Content of C-reactive protein, interleukin-1, interleukin-6 and interleukin-1 receptor antagonist in the blood of patients with early osteoarthrosis of the knee joints

Abstract


Aim. To analyse the levels of C-reactive protein (CRP), IL-1, IL-6 and IL-1 receptor antagonist (IRA) in the blood of patients with early gonarthrosis (GA).
Material and methods. Clinical, x-ray and arthrosonographic examinations to stage GA, to identify knee joint synovitis, degree of pain and joint dysfunction were made in 62 males and females with early GA and 20 healthy donors. The levels of CRP, IL-1, IL-6 and IRA were measured with reference to GA stage and activity of the inflammatory process.
Results. CRP levels did not differ significantly in synovitis and no synovitis, in different GA stages, in patients and normal controls. Cytokines, except IL-6, were significantly higher in patients with knee joint osteoarthrosis (KJO). The highest levels of IL-1 and the lowest of IRA occurred in the group of roentgen-negative patients versus patients with the pathological process of stage I and II. The cytokines content did not reflect severity of inflammation in the knee joints.
Conclusion. In early GA inflammation may be not systemic. CRP level does not correlate with activity of local joint inflammation. Most active cartilage tissue degradation takes place at the earliest (preroentgenological) stage of KJO. This stage is most appropriate for initiation of active pathogenetic therapy of the disease.

References

  1. Алексеева Л. И. Современные представления о диагностике, лечении и профилактике остеоартроза. Рус. мед. журн. 2000; 8 (9): 377-382.
  2. Вялков А. И., Гусев Е. И., Зборовский А. Б., Насонова В. А. Основные задачи Международной декады (The Bone and Joint Decade 2000-2010) в совершенствовании борьбы с наиболее распространенными заболеваниями опорно-двигательного аппарата в России. Науч.-практ. ревматол. 2001; 2: 4-13.
  3. Насонова В. А., Эрдес Ш. О Всемирной Декаде костно-суставных заболеваний 2000-2010. Науч.-практ. ревматол. 2000; 4: 14-16.
  4. Рудин Г. А. Лечение остеоартроза коленного сустава. Мед. газета 2005; 5: 13.
  5. Хитров Н. А. Структура заболеваемости остеоартрозом и проблема наличия сопутствующей патологии. Тер. арх. 2005; 12: 59-64.
  6. Ayral X., Pickering E. H., Woodworth T. G. et al. Synovitis predict the arthroscopic progression of medial tibiofemoral osteoarthritis. Arthr. and Rheum. 2001; 44 (a): 101.
  7. Benito M. J., Veale D. J., Fitz O. Synovial tissue inflammation in early and late osteoarthritis. Ann. Rheum. Dis. 2005; 64: 1263-1267.
  8. Chu S.-C., Yang S.-F., Lue K.-M. et al. Regulation of gelatinases expression by cytokines, endotoxin, and pharmacological agents in the human osteoarthritic knee. Connect. Tissue Res. 2004; 45: 142-150.
  9. Haywood L., McWilliams D. F. Inflammation and angiogenesis in osteoarthritis. Arthr. and Rheum. 2003; 48: 2173-2177.
  10. Sharif M., Elson C. J., Dieppe P. A. et al. Elevated serum C-reactive protein levels in osteoarthritis. Br. J. Rheumatol. 1997; 36: 140-141.
  11. Sowers M. F. C-reactive protein as a biomarker of emergent osteoarthritis. Osteoarthr. and Cartilage 2002; 10: 595-601.
  12. Wolfe F. The C-reactive protein but not erythrocyte sedimentation rate is associated with clinical severity in patients with osteoarthritis of the knee and hip. Rheumatol. Drags 1997; 52 (3): 27-38.

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Copyright (c) 2020 Svetlova M.S., Vezikova N.N., Romashina V.V., Sobanina T.S., Pavlov Y.L., Cheplyukova I.A., Svetlova M.S., Vezikova N.N., Romashina V.V., Sobanina T.S., Pavlov Y.L., Cheplyukova I.A.

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