Quantitative repolarization indices in diagnosis of left ventricular hypertrophy in hypertensive patients

Full Text

Abstract

Aim. To determine informative value of quantitative parameters of orthogonal ECG repolarization phase in diagnosis of left ventricular hypertrophy (LVH) in hypertensive patients.
Material and methods. A total of 210 healthy subjects and 241 hypertensive patients with LVH (LV myocardium mass index > 125 g/m2 in males and > 110 g/m2 in women) comprised two groups - control and test. The study was made of quantitative parameters (components X, Y, Z, modules and angles of azimuth and elevation) of wave T integral vector, wave T maximal vector, ST vector, ventricular gradient; spatial and projection areas of wave T, the angle between integral vectors of spatial waves QRS and T (phi angle).
Results. The test group had reduced X, Y components and elevated vectors, their azimuth and phi angle. Most informative for repolarization were components X of T maximal and integral vectors being as informative as Rx+Sz and Cornel product. The method of multiple regression analysis was used to plot discriminant function taking account of most informative indices of depolarization and repolarization - Rx+Sz and X component of T maximal vector. The area under ROC curve for this function was greater than for the variables alone and Cornel product in both groups (0.90 ± 0.02 and 0.86 ± 0.02, p < 0.05 for the control and test group, respectively).
Conclusion. Quantitative parameters of repolarization phase can improve LVG diagnosis in hypertensive patients.

References

  1. Okin P. M., Devereux R. B., Nieminen M. S. et al. Electrocardiographic strain pattern and prediction of cardiovascular morbidity and mortality in hypertensive patients. Hypertension 2004; 44: 48-54.
  2. Okin P. M., Devereux R. B., Nieminen M. S. et al. Electrocardiographic strain pattern and prediction of new-onset congestive heart failure in hypertensive patients: The Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) Study. Circulation 2006; 113: 67-73.
  3. Levy D., Salomon M., D'Agostino R. B. et al. Prognostic implications of baseline electrocardiographic features and their serial changes in subjects with left ventricular hypertrophy. Circulation 1994; 90 (4): 1786-1793.
  4. Блинова Е. В., Сахнова Т. А., Саидова М. А. и др. Информативность показателей ортогональной электрокардиограммы в диагностике гипертрофии левого желудочка. Тер. арх. 2007; 4: 15-18.
  5. Hanley J. A., McNeil B. J. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology 1983; 148: 839-843.
  6. Блинова Е. В., Сахнова Т. А., Кожемякина Е. Ш. и др. Изменения векторкардиографических и дэкартографических параметров реполяризации желудочков в зависимости от возраста у здоровых лиц. Функц. диагн. 2008; 2 (спец. вып.: Материалы 9-го конгресса Российского о-ва холтеровского мониторирования и неинвазивной электрофизиологии, Суздаль, 14-15 мая 2008): 44.
  7. Dilaveris P., Gialafos E., Poloniecki J. et al. Changes of the T-wave amplitude and angle: an early marker of altered ventricular repolarization in hypertension. Clin. Cardiol. 2000; 23 (8): 600-606.
  8. Dilaveris P., Gialafos E., Pantazis A. et al. The spatial QRS-T angle as a marker of ventricular repolarisation in hypertension. J. Hum. Hypertens. 2001; 15 (1): 63-70.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2009 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 

Address of the Editorial Office:

  • Novij Zykovskij proezd, 3, 40, Moscow, 125167

Correspondence address:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Managing Editor:

  • Tel.: +7 (926) 905-41-26
  • E-mail: e.gorbacheva@ter-arkhiv.ru

 

© 2018-2021 "Consilium Medicum" Publishing house


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies