Impact of ahemodialysis session on cardiac function in patients withchronic renal failure


Aim. To determine the impact of hemodialysis (HD) session on cardiac function in patients with
chronic renal failure.
Material and methods. Thirty patients (17 male, 13 female, mean age 49 ± 11 years) on bicarbonate
HD were studied. M-mode echocardiography was performed and ejection fraction (ЕЕ) was estimated.
Transmitral flow was assessed by Doppler echocardiography. Peak velocity of early (E) and late (A)
filling, E/A ratio, isovolumic relaxation time (IVRT) and early deceleration time (DT) were estimated.
All the estimations were made one hour before and immediately after HD by one investigator. Flow
propagation velocity of early diastolic flow was assessed by color M-mode Doppler echocardiography.
Results. A significant decrease of the ejection fraction (delta EF) was observed only in patients with
intradialytic hypotension. Hemodialysis resulted in a decrease of early flow velocity from 99.2 ± 23.8
to 80.6 ± 26.0 cm/s (p = 0.0000) and E/A ratio from 1.23 + 0.57 to 0.98 ± 0.43 (p = 0.006). IVRT
and DT showed no significant difference. There was a significant positive correlation between the
amount of ultrafiltration and deltaE (r = 0.46; p = 0.01), there was no correlation between the
amount of ultrafiltration and delta Vp (r = -0.01;p = 0.9).
Conclusion. The results show that a hemodialysis session influences cardiac function in patients with
chronic renal failure. Early diastolic filling considerably decreased in correlation with ultrafiltration. A
significant decrease in an ejection fraction was detected only in patients with intradialytic hypotension.
Ultrafiltration had no impact on flow propagation velocity of early diastolic flow of the left ventricle assessed by color M-mode Doppler echocardiography.


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