Ethnic differences in apolipoprotein В levels in hyperlipidemia in Russians and the Kirghiz

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Aim. To evaluate the levels of apolipoprotein В (apo-B) and coronary heart disease (CHD) risk factors in Russians and the Kirghiz with primary hyperlipemia (PHL).
Material and methods. Lipid spectrum of the blood (LDLP and HDLP cholesterol, total cholesterol, triglicerides), apo-B, CHD risk factors were studied in 60 Russian and 75 Kirghis patients with PHL aged 28 to 67years (mean age 50.0 + 7.59 years, 56females and 79 males). Results. In Russians a mean level of LDLP cholesterol and apo-B was significantly higher than in Kirghiz patients (3.95 + 1.29 mmol/l vs 3.51+1.17 mmol/l, p = 0.042; 173.3+ 57.3 mg/dl vs 145.5 + 49.3 mg/dl, p = 0.003, respectively). CHD in both ethnic groups occurred with similar rates. The multifactorial regression analysis shows that an apo-B concentration can serve an independent risk factor associated with CHD in the Kirghiz population (p = 0.25, p = 0.03) while in Russians living in Kirghizia this factor is a low content of HDLP cholesterol (p = -0.25, p = 0.05).


  1. Clark L. Т., Ferdinand К. С., Flack J. M. et al. Coronary heart disease in African Americans. Heart Dis. 2001; 3: 97-108.
  2. Howard B. V., Lee E. Т., Cowan L. D. et al. Coronary heart disease prevalence and its relation to risk factors in American Indians: the Strong Heart Study. Am. J. Epidemiol. 1995; 142: 254-268.
  3. Wei M., Mitchell В. D., Haffiter S. M., Stern M. P. Effects of cigarette smoking, diabetes, high cholesterol, and hypertension on all-cause mortality and cardiovascular disease mortality in Mexican Americans: the San Antonio Heart Study. Am. J. Epidemiol. 1996; 144: 1058-1065.
  4. Enas E. A., Yusuf S., Sharma S. Coronary artery disease in South Asians', second meeting of the International Working Group. Indian Heart J. 1998; 50: 105-113.
  5. Abbot R. D., Sharp D. S., Burchifiel С. М. et al. Cross-sectional and longitudinal changes in total and high density-lipoprotein cholesterol levels over 20-year period in elderly men: the Honolulu Heart Program. Ann. Epidemiol. 1997; 7: 417-424.
  6. Айтбаев К. А., Мейманалиев Т. С., Шлейфер Е. А. и др. Питание и распространенность ИБС и факторов ее риска среди мужчин 20-59 лет. Волр. питания 1988; 4: 28-32.
  7. Expert panel on detection, evaluation and treatment of high blood cholesterol in adults ATP HI. J. A. M. A. 2001; 285: 2486-2497.
  8. Reinhart R. A., Gani K., Arndt M. R. et al. Apolipoprotein A-I and В as predictors of angiographically defined coronary artery disease. Arch. Intern. Med. 1990; 150: 1629-1633.
  9. Levinson S. S., Wagner S. G. Measurement of apoliprotein Bcontaining lipoproteins for routine clinical laboratory use in cardiovascular disease. Arch. Pathol. Lab. Med. 1992; 116 (12): 1350-1354.
  10. al-Kateb H., Zarzzour W., Shameah M., Juoma M. Coronary risk factors of angiographically assessed patients from Syria. J. Cardiovasc. Risk 1998; 5 (1): 31-35.
  11. Lynch J., Marshall M. D., Wang W. X. et al. Apolipoprotein screening in Australian children: feasibility and the effect of age, sex, and ethnicity. Med. J. Aust. 1998; 68: 61-64.
  12. Fong P. C., Tarn S. C., Tai Y. T. et al. Serum lipid and apolipoprotein distributions in Hong Kong. Chin. J. Epidemiol. Commun. Hlth 1994; 48 (4): 355-359.
  13. Lamarche В., Moorjani S., Lupien P. J. et al. Apolipoprotein A-I and В levels and risk of ischemic heart disease during a five-year follow-up of men in the Quebec Cardiovascular Study. Circulation 1996; 94: 273-278.
  14. Джолдасбекова А. У., Рысмендиев А. Ж., Байтасова Н. Б., Шуратова С. Г. Состояние перекисного окисления липидов и антиоксидантной систем у больных ИБС уйгурской национальности. Здравоохр. Казахстана 1997; 1: 14-25.

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