Pilot experience in the treatment of poor-prognosis primary diffuse large-B-cell lymphosarcoma of the bones and soft tissues with a modified program NHL-BFM-90

  • Authors: Morozova A.K.1, Zvonkov E.E.1, Kremenetskaya A.M.1, Magomedova A.U.1, Obukhova T.N.1, Mamonov V.E.1, Baryakh E.A.1, Gubkin A.V.1, Lukina A.I.1, Ilyushkina E.A.1, Fink O.S.1, Perestoronina T.N.1, Kravchenko S.K.1, Morosova AK1, Zvonkov EE1, Kremenetskaya AM1, Magomedova AU1, Obukhova TN1, Mamonov VE1, Baryakh EA1, Gubkin AV1, Lukina AI1, Ilyushkina EA1, Fink OS1, Perestoronina TN1, Kravchenko SK1
  • Affiliations:
  • Issue: Vol 81, No 7 (2009)
  • Pages: 61-65
  • Section: Editorial
  • URL: https://ter-arkhiv.ru/0040-3660/article/view/30405
  • Cite item

Abstract


Aim. To evaluate efficacy of intensive modified program NHL-BFM-90 (mNHL-BFM-90) in adult poor-prognosis patients with diffuse large B-cell lymphosarcoma (DLBCL) of the bones and soft tissues.
Material and methods. The mNHL-BFM-90 program was used in the treatment of 3 male and 2 female patients aged 17-69 years (median 42 years). Four patients had DLBCL of the bones and one patient - DLBCL of the soft tissues. All the patients had tumors more than 10 cm in size. B-symptoms, a high concentration of lactate dehydrogenase (LDG) were registered in 3 patients. One patient had stage IE by Ann-Arbor, two - stage IIE (involvement of regional lymph nodes), two - stage ME (multiple bone lesions). A total of 4-6 blocks of polychemotherapy according to mNHL-BFM-90 program were performed.
Results. Complete remissions were achieved in all the patients. They had no recurrences after 6 to 20 month (median 13 months) follow-up.
Conclusion. Positive results of the program mNHL-BFM-90 in poor-prognosis patients with DLBCL of the bones and tissues necessitate further studies of this therapy.

About the authors

Anna Konstantinovna Morozova

Email: annmo@mail.ru

Evgeniy Evgen'evich Zvonkov

Email: zvonkov@blood.ru

Aleksandra Mikhaylovna Kremenetskaya

Email: mtkalexandra@gmail.com

Aminat Umuraskhabovna Magomedova

Email: maminat@mail.ru

Tat'yana Nikiforovna Obukhova

Email: obukhova@blood.ru

Vasiliy Evgen'evich Mamonov

Email: vasil@blood.ru

Elena Aleksandrovna Baryakh

Email: baryakh@mail.ru

Andrey Vladimirovich Gubkin

Email: gubkin@blood.ru

Aleksandra Ivanovna Lukina

Email: aleksandra.lukina@gmail.com

Ekaterina Alekseevna Ilyushkina

Email: littlekatrin@mail.ru

Olesya Sergeevna Fink

Email: fonko@hotbox.ru

Tat'yana Nikolaevna Perestoronina

Email: t.perestoronina@mail.ru

Sergey Kirillovich Kravchenko

Email: krav@blood.ru

A K Morosova

E E Zvonkov

A M Kremenetskaya

A U Magomedova

T N Obukhova

V E Mamonov

E A Baryakh

A V Gubkin

A I Lukina

E A Ilyushkina

O S Fink

T N Perestoronina

S K Kravchenko

References

  1. Воробьев А. И., Кременецкая А. М., Харазишвили Д. В. Диффузные В-крупноклеточные лимфосаркомы. В кн.: Воробьев А. И. (ред.). Руководство по гематологии. 3-е изд. М.: "Ньюдиамед"; 2002; т. 2: 57-62.
  2. Воробьев А. И. Атлас "Опухоли лимфатической системы". М.: Ньюдиамед; 2007. 167-205.
  3. Gill P., Wenger D., Inwards D. Primary lymphomas of bone. Clin. Lymphoma & Myeloma 2005; 6 (2): 140-142.
  4. Ramadan K. M., Shenkier T., Sehn L. H. et al. 131 patients with primary bone lymphoma: a population-based study of successively treated cohorts from the British Columbia Cancer Agency. Ann. Oncol. 2007; l8: l29-135.
  5. Travis W. D., Banks P. M., Reiman H. M. Primary extranodal soft tissue lymphome of the extremities. Am. J. Surg. Pathol. 1987; 11: 359-366.
  6. Parker F., Jackson H. Primary reticulum cell sarcoma of bone. Surg. Gynecol. Obstet. 1939; 68: 45-53.
  7. Oberling C. Les reticulosarcomes et les reticuloendotheliosarcomes de la moelle osseuse (sarcomes D'Ewing), Bull. Cancer (Paris) 1928; 17: 259-296.
  8. Freeman C., Berg J. W., Cutler S. J. Occurrence and prognosis of extranodal lymphomas. Cancer (Philad.) 1972; 29: 252- 260.
  9. Beggs I. Primary muscle lymphoma. Clin. Radiol. 1997; 52: 203-212.
  10. Lee V. S. et al. Primary muscle lymphoma: clinical and imaging findings. Radiology 1997; 203: 237-244.
  11. Grunshaw N. D., Chalmers A. G. Skeletal muscle lymphoma. Clin. Radiol. 1992; 45: 399-400.
  12. Ludwig K. Muskuloskelettale lymphome. Radiologe 2002; 42: 988-992.
  13. Hwang S. Imaging of lymphoma of musculoskeletal system. Radiol. Clin. N. Am. 2008; 46: 379-396.
  14. Ruzek K. A., Wenger D. E. The multiple faces of lymphoma of the musculoskeletal system. Skeletal Radiol. 2004; 33: 1-8.
  15. Lewis V. O., Primus G., Anastasi J. et al. Oncologic outcomes of primary lymphomas of bone in adults. Clin. Orthop. 2003; 415: 90-97.
  16. Lones M. A., Perkins Sh. L., Sposto R. et al. Non-Hodgkin's lymphoma arising in bone in children and adolescents is associated with an excellent outcome: a children's cancer group report. J. Clin. Oncol. 2002; 20 (9): 2293-2301.
  17. Murphy S., Fairclough D., Hutchison R. et al. Non-Hodgkin's lymphomas of childhood: an analysis of the histology, staging, and response to treatment of 338 cases at a single institution. J. Clin. Oncol. 1989; 7(2): 186-193.
  18. Barbieri E., Cammellin C., Mauro F. et al. Primary Non-Hodgkln lymphoma of the bone treatment and analysis of prognostic factors. Int. J. Radiat. Oncol. Biol. Phys. 2004; 59 (3): 760-764.
  19. Звонков Е. Е., Кременецкая А. М., Кравченко С. К. и др. Эффективность консервативной терапии лимфосаркомы желудка. Тер. арх. 2008; 7: 18-27.
  20. Reiter A., Schrappe M., Ludwig W.-D. et al. Improved treatment results in childhood B-cell neoplasms with tailored intensification of therapy: a report of the Berlin-Frankfurt-Munster Group Trial NHL-BFM-90. Blood 1999; 94 (10): 3294- 3297.
  21. Барях Е. А., Звонков Е. Е., Кременецкая А. М. и др. Лечение беркиттоподобной лимфомы взрослых. Тер. арх. 2006; 7: 53-58.
  22. Zvonkov E., Baryakh E., Krasilnikova B. et al. Modified NHL-BFM-90 program in primary gastric diffuse large B-cell lymphoma (PGDLBCL) with adverse prognostic factors. Leukemia Res. 2007; 31: S91.
  23. Кравченко С. К., Барях Е. А., Замятина В. И. и др. Высокодозная терапия лимфомы Беркитта у больных старше 40 лет. Тер. арх. 2008; 7: 9-18.
  24. Fairbanks R. K., Bonner J. A., Inwards C. Y. et al. Treatment stage IE primary lymphoma of bone. Int. J. Radiat. Oncol. Biol. Phys. 1994; 28: 363-372.
  25. Marhal D. T., Amdur R. J., Scarborough M. T. et al. Stage IE primary non Hodgkin lymphoma of bone. Clin. Orthop. 2002; 26 (4): 216-222.
  26. Fidas P., Spiro I., Scobczak M. L. et al. Long-term results of combined modality therapy in primary bone lymphomas. Int. J. Radiat. Oncol. Biol. Phys. 1999; 45: 1213-1238.

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