Bol' v nizhney chasti spiny u molodykh - novyy podkhod k terapii


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Abstract

Aim. To evaluate the efficiency and safety of arthrofoon versus sublingual nimesulide in patients with degenerative disc disease (DDD) in two parallel groups.
Subjects and methods. Fifty patients (males and females) aged 18-35 years who had acute and chronic low back pain (LBP) (visual analog scale (VAS), > 40 mm) associated with DDD were enrolled in the study. Therapeutic efficiency was evaluated from the intensity of pain (VAS), spinal function (Schober's test and Tomayer's test), the severity of disease (VAS), assessed by a physician and a patient, and the frequency of recurrent pain episodes.
Results. The evaluation of the efficacy of arthrofoon showed a statistically significant positive change in pain (VAS), which corresponded to that in the indices of the pain syndrome during nimesulide administration. There was a statistically significant reduction in the frequency of recurrences in patients with chronic intermittent LBP treated with arthrofoon (p < 0.01). Arthrofoon used alone and in combination with paracetamol demonstrated a good safety profile.
Conclusion. In DDD-associated LBP, the use of arthrofoon is effective and safe in young patients with both the acute (in combination with nonsteroidal anti-inflammatory drugs as a short course) and chronic (requiring long-term anti-inflammatory therapy) types of the disease.

References

  1. Насонова В. А. Боль в нижней части спины - большая медицинская и социальная проблема, методы лечения. Consilium Medicum 2004; 6 (8): 24-31.
  2. Carragee E. J., Hannibal M. Diagnostic evaluation of low back pain. Orthop. Clin. N. Am. 2004; 35: 7-16.
  3. Carey T. S., Garrett J. M., Jackman A. et al. Recurrence and care seeking after acute back pain: results of a long-term follow-up study. North Carolina Back Pain Project. Med. Care 1999; 37: 157-164.
  4. Deyo R. A., Weinstein J. N. Low back pain. N. Engl. J. Med. 2001; 344: 363-370.
  5. Hakala P., Rimpel A., Salminen J. J. et al. Back, neck, and shoulder pain in Finnish adolescents: national cross sectional surveys. Br. Med. J. 2002; 325 (7367): 743.
  6. Salminen J. J., Erkintalo M. O., Pentti J. et al. Recurrent low back pain and early disc degeneration in the young. Spine 1999; 24 (13): 1316-1321.
  7. Fardon D. F., Milette P. C. Nomenclature and classification of lumbar disk pathology: recommendations of the combined task forces of the North American Spine Society, American Society of Spine Radiology, and American Society of Neuroradiology. Spine 2001; 26: 93-113.
  8. Carey T. S., Evans A., Hadler N. M. et al. Careseeking among individuals with chronic low back pain. Spine 1995; 20: 312- 317.
  9. Modic M. T., Steinberg P. M., Ross J. S. et al. Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology 1988; 166: 193-199.
  10. Borenstein D. Эпидемиология, этиология, диагностическая оценка и лечение поясничной боли. Международ. мед. журн. 2000; 35: 36-42.
  11. Эпштейн О. И. Сверхмалые дозы. История одного исследования. М.: Изд-во РАМН; 2008.
  12. Алиханов Б. А. Опыт длительного применения сверхмалых доз антител к фактору некроза опухоли-α при остеоартрозе: эффективность и переносимость. Клиницист 2007; 4: 62-67.
  13. Бадокин В. В., Корсакова Ю. Л. Терапевтическая активность и безопасность артрофоона при псориатическом артрите. Консилиум 2006; 8 (8): 126-130.
  14. Мазуров В. И., Рассохин В. В. Роль артрофоона в комплексном лечении ревматоидного артрита. Науч.-практ. ревматол. 2007; 5: 53-59.
  15. Хитров Н. А. Периартрит плечевого сустава: варианты течения и лечения артрофооном. Тер. арх. 2007; 79 (5): 40- 46.

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