alekseevna Manukova
Marina Saturovna Rudas
V B Sergienko
Russian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies, Ministry of Health and Social Development of the Russian FederationRussian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies, Ministry of Health and Social Development of the Russian Federation
E V Panchkovsky
Central Clinical Hospital with Polyclinic, Department for Presidential Affairs of the Russian FederationCentral Clinical Hospital with Polyclinic, Department for Presidential Affairs of the Russian Federation
V A Manukova
Central Clinical Hospital with Polyclinic, Department for Presidential Affairs of the Russian FederationCentral Clinical Hospital with Polyclinic, Department for Presidential Affairs of the Russian Federation
M S Rudas
Central Clinical Hospital with Polyclinic, Department for Presidential Affairs of the Russian FederationCentral Clinical Hospital with Polyclinic, Department for Presidential Affairs of the Russian Federation
References
- Чазов Е. И. Атеросклероз. М.: Медицина; 2000.
- Falk F., Shah P., Fuster V. Coronary plaque disruption. Circulation 1995; 92: 657-671.
- Kohler T. Imaging of carotid artery lesions: a surgeon's view. In: Fuster V., ed. Syndromes of atherosclerosis: Correlations of clinical imaging and pathology. Armonk, NY: Futura Publishing Co., Inc.; 1996. 205-233.
- Davies J. R., Rudd J. H., Weissberg P. L. Molecular and metabolic imaging of atherosclerosis. J. Nucl. Med. 2004; 45 (11): 1898-1907.
- Беленков Ю. Н., Сергиенко В. Б. Роль неинвазивных методов исследования в диагностике атеросклероза. Кардиология 2007; 10: 2-6.
- Davies M. J. Acute coronary thrombosis: the role of plaque disruption and its initiation and prevention. Eur. Heart J. 1995; 16 (suppl. L): 3-7.
- Сергиенко В. Б. Радионуклидная диагностика в кардиологии. В кн.: Сторожаков Г. И. (ред.). Руководство по кардиологии. М.: Геотар Мед. 2008;т. 1: гл. 6, 169-187.
- Ambrose J. Angiographic correlations of advanced coronary lesions in acute coronary syndromes. In: Fuster V., ed. Syndromes of atherosclerosis: Correlations of clinical imaging and pathology. Armonk, NY: Futura Publishing Co., Inc.; 1996. 105-122.
- Taylor A. J., Baiery Merz C. N., Udelson J. E. 34-th Bethesda conference: Can atherosclerosis imaging techniques improve the detection of patients at risk for ischemic heart disease? J. Am. Coll. Cardiol. 2003; 41: 1855-1917.
- Bukrinsky M., Sviridov D. HIV and cardiovascular disease: Contribution of HIV-infected macrophages to development of atherosclerosis. Neurology 2007; 50 (9): 892-896.
- Mahmoudi M., Curzen N., Gallagher P. J. et al. Atherogenesis: the role of inflammation and infection. Rev. Esp. Cardiol. 2007; 60 (3): 268-275.
- Davies M. J. Stability and instability: two faces of coronary atherosclerosis. The Paul Dudley white lecture 1995. Circulation 1996; 94: 2013-2020.
- Libby P. Molecular bases of the acute coronary syndromes. Circulation 1995; 91: 2844-2850.
- Luscher T. F., Tanner F. C., Tschudi M. R., Noll G. Endothelial dysfunction in coronary artery disease. Annu. Rev. Med. 1993; 44: 395-418.
- Stefanadis C., Diamantopoulos L., Dernellis J. et al. Heat production of atherosclerotic plaques and inflammation assessed by the acute phase proteins in acute coronary syndromes. J. Mol. Cell. Cardiol. 2000; 32: 43-52.
- Dinsmore R. Imaging techniques in carotid and peripheral vascular disease. In: Fuster V., ed. Syndromes of atherosclerosis: Correlations of clinical imaging and pathology. Armonk, NY: Futura Publishing Co., Inc.; 1996. 277-289.
- Rudd J. H., Warburton E. A., Fryer T. D. et al. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation 2002; 105: 2708-2711.
- Yun M., Jang S., Cucciara A. et al. 18FDG uptake in the large arteries: a correlation study with the atherogenic risk factors Semin. Nucl. Med. 2002; 37: 70-76.
- Lederman R. J., Raylman R. R., Fisher S. J. et al. Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglucose (FDG). Nucl. Med. Commun. 2001; 22: 747-753.
- Vallabajosula S., Machac K., Knesaurek J. Imaging atherosclerotic macrophage density by positron emission tomography using F-18-flurodeoxyglucose (FDG) (abstract). J. Nucl. Med. 1996; 37 (suppl.): 38P.
- Strauss L. G., Conti P. S. The applications of PET in clinical oncology. J. Nucl. Med. 1991; 32: 623-648.
- Kubota R., Kubota K., Yamada S. et al. Microautoradiographic study for the differentiation of intratumoral macrophages, granulation tissues and cancer cells by the dynamics of fluorine-18-fluorodeoxyglucose uptake. J. Nucl. Med. 1994; 35: 104-112.
- Yun M., Yeh D., Araujo L. I. et al. F-18 FDG uptake in the large arteries: a new observation. Clin. Nucl. Med. 2001; 26: 314-319.
- Yun M., Jang S., Cucchiara A. et al. 18F-FDG uptake in the large arteries: a correlation study with the atherogenic risk factors. Semin. Nucl. Med. 2002; 32: 70-76.
- Ben-Haim S., Kupzov E., Tamir A., Israel O. Evaluation of 18F-FDG uptake and arterial wall calcifications using 18F-FDG PET/CT. J. Nucl. Med. 2004; 45: 1816-1821.
- Bleeker-Rovers C., Bredie S., van der Meer J. et al. F-18-fluorodeoxyglucose positron emission tomography in diagnosis and follow-up of patients with different types of vasculitis. Neth. J. Med. 2003; 61: 323-329.
- Rudd J. H., Warburton E. A., Fryer T. D. et al. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation 2002; 105: 2708-2711.
- Bjorkerud S., Bjorkerud B. Apoptosis is abundant in human atherosclerotic lesions, especially in inflammatory cells (macrophages and T cells), and may contribute to the accumulation of gruel and plaque instability. Am. J. Pathol. 1996; 149: 367- 380.
- Davies J. R., Rudd J. H., Weissberg P. L. Molecular and metabolic imaging of atherosclerosis. J. Nucl. Med. 2004; 45 (11): 1898-1907.
- Lees R., Lees A. Radiopharmaceutical imaging of atherosclerosis. In: Fuster V., ed. Syndromes of atherosclerosis: Correlations of clinical imaging and pathology. Armonk, NY: Futura Publishing Co., Inc.; 1996. 385-401.
- Demacker P. N., Dormans T. P., Koenders E. B., Corstens F. H. Evaluation of indium-111-polyclonal immunoglobulin G to quantitate atherosclerosis in Watanabe heritable hyperlipidemic rabbits with scintigraphy: effect of age and treatment with antioxidants or ethinylestradiol. J. Nucl. Med. 1993; 34: 1316- 1321.
- Chakrabarti M., Cheng K. T., Spicer K. M. et al. Biodistribution and radioimmunopharmacokinetics of 131J-AMA monoclonal antibody in atherosclerotic rabbits. Nucl. Med. Biol. 1995; 22: 693-695.
