Antihypertensive and organ-protective action of a 36-week monotherapy with telmisartan in hypertensive patients

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Abstract

Aim. To study hypotensive effectiveness and organ-protective properties of telmisartan in patients with essential hypertension (EH).
Material and methods. The trial enrolled 33 patients with EH of stage II, blood pressure (BP) elevation of the first and second degree, with ultrasound-diagnosed left ventricular (LV) hypertrophy and/ or increased thickness of intima-media complex (IMC) of the muscular-elastic vessels. The patients received 40-80 mg/day telmisartan monotherapy for 36 weeks. Hypotensive efficacy of the drug was assessed at 24-hr BP monitoring, a protective effect - at echocardiography and ultrasound duplex scanning of the vessels.
Results. A 36-week telmisartan monotherapy significantly improved all the analysed parameters of 24-hr BP monitoring. LV myocardial mass reduced by 12.7%, index of this mass - by 12.9%. Overall thickness of intima-media of the muscular-elastic vessels (common carotid and femoral arteries) lowered by 11.9%.
Conclusion. Long-term telmisartan monotherapy improves parameters of 24-hr BP monitoring, protects the heart and the vessels against remodeling, promotes reduction of LV hypertrophy and intima-media thickness of muscular-elastic arteries.

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Copyright (c) 2008 Petriy V.V., Sergushkina N.G., Brazhnik V.A., Makolkin V.I., Petry V.V., Sergushkina N.G., Brazhnik V.A., Makolkin V.I.

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