Assessment of major artery stiffness: new perspectives of noninvasive diagnosis of coronary atherosclerosis


Cite item

Full Text

Abstract

Aim. Arterial stiffness is a predictor of atherosclerosis. This study was conducted to develop a method of coronary atherosclerosis severity assessment by means of brachial-ankle pulse wave velocity (baPWV).
Material and methods. We measured baPWV in 119 males (age 51.67 ± 7.25) who received coronary angiographic examination (CAG). The baPWV was measured by Vasera VS-1000 (Fukuda Denshi).
Results. The patients were divided into two groups by severity of stenosis (group 1 - less than 50% stenosis, group 2 > 50%). The baPWV value was significantly greater in group 2 (n = 98, baPWV 13.15 ± 2.14 m/s, p = 0.004) than that in group 1 (n = 21, baPWV 12.13 ± 1.17 m/s). ROC-curve demonstrated that the best cut-off point of the baPWV for predicting occlusive atherosclerosis was 12.2 m/s. The area under ROC-curve was 0.66 (p = 0.034). An univariate binary logistic regression model demonstrated that only baPWV had a significant odds ratio for coronary stenosis > 50%: 2.68 (95% CI = 1.01-7.15), p = 0.043. Other risk factors were not significantly associated with severity of stenosis.
Conclusion. The baPWV significantly reflects the severity of stenosis in middle-aged males opening new perspectives of noninvasive detection of coronary artery atherosclerosis in middle-aged males.

References

  1. Thom T., Haase N., Rosamond W. et al. Heart disease and stroke statistics: 2006 update. A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2006; 113: 85-151.
  2. Myerburg R. J., Kessler K. M., Castellanos A. Sudden cardiac death: epidemiology, transient risk, and intervention assessment. Ann. Intern. Med. 1993; 119: 1187-1197.
  3. Brindle P. M., Beswick A. D., Fahey T., Ebrahim S. B. The accuracy and impact of risk assessment in the primary prevention of cardiovascular disease: a systematic review. Heart 2006; 92: 1752-1759.
  4. Kagan A. R., Uemura K. Atherosclerosis of the aorta and coronary arteries in five towns: material and methods. Bull. Wld Hlth Org. 1976; 53: 489-499.
  5. van Popele N. M., Grobbee D. E., Bots M. L. et al. Association between arterial stiffness and atherosclerosis: the Rotterdam Study. Stroke 2001; 32: 454-460.
  6. Hirai T., Sasayama S., Kawasaki T., Yagi S. Stiffness of systemic arteries in patients with myocardial infarction: a noninvasive method to predict severity of coronary atherosclerosis. Circulation 1989; 80: 78-86.
  7. Dart A. M., Lacombe F., Yeoh J. K. et al. Aortic distensibility in patients with isolated hypercholesterolaemia, coronary artery disease, or cardiac transplant. Lancet 1991; 338: 270-273.
  8. Amar J., Ruidavets J. B., Chamontin B. et al. Arterial stiffness and cardiovascular risk factors in a population-based study. J. Hypertens. 2001; 19: 381-387.
  9. Meaume S., Benetos A., Henry O. F. et al. Aortic pulse wave velocity predicts cardiovascular mortality in subjects > 70 years of age. Arterioscler. Thromb. Vasc. Biol. 2001; 21: 2046-2050.
  10. Илюхин О. В., Калганова Е. Л., Илюхина М. В., Лопатин Ю. М. Скорость распространения пульсовой волны у больных коронарным атеросклерозом. Кардиология 2005; 6: 42.
  11. Милягин В. А., Милягина И. В., Грекова М. В. и др. Новый автоматизированный метод определения скорости распространения пульсовой волны. Функц. диагн. 2004; 1: 33-39.
  12. Карпов Ю. А., Сорокин Е. В. Стабильная ишемическая болезнь сердца: стратегия и тактика лечения. М.: Реафарм; 2003.
  13. Van Bortel L. M., Duprez D., Starmans-Kool M. J. et al. Clinical applications of arterial stiffness. Task Force III: recommendations for user procedures. Am. J. Hypertens. 2002; 15 (5): 445-452.
  14. Беленков Ю. Н., Матчин Ю. Г., Кузьмина А. Е. и др. Клиническая и экономическая эффективность проведения диагностической коронарографии в амбулаторных условиях. Кардиология 2008; 48 (3): 4-8.
  15. Диагностика и лечение стабильной стенокардии: Российские рекомендации. М.; 2004.
  16. Garrod A. H. On sphygmography. Anat. Physiol. 1872; 7 (1): 98-105.
  17. Yamashina A., Tomiyama H., Takeda K. et al. Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens. Res. 2002; 25 (3): 359-364.
  18. Yu W.-C., Chuang S.-Y., Lin Y.-P., Chen C.-H. Brachial-ankle vs carotid-femoral pulse wave velocity as a determinant of cardiovascular structure and function. J. Hum. Hypertens. 2008; 22: 24-31.
  19. Tomiyama H., Koij Y., Yambe M. et al. Brachial-ankle pulse wave velocity is a simple and independent predictor of prognosis in patients with acute coronary syndrome. Circ. J. 2005; 69: 815-822.
  20. Агеев Ф. Т., Орлова Я. А., Нуралиев Э. Ю. и др. Скорость пульсовой волны - предиктор развития сердечно-сосудистых осложнений у мужчин с ишемической болезнью сердца. Кардиол. вестн. 2007; II (XIV), 1, 17-22.
  21. Ono K., Tsuchida A., Kawai H. et al. For the GUNMA Dialysis and ASO Study Group. Ankle-brachial blood pressure index predicts all-cause and cardiovascular mortality in hemodialysis patients. J. Am. Soc. Nephrol. 2003; 14: 1591-1598.
  22. Matsuoka O., Otsuka K., Murakami S. et al. Arterial stiffness independently predicts cardiovascular events in an elderly community - Longitudinal investigation for the Longevity and Aging in Hokkaido County [LILAC] study. Biomed. and Pharmacother. 2005; 59 (1): S40-S44.
  23. Farrar D. J., Bond M. G., Riley W. A., Sawyer J. K. Anatomic correlates of aortic pulse wave velocity and carotid artery elasticity during atherosclerosis progression and regression in monkeys. Circulation 1991; 83: 1754-1763.
  24. Imanishi R., Seto S., Toda G. et al. High brachial-ankle pulse wave velocity is an independent predictor of the presence of coronary artery disease in men. Hypertens. Res. 2004; 27 (2): 71-78.
  25. Fukuda D., Yoshiyama M., Shimada K. et al. Relation between aortic stiffness and coronary flow reserve in patients with coronary artery disease. Heart 2006; 92 (6): 759-762.
  26. Liu H., Yambe T., Zhang X. et al. Comparison of brachial-ankle pulse wave velocity in Japanese and Russians. Tohoku J. Exp. Med. 2005; 207 (4): 263-270.
  27. Kennedy M., Solomon C., Manolio T. A. et al. Risk factors for declining ankle-brachial index in men and women 65 years or older: the Cardiovascular Health Study. Arch. Intern. Med. 2005; 165 (16): 1896-1902.
  28. Yamashina A., Tomiyama H., Arai T. et al. Brachial-ankle pulse wave velocity as a marker of atherosclerotic vascular damage and cardiovascular risk. Hypertens. Res. 2003; 26 (8): 615-622.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2009 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 

Address of the Editorial Office:

  • Novij Zykovskij proezd, 3, 40, Moscow, 125167

Correspondence address:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Managing Editor:

  • Tel.: +7 (926) 905-41-26
  • E-mail: e.gorbacheva@ter-arkhiv.ru

 

 © 2018-2021 "Consilium Medicum" Publishing house


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies