Efficacy of one combined inhalation drug in the treatment of patients with bronchial asthma depending on the disease duration

Abstract


Aim. To assess an effect of long-term administration of one combined inhaled drug containing glucocorticosteroids (GCS) and long-acting beta2-agonists (LABA) on patient compliance.
Material and methods. The trial included 47 patients (14 males and 33 females, mean age 48.8 ± 13.2 years) with bronchial asthma (BA) of different severity and duration (from 1 month to 42 years). The patients were divided into two groups by BA duration: 20 patients with newly diagnosed BA and 27 patients with a long history of BA. Cooperation was judged by the questionnaire Index of Cooperation in Bronchial Asthma. Control of BA for the last 4 weeks was determined according to Asthma Control Test.
Results. Patients with BA of new onset have low mean rating of compliance. One combined inhaled drug improved compliance in both groups but the improvement was less in patients with new-onset BA. The ACT-test showed that the above inhaled improve control of BA.
Conclusion. Therapy with one combined inhaled drug containing GCS and LABA is highly effective in patients with BA of different severity. This promotes higher compliance and, finally, produces better effect.

References

  1. ОбычныйАвдеев С. Н. Комбинированные ингаляционные препараты - новый подход к лечению бронхиальной астмы. Рус. мед. журн. Пульмонология. 2001; 9 (21): 940-945.
  2. Чучалин А. Г. (ред.) Глобальная стратегия лечения и профилактики бронхиальной астмы: Пер. с англ. М.: Атмосфера; 2002.
  3. Anderson H. R., Bailey P. A., Cooper J. S. et al. Morbidity and school absence caused by asthma and wheezing illness. Arch. Dis. Child. 1983; 58: 777-784.
  4. Braman S. S. The global burden of asthma. Chest. 2006; 130. (suppl. 1): 4S-12S.
  5. Cressy D. S., DeBoisblanc B. P. Diagnosis and management of asthma: a summary of the National Asthma Education and Prevention Program guidelines. National Institutes of Health. J. La Med. Soc. 1998; 150 (12): 611-617.
  6. Jones P. W. Quality of Life measurement: the value of standardization. Eur. Respir. Rev. 1997; 7 (42): 46-49.
  7. Jones P. W. Health status, quality of life and compliance. Eur. Respir. Rev. 1998; 8 (56): 239-242.
  8. Mak H., Johnston P., Abbey H., Talamo R. C. Prevalence of asthma and health service utilization of asthmatic children in the inner city. J. Allergy Clin. Immunol. 1982; 70: 367-372.
  9. Чучалин А. Г. (ред.) Глобальная стратегия лечения и профилактики бронхиальной астмы: Пер. с англ. М.: Атмосфера; 2007.
  10. Национальная программа "Бронхиальная астма у детей. Стратегия лечения и профилактика". 2-е изд. М.: Русский врач; 2006.
  11. Cochrane G. M. Compliance in asthma. Eur. Respir. Rev. 1998; 8 (56): 242-246.
  12. Keller S. Implications of the stages of change model for medication compliance. Eur. Respir. Rev. 1998; 8: 260-266.
  13. Kendrick A. H., Higgs С. М., Whitfield M. J., Laszlo G. Accuracy of perception of severity of asthma: patients treated in general practice. Br. Med. J. 1993; 307: 422-424.
  14. Vermeire P. Chairman's introduction. Eur. Respir. Rev. 1998; 8: 233-234.
  15. Rand C. S. Patient and regimen-related factors that influence compliance with asthma therapy. Eur. Respir. Rev. 1998; 8 (56): 270-274.
  16. Spector S. L., Kinsman R., Mawhinney H. et al. Compliance of patients with asthma with an experimental aerosolized medication: implications for controlled clinic. J. Allergy Clin. Immunol. 1986; 77: 65-70.
  17. Rand C. S., Wise R. A., Nides M. et al. Metered-dose inhaler adherence in a clinical trial. Am. Rev. Respir. Dis. 1992; 146: 1559-1564.
  18. Rabe K. F., Vermeire P. A., Soriano J. B., Maier W. C. Clinical management of asthma in 1999: the Asthma Insights and Reality in Europe (AIRE) study. Eur. Respir. J. 2000; 16: 802-807.
  19. Celano M., Geller R. J., Phillips K. M., Ziman R. Treatment adherence among low-income children with asthma. J. Pediatr. Psychol. 1998; 223 (6): 345-349.
  20. Chambers C. V., Markson L., Diamond J. J. et al. Health beliefs and compliance with inhaled corticosteroids by asthmatic patients in primary care practices. Respir. Med. 1999; 93 (2): 90-94.
  21. Clark N. M., Gotsch A., Rosenstock I. R. Patient, Professional and Public education on behavioral aspects of asthma: a review of strategies for change and needed research. J. Asthma. 1993; 30 (4): 241-255.
  22. Glanz K., Fiel S. B., Swartz M. A., Francis M. E. Compliance with an experimental drug regimen for treatment of asthma: its magnitude, Importance, and correlates. J. Chron. Dis. 1984; 37: 815-824.
  23. Marinker M. The current status of compliance. Eur. Respir. Rev. 1998; 8: 235-238.
  24. Salerno M., Huss K., Huss R. W. Allergen avoidance in the treatment of dust - mite allergy and asthma. Nurse Pract. 1992; 17. (10): 65.
  25. Сенкевич Н. Ю. Качество жизни и кооперативность больных бронхиальной астмой: Автореф. дис. ... д-ра мед. наук. М.; 2000.
  26. Бушуева Н. А. Влияние медико-социальных факторов, режима лечения и обучения на кооперативность больных бронхиальной астмой: Автореф. дис. ... канд. мед. наук. М.; 2000.
  27. Мещерякова Н. Н. Показатели качества жизни и кооперативности больных бронхиальной астмой при переходе на оптимизированные способы доставки дозированных аэрозолей: Автореф. дис. ... канд. мед. наук. М.; 2004.
  28. Волкова С. Н., Шестакова Г. В., Соловьева Е. В. Эффективность Симбикорта и комплаентность к лечению больных бронхиальной астмой. В кн. 13-й Национальный конгресс по болезням органов дыхания, Санкт-Петербург 10-14 нояб. 2003: Сборник тезисов докладов. СПб.; 2003. № 021.
  29. Godard Ph., Huas D., Sohier В. et al. Is the question "how is you asthma doing?" sufficient to assess asthma control in primary care? In: Abstract presented at 14th European Respiratory Society (ERS) annual congress. Sept. 2004. Glazgo; 2004. № 1756
  30. van Der Woude H. J., Aalbers R. Compliance with inhaled glucocorticoids and concomitant use of long-acting beta2-agonists. Respir. Med. 2001; 95 (5): 404-407.
  31. Белевский А. С. Тест контроля астмы - "новая игрушка" или важный инструмент. Атмосфера. Пульмонол. и аллергол. 2005; 1: 33-34.

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