Email this article Effects of combined treatment with rosiglitazone and NPH insulin on carbohydrate metabolism in patients with type 2 diabetes mellitus
- Authors: Kandalintseva OA1, Ametov AS1, Kandalintseva OA1, Ametov AS1
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- Issue: Vol 80, No 12 (2008)
- Pages: 40-44
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30253
- ID: 30253
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Abstract
Aim. To study efficacy and safety of rosiglitazone + NPH insulin combined treatment in patients with type 2 diabetes mellitus (DM).
Material and methods. The trial included 43 patients with DM aged 44-75 on NPH insulin. The patients were divided into two groups. The study group received NPH insulin + a single morning dose of 4 mg/day rosiglitazone, the control group received NPH insulin only. The treatment lasted 24 weeks.
Results. 24-week therapy in the study group lowered HbA1c from 8.16 ± 0.23 to 6.82 ± 0.18% (p < 0.05), fasting glycemia - from 9.68 ± 0.48 to 6.4 ± 0.32 mmol/l, postprandial glycemia - from 12.3 ± 0.44 to 8.4 ± 0.56 mmol/l, HOMA-IR index - from 7.65 ± 1.12 to 4.26 ± 0.59. In group 2 HbA1c - from 7.84 ± 0.15 to 7.49 ± 0.17 (p < 0.05), from 9.21 ± 0.65 to 8.38 ± 0.50 mmol/l, 11.92 ± 0.53 to 9.97 ± 0.45 mmol/l, 6.77 ± 0.79 to 5.73 ± 0.63. The combined treatment produced positive changes in lipid metabolism: total cholesterol decreased from 6.37 ± 0.36 to 5.67 ± 0.32 mmol/l (p < 0.005), TG - from 2.46 ± 0.64 mmol/l to 1.82 ± 0.46 mmol/l (p < 0.005), LDLP - from 3.99 ± 0.40 to 3.58 ± 0.37 mmol/l. Need in insulin diminished by 10%.
Conclusion. Treatment results showed that administration of rosiglitazone in combination with NPH insulin has a good safety and tolerance profile in type 2 DM patients.
Material and methods. The trial included 43 patients with DM aged 44-75 on NPH insulin. The patients were divided into two groups. The study group received NPH insulin + a single morning dose of 4 mg/day rosiglitazone, the control group received NPH insulin only. The treatment lasted 24 weeks.
Results. 24-week therapy in the study group lowered HbA1c from 8.16 ± 0.23 to 6.82 ± 0.18% (p < 0.05), fasting glycemia - from 9.68 ± 0.48 to 6.4 ± 0.32 mmol/l, postprandial glycemia - from 12.3 ± 0.44 to 8.4 ± 0.56 mmol/l, HOMA-IR index - from 7.65 ± 1.12 to 4.26 ± 0.59. In group 2 HbA1c - from 7.84 ± 0.15 to 7.49 ± 0.17 (p < 0.05), from 9.21 ± 0.65 to 8.38 ± 0.50 mmol/l, 11.92 ± 0.53 to 9.97 ± 0.45 mmol/l, 6.77 ± 0.79 to 5.73 ± 0.63. The combined treatment produced positive changes in lipid metabolism: total cholesterol decreased from 6.37 ± 0.36 to 5.67 ± 0.32 mmol/l (p < 0.005), TG - from 2.46 ± 0.64 mmol/l to 1.82 ± 0.46 mmol/l (p < 0.005), LDLP - from 3.99 ± 0.40 to 3.58 ± 0.37 mmol/l. Need in insulin diminished by 10%.
Conclusion. Treatment results showed that administration of rosiglitazone in combination with NPH insulin has a good safety and tolerance profile in type 2 DM patients.
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References
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