The role of atherosclerosis risk factors in development of coronary artery disease in young men

  • Authors: Ezhov MV1, Afanas'eva OI1, Kambegova AA1, Afanas'eva MI1, Trukhacheva EP1, Naumov VG1, Pokrovskiy SN1, Ezhov MV1, Afanasyeva OI1, Kambegova AA1, Afanasyeva MI1, Trukhacheva EP1, Naumov VG1, Pokrovsky SN1
  • Affiliations:
  • Issue: Vol 81, No 5 (2009)
  • Pages: 50-53
  • Section: Articles
  • URL: https://ter-arkhiv.ru/0040-3660/article/view/30341
  • Cite item

Abstract


Aim. To determine distribution of different atherosclerosis risk factors and their correlation with severity of coronary arteries (CA) affection in young men.
Material and methods. A total of 235 males aged 28-45 years were examined with coronarography which detected more than 50% narrowing in one or several major CA in 200 patients (the study group with coronary artery disease), 35 males without coronary stenosis served control. Atherosclerosis risk factors, serum lipids, lipoprotein(a), fibrinogen, C-reactive protein (CRP) were assessed.
Results. Smoking and hyperlipidemia (HLE) were registered in the study group more frequently. The level of lipoprotein(a) above 30 mg/dl was recorded in 98 (49%) and 7 (20%) patients of the study and control group, respectively (p = 0.001). As shown by a correlation analysis, the number of affected CA was associated with smoking (r = 0.2; p < 0.001), HLE (r = 0.23; p < 0.001), concentration of total cholesterol (r = 0.23; p < 0.0.001), lipoprotein (a) (r = 0.26; p < 0.001) and CRP (r = 0.26; p < 0.05). The level of lipoprotein(a) in patients with myocardial infarction and occluded artery was significantly higher than in patients without myocardial infarction and non-occlusive CA affection.
Conclusion. The presence and severity of coronary atherosclerosis in young men with coronary artery disease are associated with smoking, HLE and high concentration of lipoprotein (a).

About the authors

M V Ezhov

O I Afanas'eva

A A Kambegova

M I Afanas'eva

E P Trukhacheva

V G Naumov

S N Pokrovskiy

M V Ezhov

O I Afanasyeva

A A Kambegova

M I Afanasyeva

E P Trukhacheva

V G Naumov

S N Pokrovsky

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