myocardial responses to ischemia


Cite item

Full Text

Abstract

The paper details the types of a myocardial response to impaired blood flow, such as myocardial stunning, hibernation, ischemic preconditioning, warm-up phenomenon, ischemic postconditoning, remodeling, and infarction. According to the pathogenesis, the authors identify several types of myocardial dysfunction in transient ischemic attack - uptake, delivery; and a mixed one. It is concluded the myocardial response to damage depends on a combination of influencing factors, a number of pathophysiological processes starting in the acute phase of ischemia achieve its peak in the late period.

References

  1. Murry C. E., Jennings R. B., Reimer K. A. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Ciculation 1986; 74: 1124-1136.
  2. Kloner R. A., Bolli R., Marban E. et al. Medical and cellular implications of stunning, hibernation, and preconditioning: an NHLBI workshop. Circulation 1998; 97: 1848-1867.
  3. Каде А. Х., Петровский А. Н. Патогенетические формы ишемического повреждения миокарда. Врач и аптека XXI века 2006; № 3 (123): 4-7.
  4. Jennings R. B., Sebbag L., Schwartz L. M. et al. Metabolism of preconditioned myocardium: effect of loss and reinstatement of cardioprotection. J. Mol. Cell. Cardiol. 2001; 33: 1571- 1588.
  5. Schultz J. J., Hsu A. K., Gross G. J. Ischemic preconditioning in the intact rat heart is mediated by 1 but not μ- or -opioid receptors. Circulation 1998; 97: 1282-1289.
  6. Tang X. L., Rizvi A. N., Qui Y. et al. Evidence that the hydroxyl radicaltriggers late preconditioning against myocardial stunning in consciousrabbits. Circulation 1997; 96 (suppl. I): I-255.
  7. Alpert J. S., Dalen J. E., Rahimtoola S. H. Valvular heart disease. 3-rd ed. Amsterdam: Lippincott: Williams & Wilkins; 2000.
  8. Mentzer R. M., Rakko P. S., Molina-Viamonte V. et al. Safety, tolerance, and efficacy of adenosine as an additive to blood cardioplegia in humansduring coronary artery bypass surgery. Am. J. Cardiol. 1997; 79: 38-43.
  9. Downey J. M., Yellon D. M. The biology of preconditioning. In: Heyndrickx G. R., Vatner S. F., Wijns W., eds. Stunning, hibernation and preconditioning: Clinical pathophysiology of myocardial ischemia. Philadelphia, Pa: Lippincott-Raven Publishers; 1997. 105-119.
  10. Саидова М. А. Современные методы диагностики жизнеспособного миокарда. Кардиология 2005; 9: 47- 54.
  11. Аляви А. Л., Зуфаров М. М., Туляганова Д. К. Обратимые дисфункции жизнеспособного миокарда у больных ишемической болезнью сердца. Клин. мед. 2002; 80 (8): 18- 22.
  12. Цыпленкова В. Г. Критические заметки по поводу парадигмы "гибернирующий и оглушенный миокард". Кардиология 2005; 9: 43-46.
  13. Hawaleshka A., Jacobsohn E. Ischaemic preconditioning. Mechanisms and potential clinical applications. Can. J. Anaesth. 1998; 45: 670-682.
  14. Przyklenk K., Kloner R. A. Ischemic preconditioning. Exploring the paradox. Progr. Cardiovasc. Dis. 1998; 40: 517-547.
  15. Fleet W. F., Johnson T. A., Graebner C. A. et al. Effect of serial brief ischemic episodes on extracellular K+, pH, and activation in the pig. Circulation 1985; 72: 922-932.
  16. Sebbag L., Brooks S. E., Jennings R. B. et al. Cardioprotection, lost 3 hours after ischemic preconditioning (PC) can be fully restored by repeated preconditioning in dogs: significance of ST-segment changes for detecting cardioprotection. Eur. Heart J. 1997; 1 8: 162.
  17. Hagar J. M., Hale S. L., Kloner R. A. Effects of preconditioning ischemia on reperfusion arrhythmias after coronary artery occlusion and reperfusion in the rat. Circ. Res. 1991; 68: 61- 68.
  18. Kyriakidis M. K., Petropoulakis P. N., Tentolouris C. A. et al. Relation between changes in blood flow of the contralateral coronary artery and the angiographic extent and function of recruitable collateral vessels arising from this artery during balloon coronary occlusion. J. Am. Coll. Cardiol. 1994; 23: 869- 878.
  19. Ikonomidis J. S., Tumiati L. C., Weisel R. D. et al. Preconditioning human ventricular cardiomyocytes with brief periods of simulated ischaemia. Cardiovasc. Res. 1994; 28: 1285-1291.
  20. Rose E., Yao Z. Evidence for involvement of opioidreceptors in ischemic preconditioning in rat hearts. Am. J. Physiol. 1995; 268: H2157-H 2161.
  21. Ping P., Zhang J., Qiu Y. et al. Ischemic preconditioning induces selective translocation of PKC isoforms and in the heart of conscious rabbits without subcellular redistribution of total PKC activity. Circ. Res. 1997; 81: 404-414.
  22. Liu Y., Sato T., O'Rourke B., Marban E. Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection. Circulation 1998; 97: 2463-2469.
  23. Takano H., Bolli R., Black R. G. et al. A1 or A3 adenosine receptors inducelate preconditioning against infarction in conscious rabbits by different mechanisms. Circ. Res. 2001; 88: 520-528.
  24. Yellon D. M., Baxter G. F., Garcia-Dorado D. et al. Ischaemic preconditioning. Present position and future directions. Cardiovasc. Res. 1998; 37: 21-33.
  25. Topol E. J., Lincoff A. M., Califf R. M. et al. Randomised placebo-controlled and balloon-angioplasty-controlled trial to assess safety of coronary stenting with use of platelet glycoprotein-IIb/IIIa blockade. Lancet 1998; 352: 87-92.
  26. Бузиашвили Ю. И., Ключников И. В., Мелконян А. М. и др. Ишемическое ремоделирование левого желудочка (определение, патогенез, диагностика, медикаментозная и хирургическая коррекция). Кардиология 2002; 11: 65-67.
  27. Хозяинова Н. Ю., Милягина И. В., Царева В. М. Влияние фозиноприла на артериальное давление, ремоделирование, вариабельность сердечного ритма и микроциркуляцию больных артериальной гипертонией. В кн.: Человек и лекарство: Тезисы докладов 10-го Российского нац. конгресса. М.; 2003. 398-399.
  28. Хозяинова Н. Ю., Милягина И. В., Царева В. М. Жесткость артериальной стенки, дисперсия интервала QT при разных вариантах геометрического ремоделирования левого желудочка у больных артериальной гипертонией с дисфункцией левого желудочка. В кн.: Тезисы докладов науч. конф. Общества специалистов по сердечной недостаточности. М.; 2003. 33.
  29. Khozyainova N., Milyagin V. The arterial stiffness and cardiovascular remodeling in hypertensive patients. Jn: Proceedings of the 23-rd Annual scientific meeting of the Belgian Society of Cardiology. Brussels; 2004. 27.
  30. ACC/AHA 2007 Guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction. Circulation 2007; 116: el48-e304.
  31. Thygesen K., Alpert J. S., White H. D. on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction. Eur. Heart J. 2007; 28 (20): 2525-2538.
  32. Sybers H. D., Ashraf M., Braithwaite J. R., Mai-Pai Lok. Early myocardial infarction. Arch. Pathol. 1972; 93: 49-54.
  33. Капустин А. В., Бельченко Д. И., Антонова Л. П. и др. О некоторых изменениях миокарда и крови лиц, умерших скоропостижно от ишемической болезни сердца. В кн.: Судебно-медицинские записки. Кишинев: Изд-во "Штиинца"; 1977. 55-57.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2010 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 

Address of the Editorial Office:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Correspondence address:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Managing Editor:

  • Tel.: +7 (926) 905-41-26
  • E-mail: e.gorbacheva@ter-arkhiv.ru

 

 © 2018-2021 "Consilium Medicum" Publishing house


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies