Pilot experience of using modified high-dose therapy NHL-BFM-90 in diffuse large B-cell lymphosarcoma with primary skin involvement. A case report


Primary skin large B-cell lymphosarcomas (PLBCL) present with skin lesions, other organs and systems are not involved. As CHOP courses are not high effective in PLBCL, we were the first to treat a patient with modified block therapy NHL BFM-90. A complete remission was achieved after the first course of polychemotherapy and was consolidated by two courses of treatment. Further follow-up is needed.


  1. Slater D. N. The new World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas: a practical marriage of two giants. Br. J. Dermatol. 2005; 153 (5): 874-880.
  2. Willemze R. Cutaneous B-cell lymphoma. In: Canellos G. P., Lister T. A., Young B. (eds.) The lymphomas. 2-nd ed. Philadelphia: Saunders Elsevier; 2006. 415-423.
  3. Grange F., Beylot-Barry M., Courville P. et al. Primary cutaneous diffuse large B-cell lymphoma, leg type. Arch. Dermatol. 2007; 143 (9): 1144-1150.
  4. Магомедова А. У., Кравченко С. К., Кременецкая А. М. и др. Модифицированная программа NHL-BFM-90 в лечении больных диффузной В-крупноклеточной лимфосаркомой. Тер. арх. 2006; 10: 44-47.
  5. Магомедова А. У., Волкова Я. К., Кравченко С. К. и др. Профилактика нейролейкемии у взрослых больных диффузной В-крупноклеточной лимфосаркомой лимфоидных органов. В кн.: Материалы Международной науч.-практ. конф., посвящ. 75-летию основания Гематологического науч. центра им. проф. Р. О. Еоляна. Ереван; 2008. 77.

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