Preclinical diagnosis of renal damage in essential hypertension


Aim. To study renal functional reserve and 24-h beta2-microglobulinuria (B2-MGU)in patients with different stages of essential hypertension (EH) and to evaluate acceptability of these parameters as early markers of preclinical renal impairment in EH.
Methods. We examined 150 patients (mean age 42.1 ± 3.4 years) with EH without overt clinical manifestations of hypertensive nephropathy. Renal functional reserve (RFR) was determined with the use of acute oral protein loading and was defined as an increase in endogenic creatinine clearance in percent. B2-MGU was evaluated by radioimmunoassay (RIO-BETA-2-M1CRO kit). Radioimmunoassay detection of microalbuminuria (MA U) was performed with the use of the standard kit Albumin-RIA.
Results. RFR appeared to be significantly lower in patients with EH compared to the control group, and its level significantly decreased with aggravation of EH. Both B2-MGU and MAU were significantly higher in patients with EH and significantly increased with aggravation of EH. Conclusion. We suggest that, apart from MAU, RFR abnormalities and excessive B2-MGU should be used as markers of preclinical renal impairment in EH.

About the authors

Yu I Grinstein

V V Shabalin


  1. Valderrabano F., Gomez-Campdera F., Jones E. H. Hypertension as cause of end-stage renal disease: lessons from international registries. Kidney Int. 1998; 68 (suppl.) 60-66.
  2. Caetano E. P., Zatz R., Praxedes J. N. The clinical diagnosis of hypertensive nephrosclerosis - how reliable is it? Nephrol. Dial. Transplant. 1999; 14: 288-290.
  3. Mogensen С. Е., Chachati A., Christensen С. К. et al. Microalbuminuria: An early marker of renal involvement in diabetes. Uremia Invest. 1986; 9: 85-95.
  4. Мухин Н. А., Дедов И. И., Шестакова М. В. и др. Функциональные почечные резервы у больных сахарным диабетом. Тер. арх. 1990; 2: 107-110.
  5. de Santo N. G., Cirillo M., Anastasio P. et al. Renal response to an acute oral protein load in healthy humans and in patients with renal disease or liver cirrhosis. Semin. Nephrol. 1995; 15: 433-448.
  6. Brenner В. М. Hemodynamically mediated glomerular injury and the progressive nature of kidney disease. Kidney Int. 1983; 23 (4): 647-655.
  7. Gabbai F. B. Renal reserve in patients with high blood pressure. Semin. Nephrol. 1995; 15 (5): 482-487.
  8. Zitta S., Stoschitzky K., Zweiker R. et al. Dynamic renal function testing by compartmental analysis: assessment of renal functional reserve in essential hypertension. Nephrol. Dial. Transplant. 2000; 15 (8): 1162-1169.
  9. Шулутко Б. И., Перов Ю. Л. Артериальная гипертензия. СПб: ГИПП "Искусство России"; 1993.
  10. Harrap S. В., dimming A. D., Davies D. L. et al. Glomerular hyperfiltration, high renin, and low-extracellular volume in high blood pressure. Hypertension 2000; 35 (4): 952-957.
  11. Евсиков E. M., Люсов В. А., Байкова О. А., Шапарова Ж. Б. Природа эссенциальной гипертензии. Рос. кардиол. журн. 2002; 5:4-12.
  12. Ruilope L. М., Rodlcio J. L. The kidney in arterial hypertension. Nephrol. Dial. Transplant. 2001; 16 (suppl. 1): 50-53.
  13. Pontremoli R. Microalbuminuria in essential hypertension: Its relation to cardiovascular risk factors. Nephrol. Dial. Transplant. 1996; 11: 2113-2134.
  14. Martinez M. A., Moreno A., Aguirre A. et al. Frequency and determinants of microalbuminuria in mild hypertension: a primary-care-based study. J. Hypertens. 2001; 19 (2): 319-326.
  15. Bianchi S., Bigazzi R., Campese V. M. Microalbuminuria in essential hypertension: significance, pathophysiology, and therapeutical implications. Am. J. Kidney Dis. 1999; 34 (6): 973- 995.
  16. Bigazzi R., Bianchi S., Baldari D. et al. Microalbuminuria predicts cardiovascular events and renal insufficiency in patients with essential hypertension. J. Hypertens. 1998; 16 (9): 1325- 1333.
  17. Mimran A., Ribstein J., Du Cailar G. Microalbuminuria in essential hypertension. Curr. Opin. Nephrol. Hypertens. 1999; 8 (3): 359-363.
  18. Abbate M., Benigni A., Bertani T. et al. Nephrotoxicity of increased glomerular protein traffic. Nephrol. Dial. Transplant. 1999; 14 (2): 304-312.
  19. Iglesias J., Levine J. S. Albuminuria and renal injury - beware of proteins bearing gifts. Nephrol. Dial. Transplant. 2001; 16 (1): 215-218.



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