Pharmacotherapy of acute tonsillopharyngitis in outpatient setting: results of a multicenter pharmacoepidemiological study


Aim. To analyse current practice of pharmacotherapy (PT) in outpatient treatment of acute tonsillopharyngitis (ATP) in different regions of Russia.
Material and methods. Case repords for 1333 outpatients (493 male and 840 female, age 16-76 years) with ATP from 7 cities of Russia have been studied. Each ATP case was documented on a special chart to contain the following information: demographic data, history of the disease, bacteriological findings, FT regimens, complications, treatment outcomes.
Results. FT of ATP was made primarily with antibiotics. Most frequent of them was ampicillin (about half the cases). Further antibiotics by frequency of use were: erythromycin, ciprofloxacin, doxicyclin, amoxicillin, midecamycin, ampicillin/oxacillin. Among other drugs, wide use was registered of antihistamine drugs, throat disease drugs, analgetic and antipiretic drugs, vitamins. Bacteriological examinations were conducted rarely.
Conclusion. The problems ofFTofATP patients consist in overuse of systemic antibiotics as a result of adequate differential diagnosis of this infection and choice of antibiotics without consideration of current recommendations on the treatment of streptococcal ATP.


  1. Gwaltney J. M., Bisno A. L. Pharyngitis. In: Mandell G. L., Bennett J. E., Dolin R. (eds.) Principles and practice of infectious diseases. 5th ed. Philadelohia: Churchill Livingstone; 2000. 656-662,
  2. Clements D. A. Pharyngitis, laryngitis, epiglottitis. In: Armstrong D., Cohen J. (eds.) Infectious diseases. London: Harcourt Publishers Ltd; 1999; vol. 1: 24.1-24.6.
  3. Bisno A. L. Acute pharyngitis. N. Engl. J. Med. 2001; 344: 205-211.
  4. Насонова В. А., Белов Б. С., Страчунский Л. С. и др. Антибактериальная терапия стрептококкового тонзиллита и фарингита. Клин, микробиол. и антимикроб, химиотер. 1999; 1: 78-82.
  5. Bisno A. L., Gerber M. A., Gwaltney J. M. et al. Practice guidelines for the diagnosis and management of group A streptococcal pharyngitis. Clin. Infect. Dis. - 2002; 35: 113-125.
  6. Gerber M. A. Diagnosis and treatment of group A streptococcal pharyngitis. Pediatr. Infect. Dis. 1998; 9: 42-49.
  7. Белов Б. С., Насонова В. А., Гришаева Т. П. Ревматологические аспекты стрептококкового тонзиллита и современные подходы к его антибактериальной терапии. КАХ 2000; 2: 52-56.
  8. Leblebicioglu H., Canbaz S., Peksen Y. et al. Physicians' antibiotic prescribing habits for upper respiratory tract infections in Turkey. J. Chemother. 2002; 14: 181-184.
  9. Butler С. С., Rollnick S., Pill R. et al. Understanding the culture of prescribing: qualitative study of general practitioners and patients perceptions of antibiotics for sore throats. Br. Med. J. 1998; 317: 637-642.
  10. Mandell G. L., Perty W. A. Jr. Penicillins, cephalosporines and other p-lactam antibiotics. In: Hardman J. G., Limbird L. E., Molinoff P. В., Ruddon R. W. (eds.) The pharmacological basis of therapeutics. 9th ed. New York: McGraw-Hill; 1996. 1073-1102.
  11. Brook I. The role of (5-lactamase producing bacteria and bacterial interference in streptococcal tonsillitis. Intern. J. Antimicrob. Agents 2001; 17: 439-442.
  12. Sivaja O. V., Kozlov R. S., Stratchounski L. S., PEHASus Project Group. Current state of antimicrobial resistance of S. pyogenes (GAS) in Russia: results of prospective multicenter study (PeGASus-1, phase "B"). In: Proceedings of the 1st FEMS Congress of European microbiologists. Amsterdam: Elsevier; 2003.
  13. Страчунский Л. С., Козлов С. Н. Макролиды в современной клинической практике. Смоленск: Русич; 1998.
  14. Mandell G. L., Bennett J. E., Dolin R. (eds.) Principles and practice of infectious diseases. 5th ed. Philadelphia: Churchill Livingstone; 2000.
  15. Hooper D.C., Rubinstein E. (eds.) Quinolone antimicrobial agents. 3rd ed. Washington; 2003.
  16. Лопатин А. С. Местные антимикробные препараты в лечении инфекций верхних дыхательных путей. КАХ 2000; 2: 71-74.
  17. Профилактика стрептококковой (группы А) инфекции. Санитарно-эпидемиологические правила СП 03. Зарегистрировано в Минюсте РФ 7 апр. 2003 г. № 4385.

Copyright (c) 2004 Kozlov S.N., Strachunsky L.S., Rachina S.A., Dmitrenok O.V., Ilyuschenko L.A., Kuzin V.В., Ortenberg E.A., Palyutin S.K., Sosonnaya N.A.

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