H. pylori in development of allergic diseases in patients with gastroduodenal diseases

Abstract

Aim. To discover relations between allergic diseases and H.pylori infection in patients with gastroduodenal diseases.
Material and methods. The study was made of 113 patients (age 22-65, 34 males and 79 females) with chronic gastritis and duodenal ulcer. Of them, 60 patients (group 1) had concomitant allergy (urticaria, bronchial asthma, atopic dermatitis, food allergy, pollinosis), while 53 patients (group 2) had no allergy. H.pylori infection was diagnosed with the respiratory and rapid urease test, histological and cytological tests. Enzyme immunoassay determined total antibodies (AB) to H.pylori in IgG, IgA, IgM classes; IgA-AB in the kits Vector Best (Russia), IgG-AB to H.pylori in the kits of ECOLab (Russia) and total IgE in the kits IgE-EIA (Stavropol).
Results. In group 1 total AB to H.pylori were positive in 48 (80%), IgG-AB and IgA-AB to H.pylori in 38(63.3%) and 43 (71.6%) patients, respectively. In elevated concentration of AgG-AB to H.pylori 46 (76.6%) patients had elevated total IgE (mean 364 IU.l). In group 2 total AB to H.pylori were detected in 45 (85.0%) patients, IgG-AB and IgA-AB to H.pylori in 47 (88.6%) and 32 (60. 3%), respectively. Among patients with high level of IgG-AB to H.pylori in the serum high total IgE was only in 35.8% patients. Mean IgE was 250 IU/l.
Conclusion. Patients with gastroduodenal diseases associated with H.pylori and allergy and not associated had similar level of total AB to H.pylori, while higher total IgE and specific IgE-AT to H.pylori occurred in the former. Thus, H. pylori infection is associated with allergic (atopic) immune response.

References

  1. Gaspar Gala Ortiz et al. Chronic urticaria and Helicobacter H. pylori. Ann. Allergy, Asthma, Immunol. 2000; 29 (10).
  2. Бардахчьян Э. А., Ломов С. Ю., Харланова Н. Г. Роль Helicobacter pylori при развитии экстрагастродуоденальных заболеваний. Гастроэнтерология 2005; 3: 20-27.
  3. Горячкина Л. А., Борзова Е. Ю. Роль хеликобактерной инфекции в патогенезе хронической крапивницы. Аллергология 2004; 1: 102-108.
  4. Соколова Т. В. Влияние на течение атопического дерматита у взрослых инфекции Helicobacter pylori и схемы ее эрадикации. Consilium Medicum 2004; 1: 234-237.
  5. Кондрашина Э. А., Калинина Н. М., Давыдова Н. И., Барановский А. Ю. Особенности цитокинового профиля у пациентов с хроническим Helicobacter pylori, ассоциированным гастритом и язвенной болезнью. Цитокины и воспаление 2002; 4: 5-16.
  6. Останин А. А, Пальцев А. И., Лебедев А. Г. и др. Характеристика апоптоза и функциональной активности лимфоцитов у больных язвенной болезнью. Бюл. СО РАМН; 2004; 1: 111.
  7. Figura N., Perrone A., Gennari С. et al. CagA-positive Helicobacter pylori infection may increase the risk of food allergy development. J. Pharm. Pharmacol. 1999; 50 (5): 827-831.
  8. Liutu M., Kalimo K., Kalimo H., Uksila J. & Leino R. Mast cells and IgE-contaimng cells in gastric mucosa of Helicobacter pylori infected and non-infected patients with chronic urticaria. J. Eur. Acad. Dermatol. Venereol. 2004; 18 (1): 69- 72.
  9. Kolho K. L., Haapaniemi A., Haahtela Т., Rautelin H. Helicobacter pylori and specific immunoglobulin E antibodies to food allergens in children. J. Pediatr. Gastroenterol. Nutr. 2005; 40 (2): 180-183.
  10. Matysiak-Budnik Т., van Niel G., Megraud F. et al. Gastric Helicobacter infection inhibits development of oral tolerance to food antigens in mice. Infect. and Immun. 2003; 71 (9): 5219-5224.

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Copyright (c) 2008 Lazebnik L.B., Chernutskaya S.P., Gervazieva V.B., Sukhareva G.V., Lazebnik L.B., Chernutskaya S.P., Gervazieva V.B., Sukhareva G.V.

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