Email this article Antihypertensive and organ-protective action of a 36-week monotherapy with telmisartan in hypertensive patients
- Authors: Petriy VV1, Sergushkina NG1, Brazhnik VA1, Makolkin VI1, Petry VV1, Sergushkina NG1, Brazhnik VA1, Makolkin VI1
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Affiliations:
- Issue: Vol 80, No 12 (2008)
- Pages: 13-16
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30240
- ID: 30240
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Abstract
Material and methods. The trial enrolled 33 patients with EH of stage II, blood pressure (BP) elevation of the first and second degree, with ultrasound-diagnosed left ventricular (LV) hypertrophy and/ or increased thickness of intima-media complex (IMC) of the muscular-elastic vessels. The patients received 40-80 mg/day telmisartan monotherapy for 36 weeks. Hypotensive efficacy of the drug was assessed at 24-hr BP monitoring, a protective effect - at echocardiography and ultrasound duplex scanning of the vessels.
Results. A 36-week telmisartan monotherapy significantly improved all the analysed parameters of 24-hr BP monitoring. LV myocardial mass reduced by 12.7%, index of this mass - by 12.9%. Overall thickness of intima-media of the muscular-elastic vessels (common carotid and femoral arteries) lowered by 11.9%.
Conclusion. Long-term telmisartan monotherapy improves parameters of 24-hr BP monitoring, protects the heart and the vessels against remodeling, promotes reduction of LV hypertrophy and intima-media thickness of muscular-elastic arteries.
About the authors
V V Petriy
N G Sergushkina
V A Brazhnik
V I Makolkin
V V Petry
N G Sergushkina
V A Brazhnik
V I Makolkin
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